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Chemical Structure| 34403-03-7 Chemical Structure| 34403-03-7

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Chemical Structure| 34403-03-7

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Product Details of [ 34403-03-7 ]

CAS No. :34403-03-7
Formula : C15H14O
M.W : 210.27
SMILES Code : O=C(C1=CC=CC=C1)CC2=CC=CC(C)=C2
MDL No. :MFCD02260689

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34403-03-7 ]

[ 34403-03-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 178686-24-3 ]
  • [ 34403-03-7 ]
  • [ 57-13-6 ]
  • [ 1283117-19-0 ]
YieldReaction ConditionsOperation in experiment
2.6% With hydrogenchloride; In ethanol; water; for 96.0h;Reflux; [00162] To a solution of l-phenyl-2-m-tolylethanone (Intermediate 4) (460 mg, 2.18 mmol), <strong>[178686-24-3]3-ethoxy-4-hydroxy-5-nitrobenzaldehyde</strong> (460 mg, 2.18 mmol) and urea (300 mg, 6.54 mmol) in 20 mL of ethanol was added 0.2 mL of concentrated HC1, the mixture was stirred at reflux for 4 days. After the solvent was removed under reduced pressure, the residue was purified by HPLC (38-68% acetonitrile + 0.1% trifluoroacetic acid in water, over 15 min.) and thin layer chromatography (PE:EtOAc=l:2) to give Compound 17 (25 mg, yield 2.6%). 1H NMR (CD3OD 400 MHz): delta 7.62 (s, 1H), 7.27 (s, 5H), 7.18 (d, J = 1.6 Hz, 1H), 6.95 (t, J = 1.6 Hz, 1H), 6.88 (d, J = 1.6 Hz, 1H), 6.74 (s, 1H), 6.67 (d, J = 1.6 Hz, 1H), 5.36 (s, 1H), 4.07 (m, 2H), 2.10 (s, 3H), 1.41 (t, J = 6.8 Hz, 3H); MS (ESI): m/z 446.2 [M+l]+.
 

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