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Chemical Structure| 31785-15-6 Chemical Structure| 31785-15-6

Structure of 31785-15-6

Chemical Structure| 31785-15-6

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Product Details of [ 31785-15-6 ]

CAS No. :31785-15-6
Formula : C4H3N3S
M.W : 125.15
SMILES Code : N#CC1=C(N)SC=N1
MDL No. :MFCD19205888
InChI Key :ZCZQTYANSLFOOT-UHFFFAOYSA-N
Pubchem ID :22736805

Safety of [ 31785-15-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 31785-15-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31785-15-6 ]

[ 31785-15-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 402948-37-2 ]
  • [ 31785-15-6 ]
  • C18H19N7OS [ No CAS ]
YieldReaction ConditionsOperation in experiment
5.3% With lithium diisopropyl amide; In tetrahydrofuran; at 40℃;Inert atmosphere; Ethyl 2-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)acetate (150.0 mg, 0.495 mmol, 1.0 eq)And 5-aminothiazole-4-carbonitrile (62.1 mg, 0.495 mmol, 1.0 eq) was dissolved in tetrahydrofuran (4.5 mL).Stir at 40 C for 10 min under nitrogen protection.Lithium diisopropylamide (1.7 mL, 3.465 mmol, 7.0 eq) was slowly added.Stir at 40 C overnight.The reaction was quenched by EtOAc (EtOAc) (EtOAc)The crude product was subjected to silica gel column chromatography (DCM: MeOH=30:1 - 5:1)Purified red solid 7-amino-6-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)thiazolo[5,4-b]pyridine- 5(4H)-ketone(10.0 mg, yield: 5.3%).
 

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