Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 33631-05-9 | MDL No. : | MFCD04114161 |
Formula : | C5H6N2O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | HQNIMNQVKVPZES-UHFFFAOYSA-N |
M.W : | 110.11 | Pubchem ID : | 820936 |
Synonyms : |
|
Num. heavy atoms : | 8 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.0 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 30.66 |
TPSA : | 59.14 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.87 cm/s |
Log Po/w (iLOGP) : | 0.65 |
Log Po/w (XLOGP3) : | 0.15 |
Log Po/w (WLOGP) : | 0.38 |
Log Po/w (MLOGP) : | -0.45 |
Log Po/w (SILICOS-IT) : | 0.25 |
Consensus Log Po/w : | 0.2 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.17 |
Solubility : | 7.41 mg/ml ; 0.0673 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.95 |
Solubility : | 12.4 mg/ml ; 0.113 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -1.03 |
Solubility : | 10.3 mg/ml ; 0.0938 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.48 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
c. 2-Amino-4-pyridinol To a solution of 16.0 g of bromine in 280 ml of 10% aqueous potassium hydroxide at 20 is added, portionwise, 13.8 g of finely powdered 4-hydroxypicolinamide. The mixture is stirred during the addition and after the addition is complete until a clear solution forms. Subsequently, the internal temperature is gradually raised to 80, kept at 80 for 0.25 hour, and the solution is allowed to cool spontaneously to 20, and is then cooled to 0 by means of an ice bath. The cold solution is treated with glacial acetic acid until the pH is adjusted to 5.5. The precipitate that forms is filtered to give 2-amino-4-pyridinol as a colorless, microcrystalline powder. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (0.251 g, 2.28 mmol) in MeCN (4.0 ml.) at RT was added DB U (423 mul , 2.80 mmol) and after 30 min a solution of 1-fluoro-2-methoxy-4- nitrobenzene (300 mg, 1.75 mmol) in DMF (2.0 ml.) was added dropwise. The reaction mixture was maintained at RT for 1 hr and was then heated to 800C for 16 hr. After cooling to RT water (2.0 ml.) was added and the mixture was evaporated in vacuo. The residue was partitioned between DCM (30 ml.) and brine (20 ml.) and the organic layer was separated and dried (MgSO4) and was evaporated in vacuo. The residue was purified by flash column chromatography (SiO2, 40 g, EtOAc in isohexane, 20-100percent, gradient elution) to afford 4-(2- methoxy-4-nitrophenoxy)pyridin-2-amine as a bright yellow solid (234 mg, 50percent); R' 1.25 min (Method 2); m/z 262 (M+H)+ (ES+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (483 mg, 4.38 mmol) in MeCN (2.0 ml.) was added DBU (661 mul_, 4.38 mmol) and the reaction mixture maintained at RT until a homogeneous solution had formed at which time, 1-fluoro-3-methoxy-4-nitrobenzene (500 mg, 2.92 mmol) was added. The reaction mixture was kept at RT for 5hr, was heated to 800C for a further 16 hr. and was then cooled to RT, The reaction was diluted with water (5.0 ml.) and the mixture was evaporated in vacuo. The residue was partitioned between EtOAc (20 ml.) and water (20 ml.) and the aq layer was separated and extracted with EtOAc (20 ml_). The combined organic extracts were washed with brine (50 ml.) and dried (Na2SO4) and were evaporated in vacuo. The residue was purified by flash column chromatography (SiO2, 40 g, EtOAc in DCM, 0- 100%, gradient elution) to afford 4-(3-methoxy-4-nitrophenoxy)pyridin-2-amine as a yellow solid (420 mg, 55%); R1 1.30 min (Method 2); m/z 262 (M+H)+ (ES+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28% | With potassium carbonate; In dimethyl sulfoxide; at 75℃; for 72h; | Intermediate C2: 4-(2,3-Dimethyl-4-nitrophenoxy)pyridin-2 -amine.Intermediate C2 To a stirred