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Chemical Structure| 3409-21-0 Chemical Structure| 3409-21-0

Structure of 3409-21-0

Chemical Structure| 3409-21-0

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Product Details of [ 3409-21-0 ]

CAS No. :3409-21-0
Formula : C13H17NO
M.W : 203.28
SMILES Code : O=C1C(CCN(C)C)CC2=CC=CC=C21
MDL No. :MFCD19302158

Safety of [ 3409-21-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 3409-21-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3409-21-0 ]

[ 3409-21-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 13925-00-3 ]
  • [ 3409-21-0 ]
  • [ 867035-87-8 ]
YieldReaction ConditionsOperation in experiment
To a solution of LDA (1 mL, 2 N solution in THF, 2 mmol) in Et20 (5 mL) at 0 °C, <strong>[13925-00-3]2-<strong>[13925-00-3]ethylpyrazine</strong></strong> (238 mg, 2.2 mmol) in Et2O (1 mL) was added slowly, and the reaction mixture was stirred at 0 °C for 30 minutes. A solution of 2-(2-dimethylamino- ethyl) -indan-1-one 2b (203 mg, 1 mmol) in Et20 (1 mL) was added. The resultant mixture was stirred at 0 °C for two hours. A small piece of chip ice was added to quench the reaction. The mixture was extracted with Et20, washed with NaHC03 aqueous solution, then extracted with 20percent HCI (2 x 5 mL). The combined HCI layers were heated to 100 °C for 1 hour. After cooling to room temperature, the mixture was neutralized with cooled NH40H and extracted with EtOAc. The organic layer was dried over Na2S04 and concentrated to give dimethyl- (2- [3 -( 1 -pyrazin-2-yl-ethyl)- I H-inden-2-yl] -ethyl ) amine 4-1 as a red oil which was purified by HPLC yielding the TFA salt. Chiral HPLC separation on 4-1 using a Chiraltech Chiralpak AD-H column and hexane: isopropyl alcohol 99: 1 (with 0.1 percent isopropylamine) as elutant yielded enantiomers 4-5 and 4-6. The following compounds were made according to this procedure: No. R1 R2b R3 MW MH+ tR (method) 4-1 Pyrazin-2-yl CH3 H 293.41 294.2 3.700 (2) 4-2 Pyrimidin-4-yl CH3 H 293.41 294.0 3.997 (2) 4-3 Pyrazin-2-yl H H 279.38 280.0 3.441 (2) 4-4 3-methoxy- CH3 H 323.44 324.1 4.602 (2) pyrazin-2-yl 4-5 Pyrazin-2-yl (S) -CH3 profile 1 H 293.41 294.1 4.091 (2) 4-6 Pyrazin-2-yl (R) -CH3 profile 1 H 293.41 294.1 4.057 (2) 4-7 3-methoxy- (R) -CH3 H 323.44 323.9 4.443 (2) pyrazin-2-y1 profile 2 4-8 3-methoxy- (S) -CH3 H 323.44 323.9 4.425 (2) pyrazm-2-yl profile 4-9 3-methyl-pyrazin-2-yl H H 293.41 294.0 3.530 (2) 4-10 pyridazin-3-yl H H 279.38 280.0 3.023 (2) 4-11 3-methoxy- H H 309.41 310.0 