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Chemical Structure| 31108-35-7 Chemical Structure| 31108-35-7

Structure of 31108-35-7

Chemical Structure| 31108-35-7

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Product Details of [ 31108-35-7 ]

CAS No. :31108-35-7
Formula : C8H12O4
M.W : 172.18
SMILES Code : CC(C(C(OC(C)(C)C)=O)=O)=O
MDL No. :MFCD03093346

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Application In Synthesis of [ 31108-35-7 ]

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  • Downstream synthetic route of [ 31108-35-7 ]

[ 31108-35-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 31108-35-7 ]
  • [ 67808-64-4 ]
  • [ 656227-58-6 ]
YieldReaction ConditionsOperation in experiment
With ammonium acetate; In acetonitrile; at 150℃; for 0.0833333h; A mixture of <strong>[67808-64-4]5-formyl-thiophene-2-carboxylic acid methyl ester</strong> [3.37g, 19.8mmol, Reference Example 37 [(A)],] 2,3-dioxo-butyric acid tert-butyl ester (3.4g, 19. [8MMOL),] ammonium acetate (15.25g, [198MMOL)] and acetonitrile [(38ML)] was subjected to microwave irradiation, heating to [150C] for 5 minutes. The reaction mixture was concentrated and the residue was partitioned between 2M sodium carbonate solution and ethyl acetate. The organic layer was separated, dried [(MGS04)] and concentrated to give an orange residue, which was subjected to flash column chromatography on silica using a mixture of pentane and ethyl acetate (gradient, 4: 1 to 1 : [1,] v/v) as eluent, to provide 2-(5-methoxycarbonyl- [THIOPHEN-2-YL)-5-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC] acid tert-butyl ester [(1.] [OG)] as a yellow powder.
 

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