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Chemical Structure| 30425-47-9 Chemical Structure| 30425-47-9

Structure of 30425-47-9

Chemical Structure| 30425-47-9

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Product Details of [ 30425-47-9 ]

CAS No. :30425-47-9
Formula : C11H13NO2
M.W : 191.23
SMILES Code : O=C1N(C2=CC=C(OC)C=C2)CCC1
MDL No. :MFCD00138488

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Application In Synthesis of [ 30425-47-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30425-47-9 ]

[ 30425-47-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 117324-58-0 ]
  • [ 30425-47-9 ]
  • methyl 2-((1-(4-methoxyphenyl)pyrrolidin-2-ylidene)amino)-5-(trifluoromethyI)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
53% A solution of 1 -(4-methoxyphenyl)pyrrolidin-2-one (2.00 g, 10.5 mmol) in methylene chloride (20 ml_) was treated with phosphorous oxychloride (1.46 ml_, 15.7 mmol) and stirred under a nitrogen atmosphere at ambient temperature for 7 h. The mixture was treated with a solution of <strong>[117324-58-0]methyl 2-amino-5-(trifluoromethyl)benzoate</strong> (3.21 g, 14.6 mmol) in methylene chloride (20 ml_) and heated at 45 C for 2 d. After this time, the reaction mixture was allowed to cool to ambient temperature, quenched with saturated aqueous sodium bicarbonate (40 ml_), and extracted with ethyl acetate. The organics were dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified by column chromatography (silica gel, 12-100% ethyl acetate/heptane) to provide methyl 2-((1-(4-methoxyphenyl)pyrrolidin-2-ylidene)amino)-5-(trifluoromethyl)benzoate (2.19 g, 53%) as a clear gum: 1 H NMR (500 MHz, CDCIs) d 8.10 (s, 1H), 7.63 (d, J = 8.5 Hz, 2H), 7.56 (dd, J = 8.5, 1.5 Hz, 1H), 6.90 (d, J = 8.5 Hz, 3H), 3.88-3.85 (m, 5H), 3.79 (s, 3H), 2.47 (t, J = 7.5 Hz, 2H), 2.1 1-2.05 (m, 2H).
 

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