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CAS No. : | 327-97-9 | MDL No. : | MFCD00003862 |
Formula : | C16H18O9 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | CWVRJTMFETXNAD-JUHZACGLSA-N |
M.W : | 354.31 | Pubchem ID : | 1794427 |
Synonyms : |
3-O-Caffeoylquinic acid;Heriguard;3transCaffeoylquinic acid;Chlorogenate;3CQA;3Caffeoylquinic acid;3Caffeoylquinate;3(34Dihydroxycinnamoyl)quinic acid;3(34Dihydroxycinnamoyl)quinate;NSC-407296
|
Num. heavy atoms : | 25 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.38 |
Num. rotatable bonds : | 5 |
Num. H-bond acceptors : | 9.0 |
Num. H-bond donors : | 6.0 |
Molar Refractivity : | 83.5 |
TPSA : | 164.75 Ų |
GI absorption : | Low |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -8.76 cm/s |
Log Po/w (iLOGP) : | 0.87 |
Log Po/w (XLOGP3) : | -0.42 |
Log Po/w (WLOGP) : | -0.75 |
Log Po/w (MLOGP) : | -1.05 |
Log Po/w (SILICOS-IT) : | -0.61 |
Consensus Log Po/w : | -0.39 |
Lipinski : | 1.0 |
Ghose : | None |
Veber : | 1.0 |
Egan : | 1.0 |
Muegge : | 2.0 |
Bioavailability Score : | 0.11 |
Log S (ESOL) : | -1.62 |
Solubility : | 8.5 mg/ml ; 0.024 mol/l |
Class : | Very soluble |
Log S (Ali) : | -2.58 |
Solubility : | 0.942 mg/ml ; 0.00266 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | 0.4 |
Solubility : | 894.0 mg/ml ; 2.52 mol/l |
Class : | Soluble |
PAINS : | 1.0 alert |
Brenk : | 2.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 4.16 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
dextransucrase; In water; dimethyl sulfoxide; at 30℃; for 22h;pH 5.2;Sodium acetate buffer; Calcium chloride; Enzymatic reaction;Product distribution / selectivity; | Example 9Enzymatic Synthesis of O-alpha-D-Glycosides of Caffeic Acid Phenethyl Ester, Chlorogenic Acid and 3,4-DihydroxybenzophenoneReaction media were prepared as described in example 1, Taxifolin being replaced by Caffeic acid Phenethyl ester (SIGMA, reference C8221), or by Chlorogenic acid (SIGMA, reference C3878) or by 3,4-dihydroxybenzophenone (ALDRICH, reference 579815) and the DMSO concentrations were 15% and 25% v/v.After 6 hours of incubation, a sample of each reaction medium was diluted 5 times with a solution containing methanol and water in the proportions of 40/60 and then analysed using the HPLC equipment previously described with a combination of eluant A (deionized water containing 1% v/v acetic acid) and eluant B (HPLC grade methanol containing 1% v/v acetic acid) as reported hereafter.The results are reported in the following table. Glucosyl acceptor (DMSO 15 and Retention time, min Retention time, min Analysis 25%) Identification Identification conditions Caffeic acid 20.15 17.42 and 16.88: majoritary G2 Phenethyl ester Caffeic acid products Phenethyl ester 18.42, 15.65, 14.22 and 13.77 O-alpha-glucosides of Caffeic acid Phenethyl ester Chlorogenic acid 15.53 11.00 and 10.67 G1 Chlorogenic acid Chlorogenic acid mono-O-alpha- glucoside and Chlorogenic acid di-O-alpha-glucoside 3,4- 32.35 27.98 and 27.68 G1 Dihydroxybenzo- 3,4-Dihydroxybenzo- 3,4-Dihydroxybenzophenone O- phenone phenone alpha-glucoside and 3,4- Dihydroxybenzophenone di-O- alpha-glucoside Analysis Conditions:G1: see example 8G2: flow rate 1 ml/min; from 0 to 20 min: B increases linearly from 40 to 80%; from 20 to 22 min: B is stable at 80%; from 22 to 27 min: B decreases linearly from 80 to 40%.It is thus possible according to the described method to synthesize the new glucosylated derivatives of Caffeic acid Phenethyl ester, Chlorogenic acid and 3,4-Dihydroxybenzophenone: the resulting products are a family of substances containing at least a monoglucosylated derivative. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | General procedure: To a solution of each selected compound 5-12 (2 mmol) in DMA (15 mL), triethylamine-sulfur trioxide adduct (2-8 equiv/OH) was added and the suspension was heated at 65 C for 24 h. The mixture was poured into acetone (150 mL) under basic conditions (few mL of triethylamine) and left at 4 C for 24 h. The crude oil formed was washed with acetone and ether, and dissolved in aqueous solution of 30% sodium acetate (5 mL). Generally, the suspension was added drop-wise in ethanol to precipitate the sodium salt of the sulfated derivative. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Laccase DAIWA Y120; In water; at 50℃; for 0.516667h;Enzymatic reaction; | Quercetin 2 hydrate (500 mg) and <strong>[327-97-9]chlorogenic acid</strong> (250 mg) were dissolved in purified water (1000 mL), and the mixture was warmed in an incubator at 50 C. for 1 minute. Laccase DAIWA Y120 (100 mL, Amano Enzyme Inc.) prepared to 5 mg/mL was added and the mixture was stirred for 1 minute. Ethanol (1000 mL) was further added to quench the enzyme reaction. This reaction mixture was concentrated to dryness under reduced pressure, the sample was dissolved in purified water, and the solution was loaded on Sep-Pak C18 (Waters), washed with purified water, and eluted with 30% aqueous ethanol solution (100 mL). 40% Ethanol-eluted fraction was concentrated to dryness under reduced pressure, the fraction was dissolved in 50% aqueous ethanol solution (2 mL), and the solution (500 muL) was injected in 4 portions and purified by HPLC. Two components (10 mg and 3 mg) having a molecular weight of 654 were obtained from the fractions with retention time 33.7 minutes and 34.4 minutes. The apparatus and measurement conditions of HPLC are shown below. LC/MS was used for the detection of the component having a molecular weight of 654 by HPLC, and UV spectrum was simultaneously measured by a photodiode array detector (see FIGS. 7 to 9). The apparatus and measurement conditions of LC/MS and photodiode array detector are shown below.HPLC apparatus:pump: PU-2087 PLUS (manufactured by JASCO Corporation) detector: Hitachi Lachrom Elite L-2455 (manufactured by Hitachi, Ltd.)autoinjector: AS-2057 PLUS (manufactured by JASCO Corporation) fraction collector: ADVANTEC SF-3120 (manufactured by ADVANTEC)HPLC measurement condition:column: CAPCELL PAK AQ S-5 mum, 50×250 mm (manufactured by Shiseido Co., Ltd.)solvent: solution of 0.05% trifluoroacetic acid and 25% acetonitrile in waterflow rate: 30 mL/minutedetection wavelength: 280 nmLC/MS analysis conditions:column: CAPCELL PAK AQ S-3 mum, 2×250 mm (manufactured by Shiseido Co., Ltd.)gradient conditions: 0 minute (SOLUTION A/SOLUTION B=100:0), 100 minutes (SOLUTION A/SOLUTION B=0:100), injection volume: 1 muL, flow rate: 0.2 mL/minute, solvent: SOLUTION A solution of 0.05% trifluoroacetic acid-10% acetonitrile in water, SOLUTION B solution of 0.05% trifluoroacetic acid and 80% acetonitrile in water1H-NMR (400 MHz, MeOH-d4): shown in Table 1.13C-NMR (100 MHz, MeOH-d4): shown in Table 2.As the NMR measurement device, Bruker Avance 400 (400 MHz, Bruker BioSpin KK) was used. The attribution of which carbon to which each proton is bonded was determined on the basis of the measurement by two-dimensional NMR (HSQC), and the assumed whole structure was attributed by two-dimensional NMR (HMBC). From the results of NMR analysis of each component, the difference was assumed to be any of (compound 5) or (compound 6) in a flat plane structure; however, (compound 5) and (compound 6) cannot be distinguished by NMR analysis |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfur trioxide trimethylamine complex; In N,N-dimethyl-formamide; acetonitrile; at 100℃;Microwave irradiation; | Chemical Synthesis of Diversified Library of Sulfated Molecules. The polyphenolic precursors of the sulfated molecules were either commercially available as silibinin (1), <strong>[327-97-9]chlorogenic acid</strong> (3), and pentagalloyl glucopyranoside (5) or were chemically synthesized as reported earlier for polyphenolic 1,2,3,4-tetrahydroisoquinoline (THIQ) derivatives (7-14) (see Figure 1). 10,11 Briefly, synthesis of polyphenolic THIQ derivatives was achieved in quantitative yields using Horner-Wadsworth-Emmons and Pictet-Spengler reactions followed by EDCI-mediated amidation and BBr3-assisted deprotection10. Sulfated silibinin (SS, 2), and sulfated <strong>[327-97-9]chlorogenic acid</strong> (SCA, 4) were synthesized by the microwave-assisted synthesis developed earlier.11 Briefly, the polyphenolic precursors (1, 3, and 5) and trimethylamine-sulfur trioxide (5 equivalents/-OH group) were mixed in equivolume mixture of DMF and CH3CN (3 mL) in microwave tube. The reaction tube was sealed and microwaved (CEM-discover microwave synthesizer) for 0.5-2 h at 100 C. Sulfated THIQ derivatives were synthesized in an equivolume mixture of DMF and CH3CN (3 mL) containing the trimethylamine-sulfur trioxide complex (6 equivalents/-OH group) which was heated for 5 h at 80 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | In methanol; for 0.25h;pH 5.0;Inert atmosphere; Schlenk technique; | A quantity of 0.125 mmol of <strong>[327-97-9]chlorogenic acid</strong> (chlorog) was dissolved in 3mL of a methanol:water (0.5:3) proportion on which an appropriate volume of an aqueous solution of VOCl2 (50%) was added to obtain a 1:1 (L:M) ratio. The resulting mixture was stirred for 15 min and the pH was adjusted to a value of 5 with a 1 M NaOH solution. After this time, addition of isopropyl alcohol in excess produced a violet precipitate which was filtered by suction and washed several times with the same alcohol. Finally it was oven-dried at 60 C. Yield: 50%. Anal.C16H29O17VNa. Calcd for: C, 33.8, H, 5.1, V, 9.0; Na, 4.1%. Exp: C, 33.5, H5.2, V, 9.2; Na, 4.2%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium azide; In aq. phosphate buffer; at 60℃; for 24h;pH 8.0; | General procedure: alpha-La (1.0%, w/w), CA (0.2%, w/w) and EGCG (0.2%, w/w) were dispersed in 50 mM phosphate buffer (pH 8.0), separately. The stock solution of alpha-La was kept overnight to ensure complete dispersion and dissolution, while sodium azide (0.2%, w/w) was added to prevent microbial growth. In order to prepare alpha-La-CA or EGCG covalent complex, 25 ml of CA or EGCG solution were added to 25 ml of alpha-La solution. 0.5% alpha-La solution and 0.1% CA or EGCG solutions were prepared with phosphate buffers as controls. All the samples were incubated at 60 C. Thereafter, alpha-La-CA or EGCG covalent complex, incubated for 24 h, was dialyzed for 48 h to remove free phenolic compounds (molecular weight cutoff 12,000-14,000 Da). Then all the samples were freeze-dried and were subjected to further analyses. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Novozym 435; In tert-Amyl alcohol; for 168h;Darkness; Molecular sieve; Enzymatic reaction; | 3-O palmitoyl <strong>[327-97-9]chlorogenic acid</strong> is one of the two products (3-O-palmitoyl <strong>[327-97-9]chlorogenic acid</strong> and 4-O-palmitoyl <strong>[327-97-9]chlorogenic acid</strong>) from the Novozym 453-catalyzed esterification of <strong>[327-97-9]chlorogenic acid</strong> with palmitic acid. Their synthesis and purification were performed as previously described (Lorentz et al., 2010). Briefly, <strong>[327-97-9]chlorogenic acid</strong>, palmitic acid and Novozym 435 were dried for two days over P2O5 before use. In these conditions, the initial water activity (aw) of the reaction medium, determined using an AqualabLite (Decagon Devices Inc., USA), was below 0.2. The reaction was carried out in 2-mL Eppendorf tubes in the dark. The reaction mixture consisted of 28 mumol of <strong>[327-97-9]chlorogenic acid</strong> and 1.12 mmol of palmitic acid (substrate ratio of 40) in 1 mL of 2-methyl-2-butanol (2M2B). Palmitic acid and <strong>[327-97-9]chlorogenic acid</strong> were first solubilized for 12 h in 2M2B under stirring at 1000 rpm and at 60 C in an Eppendorf Thermomixer (Roucaire, France). Then, 200 mg of molecular sieves (3 ), previously dried overnight at 200 C, was added and the reaction was initiated by addition of 40 mg of enzyme. After 7 days of reaction, the immobilized enzyme and molecular sieves were filtered off (0.22 mum), the solvent was evaporated under vacuum and 3-O-palmitoyl <strong>[327-97-9]chlorogenic acid</strong> and 4-O-palmitoyl <strong>[327-97-9]chlorogenic acid</strong> were isolated by Sephadex LH-20 chromatography using chloroform/methanol (70/30, v/v) as the eluent. Purification was completed by means of preparative TLC. As determined by HPLC, the final product was at least 98% pure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With Amberlite IR120 H; In methanol; at 55℃; for 9h; | In a 500-mL glass vessel, 10 mmol of 5-CQA was diluted in 240 mL of methanol. Amberlite IR120 H (10 g), previously dried at 110 C for 48 h, was added to the reaction mixture, which was then stirred in an orbital shaker (250 rpm) for 9 h at 55 C. After cooling to room temperature, the reaction medium was filtered on a 1.6-mum glass microfiber filter (Whatman International Ltd., Maidstone, England). Methanol was then evaporated under vacuum. Chloroform (150 mL) was added, and the solution was dried over sodium sulfate, filtered on a 1.6-mum glass microfiber filter and evaporated under vacuum at 50 C. The powder obtained was identified by mass spectrometry. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer; at 24.84℃;pH 7.4;Thermodynamic data; | General procedure: Stock solutionsofmilkproteinswerepreparedin0.01molL 1Tris-HCl, pH7.4.Themolecularweightsof alpha-CN, beta-CN,kappa-CN, alpha-LA, and beta-LG are24,24,19,14,and18kDa,respectively.[11] Milk proteinconcentrationwaskeptconstant(1.010 5 mol L 1). CHLOconcentrationwasvariedfrom0.2510 5 to 6.010 5 mol L 1. Fluorescenceemissionspectra wererecordedat300-450nmfollowingexcitationat281nmat298or310K.Theintrinsicfluorescenceemissionof proteinwasmonitoredat342nmforcaseinsand322nmfor wheyproteins.Forfluorescencemeasurements,a5-nmband passwasusedforexcitationandemission.[12] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer; at 24.84℃;pH 7.4;Thermodynamic data; | General procedure: Stock solutionsofmilkproteinswerepreparedin0.01molL 1Tris-HCl, pH7.4.Themolecularweightsof alpha-CN, beta-CN,kappa-CN, alpha-LA, and beta-LG are24,24,19,14,and18kDa,respectively.[11] Milk proteinconcentrationwaskeptconstant(1.010 5 mol L 1). CHLOconcentrationwasvariedfrom0.2510 5 to 6.010 5 mol L 1. Fluorescenceemissionspectra wererecordedat300-450nmfollowingexcitationat281nmat298or310K.Theintrinsicfluorescenceemissionof proteinwasmonitoredat342nmforcaseinsand322nmfor wheyproteins.Forfluorescencemeasurements,a5-nmband passwasusedforexcitationandemission.[12] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer; at 24.84℃;pH 7.4;Thermodynamic data; | General procedure: Stock solutionsofmilkproteinswerepreparedin0.01molL 1Tris-HCl, pH7.4.Themolecularweightsof alpha-CN, beta-CN,kappa-CN, alpha-LA, and beta-LG are24,24,19,14,and18kDa,respectively.[11] Milk proteinconcentrationwaskeptconstant(1.010 5 mol L 1). CHLOconcentrationwasvariedfrom0.2510 5 to 6.010 5 mol L 1. Fluorescenceemissionspectra wererecordedat300-450nmfollowingexcitationat281nmat298or310K.Theintrinsicfluorescenceemissionof proteinwasmonitoredat342nmforcaseinsand322nmfor wheyproteins.Forfluorescencemeasurements,a5-nmband passwasusedforexcitationandemission.[12] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer; at 24.84℃;pH 7.4;Thermodynamic data; | General procedure: Stock solutionsofmilkproteinswerepreparedin0.01molL 1Tris-HCl, pH7.4.Themolecularweightsof alpha-CN, beta-CN,kappa-CN, alpha-LA, and beta-LG are24,24,19,14,and18kDa,respectively.