* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
2
[ 33631-02-6 ]
[ 2770-01-6 ]
Reference:
[1] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
3
[ 3243-24-1 ]
[ 33631-02-6 ]
[ 2770-01-6 ]
Reference:
[1] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
4
[ 33631-02-6 ]
[ 64-18-6 ]
[ 3243-24-1 ]
Reference:
[1] Recueil des Travaux Chimiques des Pays-Bas, 1949, vol. 68, p. 1013,1024
5
[ 88511-57-3 ]
[ 33631-02-6 ]
Yield
Reaction Conditions
Operation in experiment
83%
With hydrogen In DMF (N,N-dimethyl-formamide) at 20℃;
3d) 3,4-diamino-2-hydroxypyridine 11.0 g (71 mmol) of 4-amino-2-hydroxy-3-nitropyridine were dissolved in 150 ml of dimethylformamide and reduced by catalytic hydrogenation at ambient temperature (Pd/C 10percent). Yield: 83percent of theory. C5H7N3O (125.13) Mass spectrum: (M+H)+=126
3e) 2-Mercapto-3,5-dihydro-imidazo[4,5-c]pyridin-4-one A suspension of 5.0 g (39.96 mmol) of <strong>[33631-02-6]3,4-diamino-2-hydroxypyridine</strong> and 12.82 g (80.0 mmol) of potassium-ethyl xanthogenate in 100 ml of ethanol was refluxed for three hours. The mixture was then cooled to ambient temperature and combined with approx. 20 ml of diethyl ether. The precipitated product was filtered off, washed with approx. 10 ml of diethyl ether, dried, dissolved in approx. 30 ml of water and this solution was acidified with concentrated hydrochloric acid. The product precipitated was suction filtered, washed with 15 ml of water and dried at 50 C. Yield: 82% of theory. C6H5N3OS (167.19) Mass spectrum: (M+H)+=168 (M-H)-=166
With hydrogen;10% palladium on activated carbon; In DMF (N,N-dimethyl-formamide); at 20.0℃;
3d) 3,4-diamino-2-hydroxypyridine 11.0 g (71 mmol) of 4-amino-2-hydroxy-3-nitropyridine were dissolved in 150 ml of dimethylformamide and reduced by catalytic hydrogenation at ambient temperature (Pd/C 10%). Yield: 83% of theory. C5H7N3O (125.13) Mass spectrum: (M+H)+=126