solution of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (600 mg, 5.5 mmol) and 1 -fluoro-2,3-dimethyl-4- nitrobenzene (570 mg, 3.37 mmol) in DMSO (4.0 mL) was added K2C03 (1.00 g, 7.20 mmol) and the reaction mixture heated to 75C for 3 days. The resulting mixture was cooled to RT and was partitioned between water (50 mL) and EtOAc (75 mL). The aq layer was separated and extracted with EtOAc (75 mL) and the combined organic extracts were washed with water (3 x 50 mL) and brine (50 mL) and then dried and evaporated in vacuo. The residue was recrystallized from DCM to afford the title compound, Intermediate C2, as a tan solid (25 mg, 28%): R' 1 .40 min (Method 2); m/z 260 (M+H)+ (ES+). |
19% | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (339 mg, 3.07 mmol) in MeCN (4.0 ml.) at RT was added DBU (570 mul_, 3.78 mmol) and after 30 min a solution of 1-fluoro-2,3-dimethyl-4- nitrobenzene (400 mg, 2.36 mmol) in MeCN (2.0 ml.) was added dropwise. The reaction mixture was maintained at RT for 16 hr; DMF (2.0 ml.) was added and the mixture heated to 800C for 72 hr and then cooled to RT for 64 hr. The resulting mixture was evaporated in vacuo and the residue was partitioned between DCM (50 ml.) and brine (30 ml_). The organic layer was separated and dried (MgSO4) and was evaporated in vacuo. The residue was purified by flash column chromatography (SiO2, 40 g, EtOAc in isohexane, 20-100%, gradient elution and then SiO2, 12g, 50% EtOAc in isohexane, isocratic elution) to afford 4-(2,3-dimethyl-4- nitrophenoxy)pyridin-2-amine, as a yellow solid (1 17 mg, 19%); R' 1.47 min (Method 2); m/z 260 (M+H)+ (ES+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
44% | Intermediate H3: Lambda/-(4-(4-Amino-3-methylphenoxy)pyridin-2-yl)-2-methoxyacetamideTo a solution of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (355 mg, 3.22 mmol) in DMF (4.0 ml.) at 00C under nitrogen was added portionwise sodium hydride (60% dispersion in mineral oil, 193 mg, 4.83 mmol) and the reaction mixture warmed to RT for 2 hr, The mixture cooled to 00C and a solution of 4-fluoro-2-methyl-1 -nitrobenzene (500 mg, 3.22 mmol) in DMF (2.0 ml.) was added, dropwise and the reaction mixture warmed to RT for 16 hr. The resulting mixture was diluted with water (20 ml.) and was extracted with ethyl acetate (3 x 30 ml_). The combined organic extracts were washed with brine (20 ml_), then dried (MgSO4) and evaporated in vacuo and the residue was purified by flash column chromatography (SiC>2, 40 g, 25% EtOAc in DCM , isocratic elution) to afford 4-(3-methyl-4-nitrophenoxy)pyridin-2-amine as a yellow solid (351 mg, 44%); R1 1.20 min (Method 2); m/z 246 (M+H)+ (ES+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (750 mg, 6.81 mmol) in MeCN (10.0 mL) was added DBU (1 .34 mL, 8.91 mmol) and the mixture maintained at RT for 30 min until a solution was obtained. A solution of 2,3-dichloro-1 -fluoro-4-nitrobenzene (1 .10 g, 5.24 mmol) in MeCN (5.0 mL) was added and the reaction mixture kept at RT for 16 hr. The resulting mixture was concentrated in vacuo to ca 5 mL. and was then partitioned between water (40 mL) and EtOAc (30 mL). The aq layer was extracted with EtOAc (30 mL) and the combined organic extracts were washed with brine (30 mL), dried and then evaporated in vacuo. The residue was triturated with Et20 (20 mL) to afford the title compound, Intermediate C3, as a yellow solid (1.30 g, 79%); Rl 1.63 min (Method 2); m/z 300/302 (M+H)+, (ES+) | |
79% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20℃; for 16h; | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (750 mg, 6.81 mmol) in MeCN (10.0 mL) was added DBU (1.34 mL, 8.91 mmol) and the mixture maintained at RT for 30 min until a solution was obtained. A solution of 2,3-dichloro-1-fluoro-4-nitrobenzene (1.10 g, 5.24 mmol) in MeCN (5.0 mL) was added and the reaction mixture kept at RT for 16 hr. The resulting mixture was concentrated in vacuo to ca 5 mL. and was then partitioned between water (40 mL) and EtOAc (30 mL). The aq layer was extracted with EtOAc (30 mL) and the combined organic extracts were washed with brine (30 mL), dried and then evaporated in vacuo. The residue was triturated with Et2O (20 mL) to afford the title compound, Intermediate C3, as a yellow solid (1.30 g, 79%); Rt 1.63 min (Method 2); m/z 300/302 (M+H)+, (ES+) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20℃; for 1h; | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (228 mg, 2.07 mmol) in MeCN (1 .5 mL) was added DBU (310 mu, 2.07 mmol) and the mixture maintained at RT until all the solids were completely dissolved, when 4-fluoro-7-nitro-1 /-/-indazole (250 mg, 1 .380 mmol) was added in a single portion. The reaction mixture was kept at RT for 1 hr and was then partitioned between EtOAc (20 mL) and a mixture of brine (10 mL) and water (20 mL). The aq layer was extracted with EtOAc (2 x 10 mL) and the combined organic extracts were washed with brine (50 mL), dried and evaporated in vacuo. The residue was purified by flash column chromatography (Si02, 12g, EtOAc in DCM, 0-100%, then MeOH in EtOAc, 0-2%, gradient elution) to afford the title compound, Intermediate C2, as a yellow solid (65 mg, 16%); R' 1 .10 min (Method 2); m/z 272 (M+H)+ (ES+). |
16% | With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20℃; for 1h; | To a suspension of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (228 mg, 2.07 mmol) in MeCN (1.5 mL) was added DBU (310 muL, 2.07 mmol) and the mixture maintained at RT until all the solids were completely dissolved, when 4-fluoro-7-nitro-1H-indazole (250 mg, 1.380 mmol) was added in a single portion. The reaction mixture was kept at RT for 1 hr and was then partitioned between EtOAc (20 mL) and a mixture of brine (10 mL) and water (20 mL). The aq layer was extracted with EtOAc (2×10 mL) and the combined organic extracts were washed with brine (50 mL), dried and evaporated in vacuo. The residue was purified by flash column chromatography (SiO2, 12 g, EtOAc in DCM, 0-100%, then MeOH in EtOAc, 0-2%, gradient elution) to afford the title compound, Intermediate C2, as a yellow solid (65 mg, 16%); Rt 1.10 min (Method 2); m/z 272 (M+H)+ (ES+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Step A: Preparation of ethyl 7-hvdroxyimidazori,2-a1pyridine-3-carboxylate:To a chilled (0 C) solution of potassium 2-chloro-3-ethoxy-3-oxoprop-l-en-l-olate (16. 4 g, 86.3 mmol) in concentrated sulfuric acid (43.5 mmol) and ethanol (50 mL) was added 2- aminopyridin-4-ol (3 g, 27 mmol). The resulting mixture was warmed to ambient temperature and refluxed for 10 hours. The reaction was concentrated and suspended in EtOAc. The solids were isolated to afford 829 mg of pure product. The supernatant was concentrated, and subjected to chromatography on silica with 30% EtOAc/Hexanes as eluent to afford a second batch of desired product (5.8 g, 80 % purity) as a brown, viscous oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; | Mix <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (3.3 g, 30 mmol), 2-chloro-3-methyl-5-nitropyridine (5.17 g, 30 mmol) in anhydrous DMF (50 mL), add K2C03 (8.28 g, 60 mmol). Stir the reaction at 90C overnight. Concentrate under reduced pressure to give crude product. Purification by chromatography (silica gel, EtOAc:PE=l :l) affords the title compound (3.3 g, 45%). MS: (M+l): 247.1. |
