[ CAS No. 3430-33-9 ] {[proInfo.proName]}

Name: 3430-33-9|2,6-Dimethylpyridin-3-amine|98%
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SKU: A160547
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2D 3D

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Quality Control of [ 3430-33-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 3430-33-9 ]

SDS Specification

Alternatived Products of [ 3430-33-9 ]

Product Details of [ 3430-33-9 ]

CAS No. :	3430-33-9	MDL No. :	MFCD01646409
Formula :	C₇H₁₀N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WISXXOGOMDYNSN-UHFFFAOYSA-N
M.W :	122.17	Pubchem ID :	76964
Synonyms :

Calculated chemistry of [ 3430-33-9 ]

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.29
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	38.57
TPSA :	38.91 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.36 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.41
Log Po/w (XLOGP3) :	0.97
Log Po/w (WLOGP) :	1.29
Log Po/w (MLOGP) :	0.49
Log Po/w (SILICOS-IT) :	1.54
Consensus Log Po/w :	1.14

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.7
Solubility :	2.43 mg/ml ; 0.0199 mol/l
Class :	Very soluble
Log S (Ali) :	-1.37
Solubility :	5.15 mg/ml ; 0.0422 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-2.39
Solubility :	0.493 mg/ml ; 0.00404 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.23

Safety of [ 3430-33-9 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 3430-33-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 3430-33-9 ]
Downstream synthetic route of [ 3430-33-9 ]

[ 3430-33-9 ] Synthesis Path-Upstream 1~10

1
[ 15513-52-7 ]
[ 3430-33-9 ]

Reference： [1] Applied Organometallic Chemistry, 2010, vol. 24, # 6, p. 477 - 480
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990, # 7, p. 2089 - 2097
[3] Chemische Berichte, 1939, vol. 72, p. 577,579
[4] Journal of the Chemical Society, 1950, p. 2952,2955
[5] Chemicke Listy, 1952, vol. 46, p. 551[6] Chem.Abstr., 1954, p. 2710
[7] Yakugaku Zasshi, 1941, vol. 61, p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94[8] Chem.Abstr., 1951, p. 2941
[9] Chemical Communications, 2011, vol. 47, # 39, p. 10972 - 10974
[10] Green Chemistry, 2015, vol. 17, # 2, p. 898 - 902
[11] Patent: WO2017/133657, 2017, A1, . Location in patent: Page/Page column 66
[12] Patent: WO2017/133667, 2017, A1, . Location in patent: Page/Page column 178

2
[ 1587660-46-5 ]
[ 3430-33-9 ]

Reference： [1] Journal of the American Chemical Society, 2014, vol. 136, # 14, p. 5279 - 5282

3
[ 76809-28-4 ]
[ 3430-33-9 ]
[ 69-72-7 ]

Reference： [1] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 10, p. 3020 - 3028

4
[ 4328-88-5 ]
[ 3430-33-9 ]

Reference： [1] Journal of the Chemical Society, 1925, vol. 127, p. 1502

5
[ 108-48-5 ]
[ 3430-33-9 ]

Reference： [1] Chemische Berichte, 1939, vol. 72, p. 577,579

6
[ 3430-33-9 ]
[ 1122-43-6 ]

Reference： [1] Chemische Berichte, 1939, vol. 72, p. 577,579
[2] Yakugaku Zasshi, 1941, vol. 61, p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94[3] Chem.Abstr., 1951, p. 2941
[4] Chemische Berichte, 1939, vol. 72, p. 577,579
[5] Yakugaku Zasshi, 1941, vol. 61, p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94[6] Chem.Abstr., 1951, p. 2941

7
[ 3430-33-9 ]
[ 4943-67-3 ]

Reference： [1] Journal of the Chemical Society, 1950, p. 2952,2955

8
[ 3430-33-9 ]
[ 3430-34-0 ]

Reference： [1] Patent: CN107311919, 2017, A,

9
[ 16013-85-7 ]
[ 762-04-9 ]
[ 32263-14-2 ]
[ 3430-33-9 ]
[ 62476-56-6 ]

Reference： [1] Patent: US6303784, 2001, B1,

10
[ 3430-33-9 ]
[ 52090-69-4 ]

Reference： [1] Patent: WO2012/87782, 2012, A1,
[2] Patent: WO2017/133657, 2017, A1,
[3] Patent: WO2017/133667, 2017, A1,

[ 3430-33-9 ] Synthesis Path-Downstream 1~88

1
[ 15513-52-7 ]
[ 3430-33-9 ]

Yield	Reaction Conditions	Operation in experiment
	With palladium on activated charcoal; hydrogen; In methanol; at 150℃; under 760.051 Torr; for 3h;	[A] 2 6-Dimethyipyridin-3-amine[0292][0293]To a solution of 2 6-dimethyl-3-nitropyridine (20g 130 mmol) in MeOH (100 mL) was added Pd/C (2 g) and the reaction mixture was stirred at 150 under H2atomsphere (1 atm) for 3 h. Afterwards the mixture was filtered and the filtrate was concentrated in vacuo to give a crude title compound (14.7 g 91.8yield) as an oil. It was used directly in the next step without further purification.