4.279 (2) pyrazm-2-yl 4-12 pyrazin-2-yl CH3, H 307.44 308.1 3.883 (2) 4-13 5-methyl-pyrazin- 2-yl H H 293.41 294.0 3.823 (2) No. R1 R2b R3 MW MH+ tR 4-14 6-methyl-pyrazin- H H 293.41 294.0 3.801 (2) 4-15 pyrimidin-2-yl H H 279.38 280.0 3.323 (2) 4-16 3-ethoxy-pyrazin- H H 323.44 323.9 4.861 (2) 4-17 6-propoxy- H H 337.46 337.9 5.300 (2) pyrazin-2-yl 4-18 pyrazin-2-yl H Cl 313.83 314.0 4.223 (2) 4-19 3-methoxy- H Cl 343.86 344.1 18.71 (3) pyrazm-2-yl 4-20 3-methoxy- CH3 Cl 357.88 358.1 19.66 (3) pyrazm-2-yl 4-21 pyridazin-3-yl H Cl 313.83 313.8 4.027 (2) 4-22 3-inethoxy- (S) -CH3 Cl 357.88 357.8 5.195 (2) pyrazin-2-yl profile 3 4-23 3-methoxy- profile Cl 357.88 357.8 5.177 (2) pyrazin-2-yl profile 4-24 pyrazin-2-yl H CH3 293.41 293.9 4.008 (2) 4-25 pyridazin-3-yl H CH3 293.41 294.1 3.862 (2) 4-26 pyrazin-2-yl CH3 CH3 307.44 307.9 4.366 (2) 4-27 3-methoxy- CH3 CH3 337.46 337.9 5.113 (2) pyrazin-2-yl 4-28 pyrazin-2-yl (R) -CH3 CH3 307.44 307.9 4.337 (2) profile 4 4-29 pyrazin-2-yl (S) -CH3 CH3 307.44 307.9 4.336 (2) profile 4 4-30 3-methoxy- (R) -CH3 CH3 337.46 337.9 5.087 (2) pyrazin-2-yl profile 4-31 3-methoxy- profile CH3 337.46 337.9 5.100 (2) pyrazin-2-yl profile 4-32 pyrazin-2-yl H F 297.38 297.9 3.706 (2) 4-33 pyridazin-3-yl H F 297.38 297.9 3.308 (2) 4-34 3-methoxy- H F 327.40 327.9 4.558 (2) pyrazin-2-yl 4-35 3-methoxy- Me F 341.43 341.9 4.833 (2) No. R1 RZb R3 MW MH+ tR (method) 4-36 3-methoxy- (R)-CH3 F 341.43 341.9 4.919 (2) pyrazin-2-yl profile 6 4-37 3-methoxy- (S)-CH3 F 341.43 341.8 4.878 (2) pyrazm-2-yl profile 6 4-38 3-ethoxy-pyrazin- Me F 355.45 356.1 5.212 (2) -Y 4-39 3-methoxy- Et 355.45 356.1 5.294 (2) pyrazm-2-yi 4-40 pyrazin-2-yl H OCH3 309.41 310.1 3.415 (2) 4-41 pyrazin-2-yl Me OCH3 323.44 323.9 3.947 (2) 4-42 pyridazin-3-yl H OCH3 309.41 309.9 3.253 (2) 4-43 3-methoxy- Me OCH3 353.46 353.9 4.565 (2) pyrazin-2-yl 4-44 3-methoxy- (S)-CH3 OCH3 353.46 354.1 4.563 (2) pyrazm-2-yl profile 7 4-45 3-methoxy- (R)-CH3 OCH3 353.46 354.1 4.533 (2) pyrazm-2-yl profile 7 4-46 pyrazin-2-yl (R) -CH3 OCH3 323.44 323.9 3.710 (2) profile 4-47 pyrazin-2-yl (S) -CH3 profile 7 OCH3 323.44 323.9 3.774 (2) profile 4-48 3-hydroxy- CH3 309.4 310.1 3.657(2) pyrazin-2-yl 4-49 3-hydroxy- (R)-CH3 F 327.4 328.0 3.941 (2) pyrazin-2-yl 4-50 3-ethoxy-pyrazin- (R)-CH3 F 355.45 356.1 5.261 (2) 2-yl profile 4 4-51 3-ethoxy-pyrazin- (S)-CH3 F 355.45 356.1 5.286 (2) 2-yl profile 4
  • 2
  • [ 13925-00-3 ]
  • [ 3409-21-0 ]
  • C19H25N3O [ No CAS ]
 

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