45% | With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; | Mix <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (3.3 g, 30 mmol), 2-chloro-3-methyl-5-nitropyridine (5.17 g, 30 mmol) in anhydrous DMF (50 mL), add K2CO3 (8.28 g, 60 mmol). Stir the reaction at 90 C. overnight. Concentrate under reduced pressure to give crude product. Purification by chromatography (silica gel, EtOAc:PE=1:1) affords the title compound (3.3 g, 45%). MS: (M+1): 247.1. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
46.3% | In N,N-dimethyl-formamide; at 120℃; for 3h; | Mix <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (1.13 g, 10.3 mmol), 5-bromo-2,3-difluoro-pyridine (2 g, 10.3 mmol) in DMF (10 mL). Stir the mixture at 120C for 3 hrs. TLC (EtOAc:PE=l:l) shows the reaction is complete. Filter, add water (50 mL) to the filtrate, extract with EtOAc (50 mLx3). Combine the organic layers, dry over anhydrous Na2S04. Concentrate to give the crude product. Purification by chromatography (silica gel, EtOAc:PE=l:4) affords the title compound (1.35 g, 46.3%). MS: (M+l): 284. |
46.3% | In N,N-dimethyl-formamide; at 120℃; for 3h; | Mix <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (1.13 g, 10.3 mmol), 5-bromo-2,3-difluoro-pyridine (2 g, 10.3 mmol) in DMF (10 mL). Stir the mixture at 120 C. for 3 hrs. TLC (EtOAc:PE=1:1) shows the reaction is complete. Filter, add water (50 mL) to the filtrate, extract with EtOAc (50 mL*3). Combine the organic layers, dry over anhydrous Na2SO4. Concentrate to give the crude product. Purification by chromatography (silica gel, EtOAc:PE=1:4) affords the title compound (1.35 g, 46.3%). MS: (M+1): 284. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
32% | With triethylamine; In dichloromethane; at 10 - 20℃; for 16h; | Dissolve 2-amino-pyridin-4-ol (5 g, 45.4 mmol) in DCM (30 mL), add Et3N (13.8 g, 136 mmol) and then cyclopropanecarbonyl chloride (14.2 g, 136 mmol) dropwise while keeping the temperature below 10C. After addition, stir the reaction at room temperature for 16 hrs. Remove the solvent under reduced pressure, dissolve the residue in THF (40 mL), adjust pH=12 with IN NaOH solution. Stir the mixture for 3 hrs. Concentrate to give the crude product. Purification by chromatography (silica gel, EtOAc:MeOH=9:l) affords the title compound (2.6 g, 32%). |
32% | With triethylamine; In dichloromethane; at 10 - 25℃; for 16h; | Dissolve 2-amino-pyridin-4-ol (5 g, 45.4 mmol) in DCM (30 mL), add Et3N (13.8 g, 136 mmol) and then cyclopropanecarbonyl chloride (14.2 g, 136 mmol) dropwise while keeping the temperature below 10 C. After addition, stir the reaction at room temperature for 16 hrs. Remove the solvent under reduced pressure, dissolve the residue in THF (40 mL), adjust pH=12 with 1N NaOH solution. Stir the mixture for 3 hrs. Concentrate to give the crude product. Purification by chromatography (silica gel, EtOAc:MeOH=9:1) affords the title compound (2.6 g, 32%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
104 mg | With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 120℃; for 3h; | Preparation Example 427 A mixture of 5-chloro-6-ethyl-3-[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrazine-2-carboxamide (200 mg), <strong>[33631-05-9]2-amino-4-pyridinol</strong> (118 mg), cesium carbonate (348 mg), and N-methylpyrrolidone (2 mL) was stirred at 120 C. for 3 hours. The reactant was purified by silica gel column chromatography (eluent; chloroform:methanol=95:5-80:20, NH2 type: eluent; chloroform:methanol=99:1-98:2) and then washed with ethyl acetate to obtain 5-[(2-aminopyridin-4-yl)oxy]-6-ethyl-3-[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrazine-2-carboxamide (104 mg) as a yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
