Alternatived Products of [ 315-12-8 ]
Product Details of [ 315-12-8 ]
CAS No. : | 315-12-8 |
MDL No. : | MFCD03413407 |
Formula : |
C8H8FNO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | KDPQDERPJHLWGF-UHFFFAOYSA-N |
M.W : |
169.15
|
Pubchem ID : | 12651353 |
Synonyms : |
|
Application In Synthesis of [ 315-12-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 315-12-8 ]
- Downstream synthetic route of [ 315-12-8 ]
- 1
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[ 461-97-2 ]
-
[ 315-12-8 ]
-
[ 315-13-9 ]
- 2
-
[ 461-97-2 ]
-
[ 315-12-8 ]
Yield | Reaction Conditions | Operation in experiment |
83% |
With nitric acid; at -15 - 20℃; for 4h; |
1 (6 g, 48.3 mmol, 1 eq) was cooled to -10 ° C and nitric acid (9 g, 143.78 mmol, 3 eq) was added drop wise for 20 min. The mixture was stirred at -15 DEG C for 1 hour, then carefully brought to room temperature and kept stirring for 3 hours. The mixture was poured into ice to give a yellow precipitate, which was filtered and then the filter cake was dissolved in DCM. The organic phase was washed with brine, dried over Na2SO4 and concentrated to give the desired product 2 as a white powder (6.8 g, 83percent yield). |
- 3
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[ 315-12-8 ]
-
[ 2338-56-9 ]
- 4
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[ 315-12-8 ]
-
[ 14659-58-6 ]
- 5
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[ 315-12-8 ]
-
[ 14659-61-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: H2 / Pd-C
2: (i) NaNO2, aq. HCl, (ii) /BRN= 4652394/ |
|
- 6
-
[ 315-12-8 ]
-
[ 14659-60-0 ]
- 7
-
[ 315-12-8 ]
-
[ 16633-50-4 ]
- 8
-
[ 6418-38-8 ]
-
[ 315-12-8 ]
-
5-(2,3-difluoro-phenoxy)-1,3-dimethyl-2-nitro-benzene
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
79% |
With caesium carbonate; In N,N-dimethyl-formamide; at 120℃; for 3h; |
A mixture of 2,6-dimethyl-4-fluoro-1-nitro-benzene (2.49 g, 14.7 mmol), <strong>[6418-38-8]2,3-difluorophenol</strong> (1.91 g, 14.7 mmol) and Cs2CO3 (7.18 g, 22 mmol) in DMF (30 mL) was heated at 120 C for 3h. EtOAc was added and the mixture was washed with water and brine. The organic layer was dried, filtered, and evaporated. The residue was purified by chromatography (silica gel, 0-10% EtOAc/hexanes) to give 5- (2,3-difluoro-phenoxy)- 1 ,3-dimethyl-2-nitro-benzene (2.90 g, 79%) as a light yellow solid. MS calcd. for C14H12F2N03 [(M+H)?i 280, obsd. 279.8. |
- 9
-
[ 32860-17-6 ]
-
[ 315-12-8 ]
-
1-(3,5-dimethyl-4-nitrophenyl)4-(3-trifluoromethylphenyl)piperidine
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 12h; |
General procedure: A mixture of M-6 (252 mg, 1.41 mmol), 5-fluoro-1,3-dimethyl-2-nitrobenzene (238 mg, 1.41 mmol) and K2CO3 (427 mg, 3.09 mmol) in DMF(15 mL) was stirred at 100 for 12 h. Upon completion, the reaction solution was quenched with H2O (40 mL), extracted with ethyl acetate (3 × 40 mL). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography (10:1 petroleum ether: ethyl acetate eluent) to yield compound M-7 (397 mg, 86% yield). MS: 329.1[M+H]+. |
- 10
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[ 315-12-8 ]
-
[ 99329-53-0 ]
-
C19H21ClN2O2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 12h; |
General procedure: A mixture of M-6 (252 mg, 1.41 mmol), 5-fluoro-1,3-dimethyl-2-nitrobenzene (238 mg, 1.41 mmol) and K2CO3 (427 mg, 3.09 mmol) in DMF(15 mL) was stirred at 100 for 12 h. Upon completion, the reaction solution was quenched with H2O (40 mL), extracted with ethyl acetate (3 × 40 mL). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography (10:1 petroleum ether: ethyl acetate eluent) to yield compound M-7 (397 mg, 86% yield). MS: 329.1[M+H]+. |
- 11
-
[ 26905-02-2 ]
-
[ 315-12-8 ]
-
C19H21ClN2O2
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate; In N,N-dimethyl-formamide; at 100℃; for 12h; |
General procedure: A mixture of M-6 (252 mg, 1.41 mmol), 5-fluoro-1,3-dimethyl-2-nitrobenzene (238 mg, 1.41 mmol) and K2CO3 (427 mg, 3.09 mmol) in DMF(15 mL) was stirred at 100 for 12 h. Upon completion, the reaction solution was quenched with H2O (40 mL), extracted with ethyl acetate (3 × 40 mL). The combined organic layers were dried over sodium sulfate, concentrated in vacuo and purified by flash chromatography (10:1 petroleum ether: ethyl acetate eluent) to yield compound M-7 (397 mg, 86% yield). MS: 329.1[M+H]+. |