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Chemical Structure| 3413-28-3 Chemical Structure| 3413-28-3

Structure of 3413-28-3

Chemical Structure| 3413-28-3

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Product Details of [ 3413-28-3 ]

CAS No. :3413-28-3
Formula : C11H14FNO
M.W : 195.23
SMILES Code : FC1=CC=C(OC2CCNCC2)C=C1
MDL No. :MFCD04115015
InChI Key :QUPXFCLFBNUVGX-UHFFFAOYSA-N
Pubchem ID :3734896

Safety of [ 3413-28-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 3413-28-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3413-28-3 ]

[ 3413-28-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 22280-60-0 ]
  • [ 3413-28-3 ]
  • C17H18FN3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 40℃; for 16h; B1 in DMF (15 mL)(1.50 g, 7.68 mmol), 2-chloro-5-nitropyridine (1.33 g, 7.68 mmol), K2CO3 (3.18 g, 23.0 mmol) in a mixture of 40 16 hours It was stirred. After diluting the mixture with water (20 mL) and extracted with EtOAc (30 mL x2). The combined extracts are washed with brine (60 mL x 2), dried over anhydrous Na2SO4 and concentrated under reduced pressure, after creating the crude residue, the crude residue was silica gel column (PE / EtOAc = 10 / purification by 1) produced by the compound B2.
  • 2
  • [ 20426-80-6 ]
  • [ 3413-28-3 ]
  • 1-chroman-4-yl(4-(4-fluorophenoxy)pipendin-1-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20℃; for 2h; C. To a solution of <strong>[20426-80-6]chroman-4-carboxylic acid</strong> (100 mg, 0.56 mmol) and 4-(4- fluorophenoxy)piperidine (110 mg, 0.56 mmol) in DCM (10.0 mL) was added 1-(3- dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.11 g, 0.56 mmol), N- Hydroxybenzotrizole (0.08 g, 0.56 mmol) and triethylamine (0.11 g, 1.12 mmol). The reaction was stirred at ambient temperature for 2 h. Water (20 mL) was added and then extracted with DCM (3 X 30 mL). The combined organics were washed with brine, dried over Na2SO4. After filtered and concentrated, the residue was purified by silica column chromatography (EtOAc: hexanes = 1.5: 1) to give the desired product (100 mg, 0.28 mmol) as colorless oil.
 

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