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Chemical Structure| 30216-57-0 Chemical Structure| 30216-57-0

Structure of 30216-57-0

Chemical Structure| 30216-57-0

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Product Details of [ 30216-57-0 ]

CAS No. :30216-57-0
Formula : C4H2ClNOS
M.W : 147.58
SMILES Code : O=C(Cl)C1=NC=CS1
MDL No. :MFCD06658970
InChI Key :HKZCFGQSWLWNQA-UHFFFAOYSA-N
Pubchem ID :2795211

Safety of [ 30216-57-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 30216-57-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30216-57-0 ]

[ 30216-57-0 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 30216-57-0 ]
  • [ 2734-70-5 ]
  • N-(2,6-dimethoxyphenyl)thiazole-2-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; for 19h;Cooling with ice; To an ice-cooled solution of <strong>[2734-70-5]2,6-dimethoxyaniline</strong> (Amfinecom Inc., 1.2 g, 7.8 mmol) in DCM (20 mL) was added N,N-diisopropylethylamine (2.73 mL, 15.7 mmol) via syringe followed by a solution of 1,3-thiazole-2-carbonyl chloride (Maybridge, 1.16 g, 7.9 mmol) in DCM (27 mL) slowly via cannula. The resulting brown solution was allowed to warm to RTand stirred for 19 h. The reaction was then partitioned between water (80 mL) and DCM (2X). The combined organic layers were washed with brine (2X), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (eluent: 10-100% EtOAc in hexanes) to provide 396.1 (1.30 g, 63% yield) as a light yellow solid. LCMS-ESI (pos.) m/z: 265.2 (M+H)+.
 

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