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Chemical Structure| 31821-78-0 Chemical Structure| 31821-78-0

Structure of 31821-78-0

Chemical Structure| 31821-78-0

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Product Details of [ 31821-78-0 ]

CAS No. :31821-78-0
Formula : C11H14N4O3S
M.W : 282.32
SMILES Code : SC1=NN=C(C2=CC(OC)=C(OC)C(OC)=C2)N1N
MDL No. :MFCD02729432

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Application In Synthesis of [ 31821-78-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31821-78-0 ]

[ 31821-78-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 17641-08-6 ]
  • [ 31821-78-0 ]
  • C20H23N5O5S [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% With potassium carbonate; In ethanol;Reflux; General procedure: A mixture of the key intermediate 13 (1.0 mmol), diverse 2-chloro-N-sbustituted acetamidederivatives 15 (1.0 mmol) and potassium carbonate (K2CO3) (0.15 g, 1.1 mmol) in 5.0 mL ofanhydrous ethanol was stirred and refluxed for 2.0-2.5 h. After the reaction was complete accordingto the TLC detection, the precipitate was filtered off and solvent was removed under reducedpressure and the residue was purified by column chromatography to give the target compounds inyields of 57-78%.
  • 2
  • [ 17641-08-6 ]
  • [ 31821-78-0 ]
  • N-(3-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-6-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
66% With trichlorophosphate;Reflux; General procedure: 4-amino-3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione 8 was synthesized according to the literature [50] and intermediates 10 and 12 were prepared according to our previously reported approach [33,51]. Method A. To a solution of 8 (282mg, 1.0mmol) in 5mL anhydrou sphosphorus oxychloride was added the appropriate N-substituted 2-chloroacetamides 10 (1.05mmol). After stirring for 2-4h under reflux, excess phosphorus oxychloride was removed at reduced pressure to afford an oily residue, which was purified through column chromatography with petroleum ether/acetone 5:1 (v/v) as eluent to give target compounds Ia-w. Method B. To a solution of 8 (282mg, 1.0mmol) and the appropriately α-bromoketones 12 (1.05mmol) in 5mL anhydrous ethanol was added K2CO3 (152mg, 1.1mmol). The reactions were stirred under reflux for 0.5-4h. After reaction completed, the solution was cooled and poured slowly in 20mL water. Precipitate was filtered, washed with water and recrystallized from EtOH to provide target compounds Ix-as.
 

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