Reference： [1]Applied Organometallic Chemistry,2010,vol. 24,p. 477 - 480
[2]Journal of the Chemical Society. Perkin transactions I,1990,p. 2089 - 2097
[3]Chemische Berichte,1939,vol. 72,p. 577,579
[4]Journal of the Chemical Society,1950,p. 2952,2955
[5]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1941,vol. 61,p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr.,1951,p. 2941
[6]Chemical Communications,2011,vol. 47,p. 10972 - 10974
[7]Green Chemistry,2015,vol. 17,p. 898 - 902
[8]Patent: WO2017/133657,2017,A1 .Location in patent: Page/Page column 66
[9]Patent: WO2017/133667,2017,A1 .Location in patent: Page/Page column 178

2
[ 64-18-6 ]
[ 3430-33-9 ]
[ 54173-21-6 ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

3
[ 3430-33-9 ]
[ 108-24-7 ]
[ 51468-08-7 ]

Yield	Reaction Conditions	Operation in experiment
	With triethylamine; In dichloromethane; for 2h;	To a solution of J-1 (5.00 g, 40.9 mmol) in DCM (25 mL) is added acetic anhydride (5.00 mL, 51.8 mmol) followed by triethylamine (6.50 mL, 46.7 mmol). After 2 hours, the mixture is concentrated and diluted with water, made basic with sodium carbonate, and extracted with EtOAc (8 x 30 mL). The combined organic layers are dried over magnesium sulfate, filtered and concentrated to provide J-2.
	With triethylamine; In dichloromethane; at 20℃; for 12h;	[B] N- (2 6-Dimethylpyridin-3-yl) acetamide[0295][0296]To a solution of 2 6-dimethylpyridin-3-amine (14.7 g 0.12mol) Et3N (13.3 g 0.13 mol) in DCM (140 mL) was addedAc2O (36.8 g 0.36mol) and the resulting mixture solution was stirred at room temperature for 12 h. Afterwards the reaction mixture was concentrated under reduced pressure and the residule was diluted with water basified with aq. NaHCO3solution (10 mL) and extracted with EtOAc (10 mL x 3) . The combined organic layers were dried over anhy. Na2SO4 filtered and concentrated in vacuo to give a crude title compound acetamide (12 g 60.9yield) as a white solid. MS 165.20 [M+H]+
	Reflux;	To <strong>[3430-33-9]2,6-dimethyl-3-aminopyridine</strong> as raw material, will0.1 mol of <strong>[3430-33-9]2,6-dimethyl-3-aminopyridine</strong> and 0.13 mol of acetic anhydride were added to 250 mlFour-necked flask, the oil bath was warmed to reflux, the reaction was followed by thin-layer chromatography,When the reaction solution was cooled to below 23 C, 0.11 mol of liquid bromine was slowly added dropwise,After the addition was completed, the reaction was carried out at 40 C for 3 hours, and then water was added to the system to all the solidsAfter dissolving, 40 ml of 35% sodium hydroxide solution was slowly added dropwise,End of the reaction was continued for 20 minutes, suction filtration, drying, recrystallization obtained2,6-dimethyl-3-amino-5-bromopyridine. The solvent used for the recrystallization was methanol with a molar yield of 65%.

at 23 - 48℃; for 2.5h;Reflux;

In order to 2, 6 - dimethyl -3 - aminopyridine as raw materials, the 2, 6 - dimethyl -3 - aminopyridine 0.1 muM and acetic anhydride 0.16 muM added to the 250 ml four flasks, oil bath heated to reflux, thin layer chromatography for the tracking reaction, reacting liquid cooling to 23 C below, slow [...] 0.11 muM, after adding, 48 C reaction 2.5 hours, then water is added to the system to all the solid dissolved, slowly dropping 40 ml35% of sodium hydroxide solution, after adding continue to reaction 30 minutes, filtering, drying, by recrystallization to obtain 2, 6 - dimethyl -3 - amino -5 bromo pyridine, the recrystallization solvent used is methanol, the molar yield is 72%.

Reference： [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1941,vol. 61,p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr.,1951,p. 2941
[2]Patent: WO2012/87782,2012,A1 .Location in patent: Page/Page column 57
[3]Patent: WO2017/133657,2017,A1 .Location in patent: Page/Page column 66; 67
[4]Patent: CN107311919,2017,A .Location in patent: Paragraph 0019; 0022; 0025
[5]Patent: WO2017/133667,2017,A1 .Location in patent: Page/Page column 178
[6]Patent: CN109748853,2019,A .Location in patent: Paragraph 0019; 0022; 0024; 0025

4
[ 3430-33-9 ]
[ 141-97-9 ]
N-(2,6-dimethyl-[3]pyridyl)-acetoacetamide [ No CAS ]

Reference： [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1941,vol. 61,p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr.,1951,p. 2941

5
[ 3430-33-9 ]
[ 98-88-4 ]
N-(2,6-dimethyl-[3]pyridyl)-benzamide [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

6
[ 3430-33-9 ]
[ 75-36-5 ]
[ 51468-08-7 ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

7
[ 3430-33-9 ]
[ 102-92-1 ]
N-(2,6-dimethyl-[3]pyridyl)-trans-cinnamamide [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

8
[ 3430-33-9 ]
[ 645-45-4 ]
3-phenyl-propionic acid-(2,6-dimethyl-[3]pyridylamide) [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

9
[ 3430-33-9 ]
[ 121-60-8 ]
[ 855932-44-4 ]

Reference： [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1941,vol. 61,p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr.,1951,p. 2941
[2]Roczniki Chemii,1947,vol. 21,p. 55,57
Chem.Abstr.,1948,p. 1907

10
[ 3430-33-9 ]
[ 29976-16-7 ]

Reference： [1]Roczniki Chemii,1951,vol. 25,p. 251
Chem.Abstr.,1952,p. 6127

11
[ 3430-33-9 ]
[ 1122-43-6 ]

Reference： [1]Chemische Berichte,1939,vol. 72,p. 577,579
[2]Chemische Berichte,1939,vol. 72,p. 577,579

12
[ 3430-33-9 ]
[ 130562-20-8 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1990,p. 2089 - 2097

