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Chemical Structure| 3017-32-1 Chemical Structure| 3017-32-1

Structure of H-Lys(Boc)-OMe
CAS No.: 3017-32-1

Chemical Structure| 3017-32-1

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Product Details of [ 3017-32-1 ]

CAS No. :3017-32-1
Formula : C12H24N2O4
M.W : 260.33
SMILES Code : O=C(OC)[C@@H](N)CCCCNC(OC(C)(C)C)=O
MDL No. :MFCD27578198
InChI Key :JZJOGMHGKPNPTO-VIFPVBQESA-N
Pubchem ID :7018776

Safety of [ 3017-32-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 3017-32-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3017-32-1 ]

[ 3017-32-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3017-32-1 ]
  • [ 525-03-1 ]
  • [ 3218-02-8 ]
  • [ 294181-72-9 ]
  • [ 762241-25-8 ]
YieldReaction ConditionsOperation in experiment
It is disclosed herein that the display of side chains identified as activein galanin or those of the nonpeptide galanin receptor agonist galnon on arigid platform creates a compound capable of recognition by the receptorGalR1. Mixtures of 3 to 4 amines were coupled to the triacid platform (D. Mink,et al., Tetrahedron Lett, (1998) 39, 5709-5712; G. Haberhauer, et al.,Tetrahedron Lett, (2000) 41, 5013-5016; and L. Somogyi, et al., Tetrahedron,(2001) 57, 1699-1708) and obtained small combinatorial libraries. Activemixtures were obtained (after deblocking with trifluoroacetic acid) from theamines shown: cyclohexylmethyl amine, 2; fluorenyl amine 3 ande-t-BOC-/-lysine methyl ester 4. This mixture (11 compounds) was fractionatedby HPLC and the most active compound (structure 5, Galmic, or itscyclodiastereomer) was identified by mass spectrometry. The individualmolecule was prepared by total synthesis which will be described elsewhere. Physical Characterization of Galmic:1H NMR-300 MHz (CDCIs): 9.01 (s, NH); 8.94 (s, NH); 8.89 (s, NH); 7.97 (sbroad, 3H); 7.65 (d, J=7.5 Hz, 2H); 7.55 (d, J=7.2 Hz, 1H); 7.42-7.19 (m, 5H);6.87 (pseudo t, J=5.4 Hz, 1H); 6.15 (d, J=8.4 Hz, 1H); 4.55 (m broad, 1H); 3.61(s, 3H); 3.38 (s broad, 1H); 3.12 (m, 1H); 2.90 (m, 3H); 2.70 (s, 3H); 2.65 (s,6H); 2.19 (s, 3H); 2.09 (s, 3H); 2.04 (s, 3H); 2.00-1.28 (m, 14H); 1.20-1.04 (m,3H); 0.92-0.76 (m, 2H).13C NMR-75 (CDCIs): 171.61; 168.81; 167.39; 160.44;160.41; 160.11; 159.97; 159.17; 156.09; 156.03; 155.91; 143.62; 143.39;140.50; 140.43; 128.67 (CH); 128.58 (CH); 127.85 (CH); 127.65 (CH); 124.97(CH); 124.72 (CH); 119.87 (CH); 60.68; 60.45; 59.90; 55.34 (CH); 52.46 (CHs);52.16 (CH); 46.27 (CHa); 39.55 (CHa); 37.74 (CH); 30.63 (CHa); 26.43 (CHa);26.23 (CHa); 25.80 (CHa); 21.69 (CHs); 21.50 (CHs); 21.44 (CHs); 11.89 (3CHs). MALDI-FTMS [M+H]+: expected: 989.4510; observed: 989.4508.
  • 2
  • [ 24424-99-5 ]
  • [ 3017-32-1 ]
  • [ 2483-48-9 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; at 20℃; for 1h; Step E1-1: Methyl N2,N6-bis(tert-butoxycarbonyl)-L-lysinate. To a solution of epsilon-Boc Lysine methyl ester 1 (35.9g, 121 mmol) suspended in the CH2CI2 (250 mL) and stirred at room temperature, was added Boc2θ, 99% (28.1 mL, 121 mmol) followed by careful addition of triethylamine, 99.5% (20.23 mL, 145 mmol). The solids dissolved and gentle gas evolotuion was noted. After 1 hr the reaction mixture was clear pale yellow with no noticable gas evoluiton. An aliquot was concentrated under N2- The reaction mixture was allowed to sit overnight at room temperature. Transfer to a sep funnel and wash with water (2 x 25OmL), NaHCO3 (50 mL 50% saturated), and brine. Dry over MgSO4 , filter and concentrate to an off white solid, wt 42 g. MS: M+Na = 383.
  • 3
  • [ 3017-32-1 ]
  • [ 98045-03-5 ]
  • C22H39N3O9 [ No CAS ]
 

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