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Chemical Structure| 302964-11-0 Chemical Structure| 302964-11-0

Structure of 302964-11-0

Chemical Structure| 302964-11-0

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Product Details of [ 302964-11-0 ]

CAS No. :302964-11-0
Formula : C11H8Cl2N2OS
M.W : 287.17
SMILES Code : O=C(C1=CN=C(Cl)S1)NC2=C(C)C=CC=C2Cl
MDL No. :MFCD19980741

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Application In Synthesis of [ 302964-11-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 302964-11-0 ]

[ 302964-11-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42237-85-4 ]
  • [ 302964-11-0 ]
  • 3-bromo-5-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)amino)benzoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With camphor-10-sulfonic acid; In toluene; tert-butyl alcohol; at 120℃; for 3.5h;Inert atmosphere; Microwave irradiation; 2-Chloro-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide (1.33 g, 4.63 mmol) and (+)-camphor-10-sulfonic acid (CSA) (1.08 g, 4.63 mmol, dried with toluene) were dissolved in t-butanol (10 ml) and put under argon atmosphere. 3-Amino-5- bromobenzoic acid (1.00 g, 4.63 mmol) was added slowly. The mixture wasirradiated with a microwave synthesis reactor at 120 C for 3.5 h under constant stirring. It was diluted with ethyl acetate (EA) (10 ml), washed with saturated aqueous NH4CI (20 ml), washed with saturated aqueous NaCI (20 ml) and extracted with EA (3 * 20 ml). The organic layer was dried with MgSO4 and the solvent was evaporated. For purification, the crude was resolved in EA (5 ml),cooled down and crystallized by adding chilled petrol ether (PE). After filtration, the product 3-bromo-5-((5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2- yl)amino)benzoic acid (1.98 g, 92 %) was yielded as a brown solid.
 

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