13
[ 3430-33-9 ]
[ 106576-55-0 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 5603 - 5605
[2]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 4101 - 4109

14
[ 76809-28-4 ]
[ 3430-33-9 ]
[ 69-72-7 ]

Reference： [1]Chemical and pharmaceutical bulletin,1980,vol. 28,p. 3020 - 3028

16
[ 3430-33-9 ]
[ 1620-98-0 ]
2,6-di-tert-butyl-4-[(2,6-dimethyl-pyridin-3-ylimino)-methyl]-phenol [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 4827 - 4845

17
[ 24525-01-7 ]
[ 3430-33-9 ]
C₂₁H₂₁N₃SO₂ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2007,vol. 17,p. 1193 - 1196

18
[ 3430-33-9 ]
2,6-di-tert-butyl-4-[(2,6-dimethyl-pyridin-3-ylamino)-methyl]-phenol [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 4827 - 4845

19
[ 3430-33-9 ]
N-(3,5-di-tert-butyl-4-hydroxy-benzyl)-N-(2,6-dimethyl-pyridin-3-yl)-4-methyl-benzenesulfonamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2003,vol. 11,p. 4827 - 4845

20
[ 3430-33-9 ]
[ 106576-57-2 ]

Reference： [1]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 4101 - 4109
[2]Chemical and Pharmaceutical Bulletin,1985,vol. 33,p. 5603 - 5605

21
[ 3430-33-9 ]
[ 114627-76-8 ]

Reference： [1]Chemical and pharmaceutical bulletin,1987,vol. 35,p. 4101 - 4109

22
[ 3430-33-9 ]
[ 130562-27-5 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1990,p. 2089 - 2097

23
[ 3430-33-9 ]
[ 130562-27-5 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1990,p. 2089 - 2097

24
[ 3430-33-9 ]
[ 42753-74-2 ]

Reference： [1]Roczniki Chemii,1947,vol. 21,p. 55,57
Chem.Abstr.,1948,p. 1907
[2]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1941,vol. 61,p. 230,232; dtsch. Ref. Nr. 6, S. 91, 94
Chem.Abstr.,1951,p. 2941

25
[ 108-48-5 ]
[ 3430-33-9 ]

Reference： [1]Chemische Berichte,1939,vol. 72,p. 577,579

26
[ 3430-33-9 ]
3-iodo-pyridine-2,6-dicarboxylic acid [ No CAS ]

Reference： [1]Roczniki Chemii,1951,vol. 25,p. 251
Chem.Abstr.,1952,p. 6127

27
[ 3430-33-9 ]
[ 4943-67-3 ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

28
[ 3430-33-9 ]
[ 854018-76-1 ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

29
[ 3430-33-9 ]
5-methyl-2-trans(?)-styryl-1H-pyrrolo[3,2-b]pyridine [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

30
[ 3430-33-9 ]
2,5-dimethyl-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

31
[ 3430-33-9 ]
[ 860362-36-3 ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

32
[ 3430-33-9 ]
3-benzyl-2,5-dimethyl-1H-pyrrolo[3,2-b]pyridine [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

33
[ 3430-33-9 ]
5-methyl-2-trans(?)-styryl-1H-pyrrolo[3,2-b]pyridine-4-oxide [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

34
[ 3430-33-9 ]
2,5-dimethyl-3-phenylazo-1H-pyrrolo[3,2-b]pyridine [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

35
[ 3430-33-9 ]
3-bromo-2,5-dimethyl-1H-pyrrolo[3,2-b]pyridine [ No CAS ]

Reference： [1]Journal of the Chemical Society,1950,p. 2952,2955

36
[ 3430-33-9 ]
[ 87-13-8 ]
[ 5671-69-2 ]

Yield	Reaction Conditions	Operation in experiment
84%	at 110℃; for 3h;	3-Amino-2,6-dimethylpyridine (0.5 g, 4.09 mmol) and 2-ethoxymethylene-malonic acid dimethyl ester (0.886 g, 4.09 mmol) were placed in a round bottom flask and this mixture was heated at 110 C. under a nitrogen atmosphere for 3 h. The reaction was then cooled to RT and petroleum ether was then added. The suspension was filtered and the collected precipitate was maintained under vacuum overnight to provide the product as a light yellow solid (84%). 1H NMR (CDCl3, 400 MHz) delta 11.10-11.07 (d, J=13.2 Hz, 1H), 8.44-8.40 (m, 1H), 7.41-7.39 (m, 1H), 7.06-7.04 (m, 1H), 4.33 (q, J=7.2 Hz, 2H), 4.25 (q, J=7.2 Hz, 2H), 2.59 (s, 3H), 2.52 (s, 3H), 1.38 (t, J=7.1 Hz, 3H), 1.33 (t, J=7.1 Hz, 3H). m/z (ES-MS) 293 (M+, 60%)

Reference： [1]Patent: US2006/135551,2006,A1 .Location in patent: Page/Page column 47

