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Chemical Structure| 32813-24-4 Chemical Structure| 32813-24-4

Structure of 32813-24-4

Chemical Structure| 32813-24-4

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Product Details of [ 32813-24-4 ]

CAS No. :32813-24-4
Formula : C8H14N2S
M.W : 170.28
SMILES Code : S=C=NCCN1CCCCC1
MDL No. :MFCD00041232

Safety of [ 32813-24-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 32813-24-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 32813-24-4 ]

[ 32813-24-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32813-24-4 ]
  • [ 1397-89-3 ]
  • [ 1513872-58-6 ]
YieldReaction ConditionsOperation in experiment
35 mg Example 6. Synthesis of N-thioureidyl derivatives of Amphotericin B.; 200 mg (0.22 mmol) of Amphotericin B is dissolved in 4 ml of dimethyl formamide (DMF) in100 ml round-bottomed flask equipped with a magnetic stirrer. The solution is cooled to0 o C and 0.029 ml (0.21 mmol) of triethylamine (TEA) is slowly added. After 10 minutes0.25 mmol of the appropriate isothiocyanate is added and the reaction mixture is warmed toroom temperature. The reaction progress is monitored by thin layer chromatography (TLC) onSilica Gel (60 F254, Merck) in chloroform: methanol: water (10:6:1 v/v) solvent system.After then the reaction mixture is added dropwise to 150 ml of diethyl ether. The resulting,pale yellow precipitate is filtered under reduced pressure on a Millipore funnel. The crudeproduct is twice washed with diethyl ether (2x50 ml) and then dried in a vacuum desiccator.The residue is purified by column chromatography on normal phase, where the solid phase isSilica Gel and solvent system is chloroform: methanol (gradient from 20% to 55% ofmethanol). The fractions with pure product were collected and combined, then evaporatedunder reduced pressure at temperature not exceeding 35 C. The following derivatives ofAmphotericin Bare obtained:a) In the reaction with 2-piperidin-1-yl-ethylisothiocyanate is obtained 35 mg of N-[3-(2-piperidin -1-yl )ethyl ]thioureidyl] amphotericin B ( A22) TLC Rr= 0.4; UV-vis: Amax (MeOH) 406; 382; 363 nm; Ei~n (MeOH, A= 406nm) = 1230(theoretically for CssHs7N3017S is 1352); MS-ESI found m/z: 1094.5 [M+Ht; calculated forCssHs7N3017S [Mt 1093.6
 

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