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Chemical Structure| 30082-45-2 Chemical Structure| 30082-45-2

Structure of 30082-45-2

Chemical Structure| 30082-45-2

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Product Details of [ 30082-45-2 ]

CAS No. :30082-45-2
Formula : C14H11ClO3
M.W : 262.69
SMILES Code : O=C(O)C1=CC=CC(COC2=CC=CC=C2Cl)=C1
MDL No. :MFCD00625985

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Application In Synthesis of [ 30082-45-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30082-45-2 ]

[ 30082-45-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 28466-26-4 ]
  • [ 30082-45-2 ]
  • [ 1018445-75-4 ]
YieldReaction ConditionsOperation in experiment
7.8% Example 150 3-[(2-chlorophenoxy)methyl]-N-1H-pyrazol-4-ylbenzamide 3-[(2-Chlorophenoxy)methyl]benzoic acid was suspended in tetrahydrofuran (50 mL), and oxalyl chloride (1.03 mL) and N,N-dimethylformamide (catalytic amount) were added. After stirring at room temperature for 30 min, the mixture was added dropwise to a suspension of <strong>[28466-26-4]1H-pyrazol-4-amine</strong> (1.0 g) in N,N-dimethylacetamide (50 mL). After stirring at room temperature for 5 hr, ethyl acetate was added, and the mixture was washed 3 times with saturated aqueous sodium hydrogen carbonate solution. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography and recrystallized from ethyl acetate/hexane to give the object product (280 mg, 7.8%). 1H NMR (300 MHz, DMSO-d6) delta ppm 5.29 (s, 2H) 6.93-7.02 (m, 1H) 7.22-7.35 (m, 2H) 7.46 (dd, J=1.51, 7.91 Hz, 1H) 7.56 (t, J=7.72 Hz, 1H) 7.63-7.70 (m, 1H) 7.85 (brs, 2H) 7.89-7.95 (m, 1H) 8.02-8.06 (m, 1H) 10.47 (s, 1H) 12.63 (brs, 1H)
 

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