37
[ 897732-25-1 ]
[ 3430-33-9 ]
4-[6-(2,6-dimethyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
> 15%		A mixture of 4-(6-chloro-5-methoxy-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid isopropyl ester (1.52 g, 4.60 mmol), <strong>[3430-33-9]2,6-dimethylpyridin-3-amine</strong> (0.562 g, 4.60 mmol), palladium acetate (0.0584 g, 0.260 mmol), and sodium 2-methylpropan-2-olate (0.663 g, 6.90 mmol) in 50 mL dioxane was stirred under reflux for 18 h. Mixture was concentrated and extracted with brine and CH2Cl2. Organic phases were dried over MgSO4, filtered, and concentrated. Residue was purified by column chromatography (AcOEt/hexane 5:1?AcOEt?AcOEt/MeOH 10:1). Fractions containing pure product were concentrated, residue was treated with 4M HCl in dioxane, and concentrated to give 4-[6-(2,6-dimethyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester as a white (0.285 g, 15%). Fractions containing product contaminated with <strong>[3430-33-9]2,6-dimethylpyridin-3-amine</strong> was concentrated to give 0.30 g of ca 80% pure product. 1HNMR (CDCl3, 400 MHz) delta 1.24-1.25 (d, J=6.2 Hz, 6H), 1.78-1.84 (m, 2H), 2.00-2.05 (m, 2H), 2.52 (2s, 6H), 3.37-3.44 (m, 2H), 3.76-3.81 (m, 2H), 4.03 (s, 3H), 4.91-4.97 (m, 1H), 5.33-5.38 (m, 1H), 6.81 (s, 1H), 7.04-7.06 (d, J=8.2 Hz, 1H), 8.09 (s, 1H), 8.11-8.13 (d, J=8.2 Hz, 1H). Exact mass calculated for C21H29N5O4 415.22, found 416.5 (MH+).

Reference： [1]Patent: US2006/155128,2006,A1 .Location in patent: Page/Page column 56

38
[ 3430-33-9 ]
[ 87-13-8 ]
[ 5671-80-7 ]

Yield	Reaction Conditions	Operation in experiment
0.5 g (30%)	In diphenylether; 5,5-dimethyl-1,3-cyclohexadiene;	Preparation 47 Ethyl 4-Hydroxy-6,8-dimethyl-1,7-naphthyridine-3-carboxylate [BV.3] A mixture of <strong>[3430-33-9]2,6-dimethyl-3-aminopyridine</strong> (0.85 g) and diethyl ethoxymethylene-malonate (1.53 g) is heated at 135 C. in xylene (30 mL) for 2 h allowing for removal of ethanol. After the solvent is removed, the mixture is suspended in diphenyl ether (15 mL). The mixture is then heated to reflux with removal of ethanol for 30 min. The reaction mixture is cooled to room temperature and hexanes (20 mL) is added. The resulting precipitate is filtered, washed with diethyl ether (2*10 mL) and dried to give 0.5 g (30%) of the title compound as a brown solid. Physical chracteristics: MS (ESI+) m/z 247 (M+H)+; 1H NMR (DMSO) delta 8.67, 7.97,4.38, 2.85,2.67, 1.40.

Reference： [1]Patent: US2002/25960,2002,A1

39
[ 264608-32-4 ]
[ 3430-33-9 ]
(2R,3R,4S,5R)-2-{2-[(2,6-Dimethyl-3-pyridinyl)amino]methyl}-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium acetate; triethylamine; In water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;	Example 49 (2R,3R,4S,5R)-2-{2-[(2,6-Dimethyl-3-pyridinyl)amino]methyl}-6-[(2,2-diphenylethyl)amino]-9H-purin-9-yl}-5-(methoxymethyl)tetrahydro-3,4-furandiol {9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}methyl methanesulfonate (preparation 25) (75 mg, 0.13 mmol) was added to a solution of 2,6dimethyl-3-pyridinylamine (22 mg, 0.17 mmol) and triethylamine (0.036 ml, 0.26 mmol) in ethyl acetate (3 ml) and N,N-dimethylformamide (1 ml) in the reaction vessel of a Argonaut Quest 210 machine. The reaction mixture was agitated and heated to 60 C. for 12 hr. More <strong>[3430-33-9]2,6-dimethyl-3-pyridinylamine</strong> (22 mg, 0.17 mmol) and triethylamine (0.036 ml, 0.26 mmol) were added and heating and agitation continued for a further 24 hr. The reaction mixture was then washed with water and the organic phase separated and dried with anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give a residue which was purified by reverse phase HPLC using firstly a Lana C8 (2) column and then a Magellan C18 column eluding with 5 mM ammonium acetate in water:2 mM ammonium acetate in acetonitrile (90:10) decreasing in polarity to 5 mM ammonium acetate in water:2 mM ammonium acetate in acetonitrile (10:90) as eluant. This gave the title compound (9 mg) as a gum. MS: 596 (MH+). 1H NMR (CDCl3) delta=7.95 (1H, s), 7.35-7.20 (10H, m), 6.85-6.70 (2H, m), 6.10-6.00 (1H, m), 5.95-5.90 (1H, m), 4.45-4.40 (1H, m), 4.40-4.25 (7H, m), 3.70-3.50 (2H, m), 3.35 (3H, s), 2.40-2.30 (6H, m).

Reference： [1]Patent: US6326359,2001,B1

40
[ 16013-85-7 ]
[ 762-04-9 ]
[ 32263-14-2 ]
[ 3430-33-9 ]
[ 62476-56-6 ]

Yield	Reaction Conditions	Operation in experiment
	With iron;toluene-4-sulfonic acid; In acetic acid; toluene;	Example 14 Diethyl alpha-(4-hydroxy-3-methoxy-5-methylphenyl)-N-[3-(2,6-dichloropyridyl)]-amino-methylphosphonate 3-Amino-2,6-dichloropyridine (mp=118-120° C.) was obtained in quantitative yield by reacting 3-nitro-2,6-dichloropyridine with a mixture of reduced iron in aqueous acetic acid. A mixture of 1.66 g (10 mmol) of 4-hydroxy-3-methoxy-5-methyl-benzaldehyde and 1.63 g (10 mmol) of 3-amino-2,6-dimethylpyridine dissolved in 40 ml toluene and a catalytic amount of p-toluenesulfonic acid (ca. 1 mg) contained in a flask connected to a Dean Stark apparatus was refluxed for 16 h. Diethyl phosphite (3.45 g, 25 mmol) was added to toluene solution of the crude imine and the mixture was refluxed for 7 h.