6.57% | With sodium acetate; In water; at 80℃; for 24h; | 2-Amino-4-hydroxypyridine (500mg, 4.54mmol) and sodium acetate trihydrate (2.20g, 16.2mmol) were suspended in 25mL deionised water and heated to 80C. Chloroacetaldehyde (50%m/m in water, 700muL, 4.46mmol) was added dropwise to the stirred reaction mixture. The reaction mixture was stirred under reflux for 24 hours and subsequently cooled to room temperature. The reaction mixture was neutralized by addition of aqueous ammonia solution and the solvent was evaporated until dryness. The remaining residue was purified by column chromatography using dichloromethane/methanol 20/1 as eluent. Yield 58.1mg, 6.57%. 1H NMR (DMSO-d6) delta 4.48 (dd, J1=2.1Hz, J2=10.5Hz, 1H), 4.71 (m, 1H), 5.64 (d, J=5.1Hz, 1H), 6.83 (d, J=7.3Hz, 1H), 7.49 (d, J=0.9Hz, 1H), 7.92 (d, J=1.1Hz, 1H), 8.55 (d, J=7.3Hz, 1H). 13C NMR (DMSO-d6) delta 69.23, 80.27, 100.87, 110.99, 112.67, 129.22, 132.06, 142.93, 157.82. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With caesium carbonate; In N,N-dimethyl acetamide; at 150℃; for 8h; | To a solution of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (1 10 mg, 1 mmol) in DMA (5 mL) was added bromocyclopropane (181 mg, 1.5 mmol) and CS2CO3 (1.6 g, 5 mmol). The resulting mixture was heated to 150C for 8hr. The reaction mixture was quenched with H20 and extracted with EA (10 mL x 3). The combined organic layers was dried over Na2S04, filtered and concentrated. The crude product was purified by flash chromatography (silica gel, 0-50% ethyl acetate in petroleum ether) to provide 4- cyclopropoxypyridin-2-amine (531-1) (93 mg, 62 %) as a yellow oil. LC-MS (ESI): mlz (M+l) 151.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | In ethanol; for 4h;Inert atmosphere; Reflux; | A solution of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (0.50 g, 4.54 mmol) and Intermediate 89A (1.03 g,6.81 mmol) in EtOH (10 mL) was stirred under N2 at reflux for 4 h. The solvent was removed. The crude product was purified by normal phase chromatography to provide Intermediate 89 (0.55 g, 60%) as a light tan solid. ?H NMR (500MHz, CD3OD) oe 9.35 (d, J7.4 Hz, 1H), 8.49 (s, 1H), 7.21 -7.11 (m, 2H), 4.47 (q,J=7.2 Hz, 2H), 1.43 (t,J=7.2Hz, 3H). LC-MS(ESI) m/z: 207.1 [M+H]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16% | Step 1: To a stirred solution of <strong>[33631-05-9]2-aminopyridin-4-ol</strong> (500 mg, 4.5 mmol) in DMF (5 mL) at rt was added K2CO3(940 mg, 6.8 mmol). The resulting mixture was stirred at rt for 20 min before allyl bromide (393 mL, 4.5 mmol) was added.The mixture was then stirred at rt overnight and heated at 60 C for 2 h. After cooling to rt, the mixture was partitionedbetween EtOAc and water, and the organic layer was washed with brine, dried over Na2SO4, and evaporated underreduced pressure. The residue was purified by silica gel chromatography eluting with EtOAc in hexanes to give 4-(allyloxy)pyridin-2-amine (110 mg, 16%) as a white solid. LCMS (ESI) m/z 151 (M+H)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | In ethanol; at 60℃;Inert atmosphere; | To a suspension of2-aminopyridin-4oi (1.00g. 9.08 mmoi) in EtOH (10 mL) at a was added E)ethyl 2chloro3hydroxyacryiate (2.05 g, 13.62 mrnol) dropwise. The reaction was stirred under N2 at 60 C overnight. The solvent was removed. The crude product was purified by flash chromatography (0% to 15% MeOFI/DCM gradient) to obtain ethyl 7-hydroxyimidazo[1,2ajpyridine.-3-carboxylate (1.18 g, 63 % yield), as a light brownsolid. ?H NMR (400MHz, Methanol-d4) d ppm 9.37 (dd, J=7.7, 0.4 Hz. 1Ff). 8.50 (s. 11-f), 723 7.13 (n, 2H), 4.50 (q.J=7.1 Hz, 2H), 1.45 (t, J:::7.0 Hz, 3H). MS (ESI) m/z: 207.0 (MH) |
Tags: 33631-05-9 synthesis path| 33631-05-9 SDS| 33631-05-9 COA| 33631-05-9 purity| 33631-05-9 application| 33631-05-9 NMR| 33631-05-9 COA| 33631-05-9 structure
[ 439146-20-0 ]
6-Chloro-4-methoxypyridin-2-amine
Similarity: 0.77
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :