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[ CAS No. 325775-44-8 ]

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2D
Chemical Structure| 325775-44-8
Chemical Structure| 325775-44-8
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Product Details of [ 325775-44-8 ]

CAS No. :325775-44-8MDL No. :MFCD01861762
Formula : C9H18N2O2 Boiling Point : 260.6°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :186.25Pubchem ID :10679125
Synonyms :

Computed Properties of [ 325775-44-8 ]

TPSA : 55.6 H-Bond Acceptor Count : 3
XLogP3 : 0.2 H-Bond Donor Count : 1
SP3 : 0.89 Rotatable Bond Count : 3

Safety of [ 325775-44-8 ]

Signal Word:WarningClass:
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338UN#:
Hazard Statements:H302-H315-H319-H335Packing Group:
GHS Pictogram:

Application In Synthesis of [ 325775-44-8 ]

  • Upstream synthesis route of [ 325775-44-8 ]
  • Downstream synthetic route of [ 325775-44-8 ]

[ 325775-44-8 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 142253-54-1 ]
  • [ 325775-44-8 ]
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[2] Patent: US2003/229226, 2003, A1, . Location in patent: Page 20
  • 2
  • [ 141699-55-0 ]
  • [ 325775-44-8 ]
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
  • 3
  • [ 141699-58-3 ]
  • [ 325775-44-8 ]
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
  • 4
  • [ 325775-44-8 ]
  • [ 1173206-71-7 ]
YieldReaction ConditionsOperation in experiment
18 g With hydrogenchloride In ethanol; water To a solution of l-Boc-3-(aminomethyl)-azetidine (15.5 g, 82.9 mmol) in EtOH (250 mL) was slowly added aq. HCl (1.0 M, 83 mL). The solvent was removed in vacuo at 38 °C, providing the hydrochloride salt of the amine as a white solid (18.0 g).
18 g With hydrogenchloride In ethanol; water To a solution of l-Boc-3-(aminomethyl)-azetidine (15.5 g, 82.9 mmol) in EtOH (250 mL) was slowly added aq. HC1 (1.0 M, 83 mL). The solvent was removed in vacuo at 38 °C, providing the hydrochloride salt of the amine as a white solid (18.0 g).
Reference: [1] Patent: WO2013/36665, 2013, A1, . Location in patent: Paragraph 00173
[2] Patent: WO2013/36669, 2013, A1, . Location in patent: Paragraph 00266
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