Reference： [1]Patent: US6303784,2001,B1

41
[ 690635-43-9 ]
[ 3430-33-9 ]
2-bromo-4-[(2,6-dimethylpiperidin-3-yl)amino]thieno[3,2-c]pyridine-7-carbonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 80℃; for 12h;	2-bromo-4- [(2,6-dimethylpiperidin-3-yl)amino1 thieno [3,2-cl pyridine-7-carbonitrile; To 2,6-dimethylpiperidin-3-amine (1.23 g, 4.50 mmol) dissolved in NMP (10 mL) is added potassium carbonate (1.87 g, 13.5 mmol) and 2-bromo-4-chlorothieno[3,2-c]pyridine-7- carbonitrile (1.23 g, 4.50 mmol). The resulting mixture is heated to 80 0C and stirred for twelve hours or until LCMS indicates complete conversion to product. The mixture is then diluted with water (100 mL) and the resulting solid is filtered, washed with water (20 mL) and dried under reduced pressure for up to eight hours. LCMS (ES, M+H=366).

Reference： [1]Patent: WO2006/106326,2006,A1 .Location in patent: Page/Page column 82

42
[ 3430-33-9 ]
[ 912368-93-5 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; hydrogen;platinum(IV) oxide; In water; under 2585.81 Torr; for 48h;	Example 83; 4-[(2,6-dimethylpiperidin-3-yl)aminol-2-phenylthieno[3,2-clpyridine-7-carboxamide; 2,6-dimethylpiperidin-3-amine; To a high-pressure vessel containing 2,6-dimethylpyridin- 3-amine (2.08 g, 17.0 mmol) is added water and 12 N HCl (10 niL each) followed by platinum (IV) oxide (500 mg, 2.20 mmol) under nitrogen. The high-pressure vessel is then evacuated under reduced pressure and placed on a Parr hydrogenation apparatus at 50 psi for 48 hours. The mixture is evacuated under nitrogen, filtered over a bed of diatomaceous earth, and rinsed with copious amounts of MeOH. The collected filtrate is concentrated in vacuo to afford the title compound that is used directly in the next reaction as a mixture of isomers. LCMS (ES, M+H-129).

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073
[2]Patent: WO2006/106326,2006,A1 .Location in patent: Page/Page column 82

43
[ 3430-33-9 ]
[ 79-04-9 ]
N-(2,6-dimethyl-pyridin-3-yl)-α-chloroacetamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With pyridine;	EXAMPLE 13 Preparation of N-(2,6-Dimethyl-3-pyridyl)-alpha-chloroacetamide A solution of <strong>[3430-33-9]2,6-dimethyl-3-aminopyridine</strong> (24.9 grams) in ether (200 ml), and pyridine (21 grams) are charged into a glass reaction vessel equipped with mechanical stirrer, thermometer and addition funnel. The reaction mixture is cooled to a temperature below about 10 C and chloroacetyl chloride (11.3 grams) is slowly added over a period of about 15 minutes. Stirring and cooling is continued for an additional period of about 1 hour to ensure the completion of the reaction. The resulting precipitate is then recovered by filtration, is washed with aqueous potassium carbonate and with water, and is dried to yield the desired product N-(2,6-dimethyl-3-pyridyl)-alpha-chloroacetamide.

Reference： [1]Patent: US3996352,1976,A

44
2-(3,4-dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester [ No CAS ]
[ 3430-33-9 ]
3-(3,4-dimethyl-benzoyl)-6,8-dimethyl-1H-[1,7]naphthyridin-4-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In diphenylether; at 20 - 250℃; for 4h;	0.50 g (2.01 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-methoxy-acrylic acid methyl ester and 0.25 g (2.01 mmol) of 2,6-Dimethyl-pyridin-3-ylamine were heated at 100 0C for two hours. After cooling to room temperature 30 mL of diphenyl ether was added and heated at 250 0C for two hours. The reaction was allowed to cool to room temperature and hexane was added. The brown precipitate was collected by filtration to yield 45 mg of 3 -(3,4- Dimethyl-benzoyl)-6,8-ditaunethyl- IH-[1 ,7]naphthyridin-4-one.

Reference： [1]Patent: WO2007/59108,2007,A2 .Location in patent: Page/Page column 90

45
[ 892403-44-0 ]
[ 3430-33-9 ]
[ 1256374-45-4 ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

46
[ 892403-44-0 ]
[ 3430-33-9 ]
[ 1256374-46-5 ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

47
[ 3430-33-9 ]
[ 1256374-45-4 ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

48
[ 3430-33-9 ]
[ 1256374-46-5 ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

49
[ 3430-33-9 ]
C₁₉H₂₃N₃O₃ [ No CAS ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

50
[ 3430-33-9 ]
[ 30924-93-7 ]
C₂₄H₃₁N₃O₅ [ No CAS ]

Reference： [1]Bioconjugate Chemistry,2010,vol. 21,p. 2038 - 2048

51
[ 3430-33-9 ]
[ 1383735-50-9 ]
[ 1383735-51-0 ]

Reference： [1]Patent: WO2012/87782,2012,A1

52
[ 3430-33-9 ]
[ 1383735-35-0 ]

Reference： [1]Patent: WO2012/87782,2012,A1

53
[ 3430-33-9 ]
[ 1383735-37-2 ]

Reference： [1]Patent: WO2012/87782,2012,A1

54
[ 3430-33-9 ]
[ 1383735-38-3 ]

Reference： [1]Patent: WO2012/87782,2012,A1

55
[ 3430-33-9 ]
[ 1383733-72-9 ]

Reference： [1]Patent: WO2012/87782,2012,A1

56
[ 3430-33-9 ]
[ 52090-63-8 ]

Reference： [1]Patent: WO2012/87782,2012,A1

57
[ 3430-33-9 ]
[ 52090-69-4 ]

Reference： [1]Patent: WO2012/87782,2012,A1
[2]Patent: WO2017/133657,2017,A1
[3]Patent: WO2017/133667,2017,A1

58
[ 3430-33-9 ]
[ 1383734-99-3 ]

Reference： [1]Patent: WO2012/87782,2012,A1

59
[ 3430-33-9 ]
[ 1383735-49-6 ]

Reference： [1]Patent: WO2012/87782,2012,A1

60
[ 3430-33-9 ]
[ 1383735-03-2 ]

Reference： [1]Patent: WO2012/87782,2012,A1

61
[ 3430-33-9 ]
[ 1383735-59-8 ]

Reference： [1]Patent: WO2012/87782,2012,A1

62
[ 1587660-46-5 ]
[ 3430-33-9 ]

Reference： [1]Journal of the American Chemical Society,2014,vol. 136,p. 5279 - 5282

63
[ 85-44-9 ]
[ 3430-33-9 ]
[ 1592630-16-4 ]

Reference： [1]Chemical Communications,2014,vol. 50,p. 9273 - 9276

64
[ 108-77-0 ]
[ 3430-33-9 ]
4,6-dichloro-N-(2,6-dimethylpyridin-3-yl)-1,3,5-triazin-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20℃; for 36h;	General procedure: To a homogenous solution of S7 (20 mmol) in dioxane (60 mL) was added DIPEA (21 mmol) and S25/S26 (21mmol) and allowed to stir at room temperature for 36 h. Solvents were evaporated and water was added, extracted with EtOAc (3 x 100 mL), organic layers were washed with NaHCO3, brine and water, dried and evaporated to get white powder.

Reference： [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 5241 - 5248

65
[ 3430-33-9 ]
4-((4-chloro-6-((2,6-dimethylpyridin-3-yl)amino)-1,3,5-triazin-2-yl)amino)benzonitrile [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry,2014,vol. 22,p. 5241 - 5248

66
[ 3430-33-9 ]
C₁₇H₁₃ClN₄O₃ [ No CAS ]
[ 76-05-1 ]
3-(4-(3-(2-chlorophenyl)ureido)-1H-pyrazol-1-yl)-N-(2,6-dimethylpyridin-3-yl)benzamide triflluoroacetate salt [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2014,vol. 57,p. 10013 - 10030

67
[ 3430-33-9 ]
4-chloro-7-nitroisobenzofuran-1,3-dione [ No CAS ]
C₁₅H₁₀ClN₃O₄ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 3098 - 3111

68
[ 3430-33-9 ]
5-{(benzyloxy)methyl}isoxazol-3-carboxylic acid [ No CAS ]
N-(2,6-dimethylpyridin-3-yl)-5-benzyloxymethylisoxazole-3-carboxyamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
0.15 g	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20℃; for 3h;	5-benzyloxy-methyl - isoxazole-3-carboxylic acid (0.24g, 1.0mmol), 3- amino-2,6-dimethyl-pyridine (0.15g, 1.2mmol), 1- hydroxybenzotriazole (0. 01g, 0.1mmol) was added to the chloroform (amylene addition of goods) (2.5mL). To the mixture, it was added at room temperature 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.24 g, 1.2 mmol), and stirred at room temperature for 3 hours. Then, water was added to the reaction mixture, and the mixture was extracted twice with chloroform. After removing impurities through the organic layer to a short column which was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, represented by the following formula N-(2,6-dimethyl-3-yl) -5-benzyloxymethyl - isoxazole-3-carboxamide (hereinafter, the present invention compound (27 ) and referred to.) was obtained 0.15g.

Reference： [1]Patent: JP2016/30727,2016,A .Location in patent: Paragraph 0173

69
[ 3430-33-9 ]
tert-butyl 4-(10-bromo-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate [ No CAS ]
tert-butyl 4-{10-[(2,6-dimethylpyridin-3-yl)amino]-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl}piperidine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With potassium phosphate; t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2?,4?,6?-triisopropyl-1,1?-biphenyl)-2-(2?-amino-1,1?-biphenyl)]palladium(II) methanesulfonate; In tert-butyl alcohol; at 95℃; for 16h;Inert atmosphere;	Under argon, tert-butyl 4-(10-bromo-2-oxo-l,2-dihydropyrimido[l,2-b]indazol-4-yl)piperidine-l- carboxylate (150 mg, 335 muiotaetaomicron), <strong>[3430-33-9]2,6-dimethylpyridin-3-amine</strong> (102 mg, 838 muiotaetaomicron), Tripotassium phosphate (99.6 mg, 469 muiotaetaomicron), tBuBrettPhos (9.75 mg, 20.1 muiotaetaomicron), and tBuBrettPhos Pd G3 (17.2 mg, 20.1 muiotaetaomicron) were dissolved in tert-Butanol (3.0 ml, 31 mmol). The mixture was stirred at 95 C for 16 h and then purified via reverse phase chromatography (Method: Reprosil C18; 10 muiotaeta; 125x30 mm / flow: 45 ml/min / solvents: A = water (0,01% formic acid), B = Acetonitrile / gradient 0.00-4.25 min = 10%B, 4.50min = 20%B, 15.50min = 85%B, 16.00-18.50min = 100%B, 18.75.00-22.00min = 20%B) which afforded the product after drying in vacuo. The obtained amout was 85 mg (60 % purity, 31 % of theory). LC-MS (Method 1): Rt = 0.79 min; MS (ESIpos): m/z = 489 [M+H]+

