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Chemical Structure| 335349-66-1 Chemical Structure| 335349-66-1

Structure of 335349-66-1

Chemical Structure| 335349-66-1

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Product Details of [ 335349-66-1 ]

CAS No. :335349-66-1
Formula : C7H7IN2O3
M.W : 294.05
SMILES Code : NC1=CC(OC)=C(I)C=C1[N+]([O-])=O
MDL No. :MFCD22570398

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Application In Synthesis of [ 335349-66-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 335349-66-1 ]

[ 335349-66-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 67-56-1 ]
  • [ 335349-57-0 ]
  • [ 335349-66-1 ]
YieldReaction ConditionsOperation in experiment
97% With potassium hydroxide; In dimethyl sulfoxide; at 30 - 60℃; for 4.0h;Large scale; Compound 2S <strong>[335349-57-0]2-nitro-4-iodo-5-chloroaniline</strong> (2200 g, 7.4 mol) was added to a solution of 7.3 L of dimethylsulfoxide (DMS0) and7.3 L methanol (Mu0H) mixed solution, then add K0H (1040g, 18.4mo 1),Temperature control at 30 C plus finish. And then heated to 60 C reaction 4h, TLC detection reaction is complete, then cooled to room temperature, the reaction solution into 10L of water, Stirred for 15min, filtered, the filter cake washed with water to neutral, drying the compound 3S 3-methoxy-4-iodo-5-nitro-aniline(2100 g, 7.14 mol) Yield 97%
  • 2
  • [ 335349-57-0 ]
  • [ 335349-66-1 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In methanol; dimethyl sulfoxide; Example E2 4-Iodo-5-methoxy-2-nitro-phenylamine Prepared from <strong>[335349-57-0]5-chloro-4-iodo-2-nitro-phenylamine</strong> (Example A1) (2.98 g, 10 mmol), methanol (10 mL) and KOH (1.45 g, 22 mmol) in DMSO (10 mL) according to the general procedure E. Obtained as an orange solid (2.9 g). MS (ISP) 295 [(M+H)+] and 312 [(M+NH4)+]; mp 189 C.
  • 3
  • [ 335349-66-1 ]
  • [ 55215-55-9 ]
YieldReaction ConditionsOperation in experiment
80% The compound 3 (1550g, 5.27 muM) added to the water: b nitrile=1:5 (volume ratio) of 10L solution, then adding a hydrated toluenesulfonates TsOH.H2 O (3615.0g, 19.0 muM), reaction liquid cooling to 0 C, dropping sodium nitrite (1085.0g, 15.7 muM) aqueous solution of the 2L, after and milling, stirring 1h, then the solution is dropped to KI (3061.0g, 18.4 muM) of the 2L in the aqueous solution, and milling the room temperature after reaction 12h. TLC detection after the reaction, the reaction liquid is poured into the water, stirring 30min, filtering, cake dissolve EA, saturated sodium thiosulfate solution washing, saturated sodium bicarbonate solution washing, saturated salt water washing, drying, turns on lathe does to obtain compound 4 (1700g, 4.2 muM), yield 80%
 

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