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Chemical Structure| 321-24-4 Chemical Structure| 321-24-4

Structure of 321-24-4

Chemical Structure| 321-24-4

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Product Details of [ 321-24-4 ]

CAS No. :321-24-4
Formula : C8H6ClFO2
M.W : 188.58
SMILES Code : O=C(Cl)C1=CC=C(OC)C=C1F
MDL No. :MFCD08146649

Safety of [ 321-24-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 321-24-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 321-24-4 ]

[ 321-24-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 321-24-4 ]
  • [ 1193-24-4 ]
  • [ 1516898-07-9 ]
YieldReaction ConditionsOperation in experiment
87% With triethylamine; In dichloromethane; at 25℃; General procedure: According to the conventional manufacturing method of the present inventors [16], under the condition containing two equivalents of triethylamine in dichloromethane at 25 , 4,6- dihydroxy-pyrimidine with 2 equivalents of Compound 2 by acylating a new and compounds 4, 6-pyrimidyl di (2-halo-benzoate) (compound 3) is prepared. After evaporation of dichloromethane, the mixture is dissolved in anhydrous THF, to remove the triethylamine hydrochloride by filtration. The concentrated residue was purified by short length silica gel (Davisil, pH = 7) was purified by column chromatography, or the Compound 3 is prepared by purification was recrystallized with 75% EtOAc / n- hexane
 

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