Reference： [1]Patent: WO2016/173948,2016,A1 .Location in patent: Page/Page column 130; 131

70
[ 3430-33-9 ]
tert-butyl 4-(10-bromo-2-oxo-1,2-dihydropyrimido[1,2-b]indazol-4-yl)piperidine-1-carboxylate [ No CAS ]
10-[(2,6-dimethylpyridin-3-yl)amino]-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b]indazol-2-one hydrochloride [ No CAS ]

Reference： [1]Patent: WO2016/173948,2016,A1

71
[ 3430-33-9 ]
2,6-dimethylpyridine-3-sulfonyl chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
30%		Thionylchloride (2mL)wasaddedtowater (5mL)dropwise.Theresultedmixturewasstirredatroomtemperatureforovernight,andthenCuCl (1.1g,8.2mmol)wasaddedtoabovemixtureunderice- bathtoformaCuClsolution.Toanice- coolingsolutionof2,6-dimethylpyridin-3- amine (1.0g,8.2mmol)inamixedsolventofhydrochloricacid (1mL,37,v/v)andwater (10mL)wasaddedasolutionofaqueousNaNO2(5mL,0.82mol),theresultedmixturewasstirredfor0.5h,andthentheCuClsolutionpreparedbeforewasadded.Theresultedmixturewasstirredfor1h,andextractedwithDCM(3×20mL).Thecombinedorganiclayerwaswashedwithbrine(25mL)anddriedoveranhydrousNa2SO4,filteredandconcentratedtoafford2,6- dimethylpyridine-3-sulfonylchloride (500mg,yield:30)asayellowoil.m/z:[M+H]+187

Reference： [1]Patent: WO2016/173493,2016,A1 .Location in patent: Page/Page column 30

72
[ 3430-33-9 ]
2,6-dimethylpyridine-3-sulfonamide [ No CAS ]

Reference： [1]Patent: WO2016/173493,2016,A1

73
[ 50-00-0 ]
[ 3430-33-9 ]
[ 123-08-0 ]
C₁₆H₁₆N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
86%		0.2 mol of <strong>[3430-33-9]2,6-dimethyl-3-aminopyridine</strong>, 0.46 mol of formaldehyde and 40 mL of chloroform were added to the reaction mixture, Should be 2h; then add 0.2mol of p-hydroxybenzaldehyde, heated to 80 C, the reaction 7h, with 0.5mol / L aqueous solution of sodium hydroxide Washed 1 times and then washed with deionized water 1 times, spin evaporation to remove the solvent, dry, yield 86%.

Reference： [1]Patent: CN103694232,2016,B .Location in patent: Paragraph 0058; 0059

74
[ 3430-33-9 ]
(rac)-tert-butyl ((1R,3S)-3-((5-fluoro-2-(5-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)pyrimidin-4-yl)amino)cyclohexyl)carbamate [ No CAS ]

Reference： [1]Patent: WO2017/133657,2017,A1

75
[ 3430-33-9 ]
(rac)-(1S,3R)-N₁-(5-fluoro-2-(5-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)pyrimidin-4-yl)cyclohexane-1,3-diamine [ No CAS ]

Reference： [1]Patent: WO2017/133657,2017,A1

76
[ 3430-33-9 ]
(rac)-N-((1R,3S)-3-((5-fluoro-2-(5-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)pyrimidin-4-yl)amino)cyclohexyl)picolinamide [ No CAS ]

Reference： [1]Patent: WO2017/133657,2017,A1

77
[ 3430-33-9 ]
(rac)-N-((1R,3S)-3-((5-fluoro-2-(5-methyl-1H-pyrazolo[4,3-b]pyridin-1-yl)pyrimidin-4-yl)amino)cyclohexyl)morpholine-4-carboxamide [ No CAS ]

Reference： [1]Patent: WO2017/133657,2017,A1

78
[ 729-44-2 ]
[ 3430-33-9 ]
2,6-dimethyl-3-(3,5-diphenyl-4H-1,2,4-triazol-4-yl)pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
45%	In N,N-dimethyl-aniline; at 180℃; for 20h;Inert atmosphere;	Step 2: Synthesis of 2,6-dimethyl-3-(3,5-diphenyl-4H-1,2,4-triazol-4-yl)pyridine (Abbreviation: Htaz-dmpy) Into a 300 mL three-neck flask were put 12.5 g (42.8 mmol) of bis(N-chlorophenylmethylidene)hydrazine synthesized in Step 1, 25 g (206 mmol) of <strong>[3430-33-9]3-amino-2,4-dimethylpyridine</strong>, and 100 mL of N,N-dimethylaniline, and the mixture was stirred under a nitrogen stream at 180 C. for 20 hours to be reacted. After the reaction, 1M hydrochloric acid was added to the reacted solution to neutralize the mixed solution. An organic layer was extracted from the neutralized solution with the use of ethyl acetate. This organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate, water, and saturated saline in this order. Anhydrous magnesium sulfate was added to the washed organic layer for drying, and the resulting mixture was subjected to gravity filtration to give a filtrate. Ethyl acetate of this filtrate was distilled off, and then purification was performed by silica column chromatography. As a developing solvent, ethyl acetate and toluene were used. The solvent of the resulting fraction was distilled off and recrystallization was performed, so that 6.3 g (19 mmol) of a white solid was obtained in a yield of 45%. The obtained white solid was identified as Htaz-dmpy by nuclear magnetic resonance (NMR). A synthesis scheme of Step 2 is shown in (a-2) below.

