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Chemical Structure| 31835-53-7 Chemical Structure| 31835-53-7

Structure of 31835-53-7

Chemical Structure| 31835-53-7

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Product Details of [ 31835-53-7 ]

CAS No. :31835-53-7
Formula : C11H11NO
M.W : 173.21
SMILES Code : COC1=CC(C)=NC2=CC=CC=C12
MDL No. :MFCD00160586

Safety of [ 31835-53-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 31835-53-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31835-53-7 ]

[ 31835-53-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 31835-53-7 ]
  • [ 5780-66-5 ]
  • C16H13N3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
83% With toluene-4-sulfonamide; In toluene; at 120℃; for 12h;Inert atmosphere; A solution of 4-methoxy-2-methylquinoline (100 mg, 0.57 mmol), p-toluenesulfonamide (98.85 mg, 0.57 mmol) and pyrazine-2-carbaldehyde (61.5 mg, 0.57 mmol) in toluene (0.5 mL) was refluxed at 120° C. for 12 h in a reaction tube under nitrogen. After the mixture was cooled to room temperature, the solvent was removed under reduced pressure. Then the concentrate was purified by column chromatography with EtOAc/DCM (1:2, v/v) on silica gel, affording TZ-23-20 (124 mg, 83percent). 1H NMR (400 MHz, CDCl3) delta 8.67 (d, J=1.4 Hz, 1H), 8.49 (dd, J=2.2, 1.6 Hz, 1H), 8.36 (d, J=2.5 Hz, 1H), 7.96 (d, J=8.4 Hz, 1H), 7.83 (d, J=15.9 Hz, 1H), 7.70 (d, J=15.9 Hz, 1H), 7.56 (d, J=8.9 Hz, 1H), 7.39 (d, J=8.4 Hz, 1H), 7.32 (d, J=2.4 Hz, 1H), 7.08 (dd, J=8.9, 2.5 Hz, 1H), 3.87 (s, 3H). 13C NMR (101 MHz, CDCl3) delta 161.02, 154.52, 150.64, 149.95, 144.48, 144.36, 143.39, 136.23, 134.74, 129.19, 128.47, 123.05, 120.04, 118.67, 107.10, 55.50.
 

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