[11] Milk proteinconcentrationwaskeptconstant(1.010 5 mol L 1). CHLOconcentrationwasvariedfrom0.2510 5 to 6.010 5 mol L 1. Fluorescenceemissionspectra wererecordedat300-450nmfollowingexcitationat281nmat298or310K.Theintrinsicfluorescenceemissionof proteinwasmonitoredat342nmforcaseinsand322nmfor wheyproteins.Forfluorescencemeasurements,a5-nmband passwasusedforexcitationandemission.[12] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In aq. buffer; at 24.84℃;pH 7.4;Thermodynamic data; | General procedure: Stock solutionsofmilkproteinswerepreparedin0.01molL 1Tris-HCl, pH7.4.Themolecularweightsof alpha-CN, beta-CN,kappa-CN, alpha-LA, and beta-LG are24,24,19,14,and18kDa,respectively.[11] Milk proteinconcentrationwaskeptconstant(1.010 5 mol L 1). CHLOconcentrationwasvariedfrom0.2510 5 to 6.010 5 mol L 1. Fluorescenceemissionspectra wererecordedat300-450nmfollowingexcitationat281nmat298or310K.Theintrinsicfluorescenceemissionof proteinwasmonitoredat342nmforcaseinsand322nmfor wheyproteins.Forfluorescencemeasurements,a5-nmband passwasusedforexcitationandemission.[12] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34.5% | With hydrogenchloride; In methanol; water; at 60℃; for 6h;Large scale; | 1, a hidden <strong>[327-97-9]chlorogenic acid</strong> preparation method, comprising the following steps: (1) heating the <strong>[327-97-9]chlorogenic acid</strong> 200g, plus 10 times volume concentration is 50% methanol, plus 20 times 1mol/L hydrochloric acid, in the 60 C water bath stirring reaction on 6h, cooled to the room temperature after the reaction, the reaction liquid obtained; (2) reaction in the fluid adds 1mol/LNaOH solution to adjust pH to neutral, 50 C the following concentrate under reduced pressure to dry, adding methanol to dissolve, the separated white solid cvvhdf, the filtrate 50 C the following concentrate under reduced pressure to dry, a small amount of water is dissolved, cvvhdf, to obtain filtrate; (3) heating the filtrate is inverting C 18 column pre-processing, water washing, collecting concentrated water wash liquid, centrifugal, the 0.45 mum membrane, prepared by utilizing industrial preparation chromatography purity of 98.7% cryptophyta<strong>[327-97-9]chlorogenic acid</strong> 68.5g, yield is 34.3%.The industry for preparing stratography chromatographic condition: chromatographic column is reversed-phase C18 chromatography column (80×600 mm), flow rate is 60 ml/min, wavelength is 326 nm, mobile phase is acetonitrile (A) - 0.5% formic acid solution (B), gradient elution, whereas 5.0 g. Gradient elution conditions: 0-30min, 8% - 30% A; 30-35min, 30% - 100% A. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With toluene-4-sulfonic acid; In acetone; at 20℃; for 0.5h; | To a suspension of <strong>[327-97-9]chlorogenic acid</strong> (7.0 g, 19.8 mmol) in dry acetone (60 mL) and DMP (40 mL),catalytic amount of TsOH (50 mg, 0.26 mmol) was added. Then the reaction mixture was stirred atroom temperature for 30 min. Reaction was monitored by TLC. The crude mixture was neutralizedwith Na2CO3 powder to pH 6. Then the suspension was filtered out and the filtrate was evaporatedand the crude product was subjected to column chromatography (eluent: PE-EtOAc, 1:1) to offer apure light-yellow solid compound 5 (6.8 g, 87% yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84.95% | In methanol; ethanol; at 20℃; for 2h; | Add <strong>[327-97-9]chlorogenic acid</strong> (5.0g, 14.11mmol) to the reaction flask, add absolute ethanol (50.0ml) to dissolve, and slowly add ethanolamine (0.86g, 14.08mmol) / absolute methanol (2.0ml) solution at room temperature After the dropwise addition, the reaction was stirred at room temperature for 2h, filtered, and the filter cake was washed with an appropriate amount of absolute ethanol and dried under vacuum at 40 C to obtain <strong>[327-97-9]chlorogenic acid</strong> ethanolamine salt, white powder 4.98g, yield: 84.95% |
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P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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