Reference： [1]Patent: US2017/271600,2017,A1 .Location in patent: Paragraph 0265

79
[ 3430-33-9 ]
N-(2-methylphenyl)chloromethylidene-N'-phenylchloromethylidenehydrazine [ No CAS ]
2,6-dimethyl-3-[3-(2-methylphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]pyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
13%	In N,N-dimethyl-aniline; at 180℃; for 35h;Inert atmosphere;	Step 1: Synthesis of 2,6-dimethyl-3-[3-(2-methylphenyl)-5-phenyl-4H-1,2,4-triazol-4-yl]pyridine (Abbreviation: Hinpptz-dmpy) Into a 300 mL three-neck flask were put 10 g (34.2 mmol) of N-(chlorophenylmethylene)-2-methyl-benzenecarbohydrazoylchloride, 20 g (163.7 mmol) of <strong>[3430-33-9]3-amino-2,4-dimethylpyridine</strong>, and 100 mL of N,N-dimethylaniline, and the mixture was stirred at 180 C. under a nitrogen stream for 35 hours to be reacted. After the reaction, 1M hydrochloric acid was added to the reacted solution to neutralize the mixed solution. An organic layer was extracted from the neutralized solution with the use of ethyl acetate. This organic layer was washed with a saturated aqueous solution of sodium hydrogen carbonate, water, and saturated saline in this order. Anhydrous magnesium sulfate was added to the washed organic layer for drying, and the resulting mixture was subjected to gravity filtration to give a filtrate. Ethyl acetate of this filtrate was distilled off, and then purification was performed by silica column chromatography. As a developing solvent, ethyl acetate and hexane were used. The solvent of the resulting fraction was distilled off and recrystallization was performed, so that 1.5 g (4.4 mmol) of a white solid was obtained in a yield of 13%. The obtained white solid was identified as Hmpptz-dmpy by nuclear magnetic resonance (NMR). A synthesis scheme of Step 1 is shown in (a-1) below.

Reference： [1]Patent: US2017/271600,2017,A1 .Location in patent: Paragraph 0250

80
[ 3430-33-9 ]
N-(2-methylphenyl)chloromethylidene-N'-phenylchloromethylidenehydrazine [ No CAS ]
tris{2-[5-(2-methylphenyl)-4-(2,6-dimethylpyridin-3-yl)-4H-1,2,4-triazol-3-yl-κN²]phenyl-κC}iridium(III) [ No CAS ]

Reference： [1]Patent: US2017/271600,2017,A1

81
[ 3430-33-9 ]
2,6-dimethyl-3-amino-5-bromopyridine [ No CAS ]

Reference： [1]Patent: CN107311919,2017,A
[2]Patent: CN109748853,2019,A

82
[ 3430-33-9 ]
[ 3430-34-0 ]

Reference： [1]Patent: CN107311919,2017,A
[2]Patent: CN109748853,2019,A

83
[ 3430-33-9 ]
2-bromo-4-[(2,6-dimethylpiperidin-3-yl)amino]thieno[3,2-c]pyridine-7-carbonitrile [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

84
[ 3430-33-9 ]
[ 912368-95-7 ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

85
[ 3430-33-9 ]
4-[(2,6-dimethylpiperidin-3-yl)amino]-2-phenylthieno[3,2-c]pyridine-7-carboxamide [ No CAS ]
4-[cis-(cis-2,6-dimethylpiperidin-3-yl)amino]-2-phenylthieno[3,2-c]pyridine-7-carboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1061 - 1073

86
[ 3430-33-9 ]
4-(((4-fluorophenyl)sulfonamido)methyl)benzoic acid [ No CAS ]
N-(2,6-dimethylpyridin-3-yl)-4-(((4-fluorophenyl)sulfonamido)methyl)benzamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl acetamide; at 20℃; for 24h;	To a mixture of 211 (0.62 g, 2.0 mmol), <strong>[3430-33-9]3-amino-2,6-dimethylpyridine</strong> (0.26 g, 2.1 mmol), HOBt (0.30 g, 2.2 mmol), and TEA (1 mL) in DMA (5 mL) was added EDCI (0.42 g, 2.2 mmol). After stirring at rt for 24 h, the reaction was quenched with water (100 mL). The resulting precipitate was filtered and recrystallized from CH3CN to give N-(2,6-dimethylpyridin-3-yl)-4-(((4-fluorophenyl)sulfonamido)methyl)benzamide (28) (0.51 g, 91%) as a white solid.

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2020,vol. 30

87
[ 3430-33-9 ]
4-(((4-fluorophenyl)sulfonamido)methyl)benzoic acid [ No CAS ]
N-(2,6-dimethylpyridin-3-yl)-4-(((4-(4-methylpiperazin-1-yl)phenyl)sulfonamido)methyl)benzamide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2020,vol. 30

88
[ 3430-33-9 ]
3-(2-chloro-5-methylpyrimidin-4-yl)-1H-indole-7-carboxylic acid [ No CAS ]
3-(2-chloro-5-methylpyrimidin-4-yl)-N-(2,6-dimethylpyridin-3-yl)-1H-indole-7-carboxamide [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2020,vol. 63,p. 4517 - 4527

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P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 3430-33-9 ] {[proInfo.proName]}

Quality Control of [ 3430-33-9 ]

Related Doc. of [ 3430-33-9 ]

Product Details of [ 3430-33-9 ]

Calculated chemistry of [ 3430-33-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 3430-33-9 ]

Application In Synthesis of [ 3430-33-9 ]

[ 3430-33-9 ] Synthesis Path-Upstream 1~10

[ 3430-33-9 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 3430-33-9 ]

Amines

Related Parent Nucleus of [ 3430-33-9 ]

Pyridines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 3430-33-9 ]

Related Parent Nucleus of
[ 3430-33-9 ]