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Chemical Structure| 330473-75-1 Chemical Structure| 330473-75-1

Structure of 330473-75-1

Chemical Structure| 330473-75-1

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Product Details of [ 330473-75-1 ]

CAS No. :330473-75-1
Formula : C5H7BrN2O
M.W : 191.03
SMILES Code : OC1=CC=C(N)N=C1.[H]Br
MDL No. :MFCD14586323

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Application In Synthesis of [ 330473-75-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 330473-75-1 ]

[ 330473-75-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 558-42-9 ]
  • [ 330473-75-1 ]
  • [ 1253911-35-1 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; In N,N-dimethyl-formamide; at 140℃; for 3h;Microwave; Step 1.Preparation of I-(6-amino-pyridin-3-yloxy)-2-methyl-propan-2-olTo a microwave flask containing 6-aminopyridin-3-ol hydrobromide (700 mg, 3.66 mmol) and 1-chloro-2-methyl-2-propanol (597 mg, 5.5 mmol) in anhydrous dimethylformamide (17 ml) was added cesium carbonate (3.7 g, 11.4 mmol) and the material was heated in a microwave oven at 140° C. for 3 hours.The vial was cooled to ambient and the solvent was concentrated in vacuo (rotary evaporator/mechanical pump).The residue was taken up in methylene chloride and filtered to remove insolubles, rinsing well with methylene chloride.The crude material was purified by HPLC on silica gel, eluting with a gradient of 2percent to 10percent methanol/methylene chloride to provide the desired product as a orange-brown viscous oil which solidified on standing (449 mg). MS (H+)=183 m/e.
 

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