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Chemical Structure| 10237-77-1 Chemical Structure| 10237-77-1
Chemical Structure| 10237-77-1

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3-Hydroxyvaleric acid is a five-carbon ketone body that replenishes tricarboxylic acid cycle intermediates through anaplerosis, playing a role in metabolic regulation and energy balance.

Synonyms: 3-Hydroxyvaleric acid

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Product Citations

Product Citations

Qingyun Dan, Yan Chiu, Namil Lee, Jose Henrique Pereira, Xixi Zhao, Chunjun Zhan, Yiou Rong, Yan Chen, Seokjung Cheong, Chenyi Li, Jennifer W. Gin, Andria Rodrigues, Tyler W. H. Backman, Edward E. K. Baidoo, Christopher J. Petzold, Paul D. Adams, Jay D. Keasling ;

Abstract: Medium- and branched-chain diols and amino alcohols are important industrial solvents, polymer building blocks, cosmetics and pharmaceutical ingredients, yet biosynthetically challenging to produce. Here, we present a novel approach utilising a modular polyketide synthase (PKS) platform for the efficient production of these compounds. This platform takes advantage of a versatile loading module from the rimocidin PKS and NADPH-dependent terminal thioreductases (TRs), previously untapped in engineered PKSs. Reduction of the terminal aldehyde with specific alcohol dehydrogenases enables production of diols, oxidation enables production of hydroxy acids, and transamination with specific transaminases enables production of various amino alcohols. Furthermore, replacement of the malonyl-coenzyme A (CoA)–specific acyltransferase (AT) in the extension module with methyl- or ethylmalonylCoA–specific ATs enables production of branched-chain diols and amino alcohols. In total, we demonstrated production of nine 1,3-diols (including the difficult-to-produce insect repellent and cosmetic ingredient 2-ethyl-1,3-hexanediol), six amino alcohols, and two carboxylic acids using our PKS platform in Streptomyces albus. Finally, tuning production of the PKS acyl-CoA substrates enabled production of high titers of specific diols and amino alcohols (1 g/L diol titer in shake flasks), demonstrating high tunability and efficiency of the platform.

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Product Details of 3-Hydroxyvaleric acid

CAS No. :10237-77-1
Formula : C5H10O3
M.W : 118.13
SMILES Code : CCC(O)CC(O)=O
Synonyms :
3-Hydroxyvaleric acid
MDL No. :MFCD07778468
InChI Key :REKYPYSUBKSCAT-UHFFFAOYSA-N
Pubchem ID :107802

Safety of 3-Hydroxyvaleric acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338
 

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