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Chemical Structure| 307308-62-9 Chemical Structure| 307308-62-9

Structure of 307308-62-9

Chemical Structure| 307308-62-9

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Product Details of [ 307308-62-9 ]

CAS No. :307308-62-9
Formula : C12H10FNO
M.W : 203.21
SMILES Code : NC1=CC=C(OC2=CC=CC(F)=C2)C=C1
MDL No. :MFCD02663349
Boiling Point : No data available
InChI Key :OHACTALIXWVZFF-UHFFFAOYSA-N
Pubchem ID :15453825

Safety of [ 307308-62-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 307308-62-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 307308-62-9 ]

[ 307308-62-9 ] Synthesis Path-Downstream   1~12

  • 2
  • 2,5-bis-[4-(5-oxo-2-trifluoromethyl-4,5-dihydro-oxazol-4-yl)-phenoxymethyl]-benzoyl chloride [ No CAS ]
  • [ 307308-62-9 ]
  • [ 1244974-95-5 ]
  • 4
  • [ 583878-42-6 ]
  • [ 307308-62-9 ]
  • [ 1457983-65-1 ]
YieldReaction ConditionsOperation in experiment
With acetic acid; at 100.0℃; for 2.0h; A 40 mL reaction vial was charged with a (1.85 g, 7.52 mmol), and <strong>[307308-62-9]4-(3-fluorophenoxy)aniline</strong> (1.65 g, 8.10 mmol) in 10 mL acetic acid. After being stirred at 100 C for 2 hours, volatiles were removed under reduced pressure yielding the brown residue. The residue was dissolved in methylene chloride and then washed with saturated aqueous sodium bicarbonate solution. The separated organic layer was dried over sodium sulfate and then concentrated to give (239c) as a brown residue. The resulting crude product was used to next step without purification.
  • 5
  • [ 307308-62-9 ]
  • [ 1457983-62-8 ]
  • 6
  • [ 307308-62-9 ]
  • [ 1457983-63-9 ]
  • 7
  • [ 307308-62-9 ]
  • N-(4-chloro-7-methoxy-6-quinazolinyl)propanamide [ No CAS ]
  • N-{4-[4-(3-fluorophenoxy)anilino]-7-methoxy-6-quinazolinyl}-propanamide [ No CAS ]
  • 8
  • [ 307308-62-9 ]
  • [ 79-04-9 ]
  • 2-chloro-N-(4-(3-fluorophenoxy)phenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% With triethylamine; In dichloromethane; To a solution of 4-(3- fluorophenoxy)aniline (AK Scientific, 63 mg, 0.31 mmol) in DCM 2-chloroacetyl chloride (Sigma, 42 mg, 0.37 mmol) and triethylamine (Sigma, 38 mg, 0.37 mmol) were added and the reaction stirred overnight. Upon reaction completion the crude was purified by silica gel chromatography (10-40% EtOAc/hexanes) to yield 53 mg (61%).1H NMR (400 MHz, CDCl3): d 8.24 (s, 1H), 7.55 (dq, J = 10.0, 3.5, 2.4 Hz, 2H), 7.33- 7.23 (m, 1H), 7.05 (dq, J = 10.1, 3.5, 2.6 Hz, 2H), 6.85- 6.74 (m, 2H), 6.69 (dq, J = 10.2, 2.3 Hz, 1H), 4.21 (s, 2H).13C NMR (151 MHz, CDCl3): d 164.29, 163.75, 162.66, 158.85, 158.78, 153.31, 132.67, 130.51, 130.45, 121.95, 120.13, 113.71, 113.69, 109.98, 109.84, 105.92, 105.75, 77.19, 76.97, 76.76, 42.79. HRMS: (-ESI): calcd. for: C14H10O2NFCl = 278.0390, found: 278.0389.
  • 9
  • [ 307308-62-9 ]
  • 1-(4-(3-fluorophenoxy)phenyl)-3-methyldihydropyrimidine-2,4(1H,3H)-dione [ No CAS ]
  • 10
  • [ 307308-62-9 ]
  • [ 57-13-6 ]
  • [ 79-10-7 ]
  • 1-(4-(3-fluorophenoxy)phenyl)dihydropyrimidine-2,4(1H,3H)-dione [ No CAS ]
  • 11
  • [ 372-20-3 ]
  • [ 307308-62-9 ]
  • 12
  • [ 350-46-9 ]
  • [ 307308-62-9 ]
 

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