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Chemical Structure| 32605-06-4

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Product Details of [ 32605-06-4 ]

CAS No. :32605-06-4
Formula : C6H7N3O2
M.W : 153.14
SMILES Code : O=[N+](C1=NC=CC=C1NC)[O-]
MDL No. :MFCD00223336
InChI Key :NCJOHCIQXAGJBV-UHFFFAOYSA-N
Pubchem ID :555983

Safety of [ 32605-06-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P261-P280-P305+P351+P338

Application In Synthesis of [ 32605-06-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 32605-06-4 ]

[ 32605-06-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32605-06-4 ]
  • [ 56291-51-1 ]
YieldReaction ConditionsOperation in experiment
97% With hydrogen;palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; for 7h; N-Methyl-2-nitropyridin-3-amine (14.1 g, 0.092 mol) was suspended under vigorous stirring in 1 ,2-dimethoxyethane/methanol mixture (1 :1 , 400 mL). The reaction apparatus was flushed with dry nitrogen. The catalyst (Pd/C 10%, 1.4 g) was added to the mixture. Hydrogen was bubbled through the suspension for 7 h. The reaction mixture was diluted with chloroform (300 mL) and passed through a filter with Celite (upper layer, 3 cm) and silica gel (lower layer, 5 cm, diameter 13 cm) to remove the catalyst. The layers were washed with chloroform/methanol mixture (1:1, 500 mL). The solvent was removed under reduced pressure, and the residue was mixed with acetonitrile. The mixture was concentrated under reduced pressure to give N-Methylpyridine-2,3-diamine (11.05 g, 97%, 0.09 mol). The product was used for the next stage without additional purification.
With hydrogen;palladium on activated charcoal; In methanol; for 4h; Step 2: N3-methylpyridine-2,3-diamineN-methyl-2-nitropyridin-3-amine (535 mg, 3.49 mmol) was dissolved in MeOH (50 ml) and treated with Pd-C (100 mg, 0.094 mmol). The solution was placed under a positive pressure of H2 for 4 hours and then filtered. The filtrate was concentrated in vacuo to afford the title compound which was used in the next step without further purification; 1H NMR (400MHz, DMSO) δ 7.28 (1 H, m), 6.50 (2H, m), 5.36 (2H, s), 4.84 (1 H, m), 2.69 (3H, d).
 

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Related Parent Nucleus of
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