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Chemical Structure| 3052-50-4 Chemical Structure| 3052-50-4

Structure of 3052-50-4

Chemical Structure| 3052-50-4

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Product Details of [ 3052-50-4 ]

CAS No. :3052-50-4
Formula : C5H6O4
M.W : 130.09
SMILES Code : O=C(OC)/C=C\C(O)=O
MDL No. :MFCD00045905
InChI Key :NKHAVTQWNUWKEO-IHWYPQMZSA-N
Pubchem ID :5354456

Safety of [ 3052-50-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Application In Synthesis of [ 3052-50-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3052-50-4 ]

[ 3052-50-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2734-70-5 ]
  • [ 3052-50-4 ]
  • methyl (2Z)-4-[(2,6-dimethoxyphenyl)amino]-4-oxobut-2-enoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
26% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 1h; To a solution of 2 , 6-dimethoxyaniline (2.00 g, 13.1 mmol) and maleic acid monomethyl ester (1.87 g, 14.4 mmol) in dichloromethane (39 mL), l-ethyl-3- ( 3- dimethylaminopropyl ) carbodiimide hydrochloride (3.13 g, 16.3 mmol) and 4-dimethylaminopyridine (16 mg, 0.1306 mmol) were added, and the mixture was stirred at room temperature for 1 hour. The reaction solution was diluted with dichloromethane, washed with a 1 N aqueous hydrochloric acid solution, a saturated aqueous solution of sodium bicarbonate, and saturated saline, and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography [elution solvent: n-hexane/ethyl acetate = 40/60 - 10/90 (V/V) ] to obtain the title compound (897 mg, 3.38 mmol, 26%) as a white solid.1H-NMR (400 MHz, CDC13) δ (ppm) : 3.81 (3H, br s), 3.84 (6H, s), 6.10-6.31 (1H, br m) , 6.37-6.53 (1H, br m) , 6.60 (2H, d, J = 8.5 Hz), 7.19 (1H, t, J = 8.5 Hz), 9.43 (1H, br s) . MS (APCI) : m/z 266 [M+H]+.
 

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