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[ CAS No. 3453-33-6 ] {[proInfo.proName]}

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Product Details of [ 3453-33-6 ]

CAS No. :3453-33-6 MDL No. :MFCD00081152
Formula : C12H10O2 Boiling Point : -
Linear Structure Formula :- InChI Key :VZBLASFLFFMMCM-UHFFFAOYSA-N
M.W : 186.21 Pubchem ID :76991
Synonyms :
Chemical Name :6-Methoxy-2-naphthaldehyde

Safety of [ 3453-33-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 3453-33-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 3453-33-6 ]
  • Downstream synthetic route of [ 3453-33-6 ]

[ 3453-33-6 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 3453-33-6 ]
  • [ 17579-79-2 ]
Reference: [1] Tetrahedron, 2002, vol. 58, # 26, p. 5251 - 5265
  • 2
  • [ 3453-33-6 ]
  • [ 2700-47-2 ]
Reference: [1] Advanced Synthesis and Catalysis, 2015, vol. 357, # 8, p. 1721 - 1731
  • 3
  • [ 3453-33-6 ]
  • [ 23981-47-7 ]
Reference: [1] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 9, p. 759 - 763
  • 4
  • [ 3453-33-6 ]
  • [ 78119-82-1 ]
YieldReaction ConditionsOperation in experiment
0.23 g With pyridine hydrochloride In 1-methyl-pyrrolidin-2-one at 110℃; for 24 h; In 25ml single neck RBF 6-methoxy-2-naphthaldehyde (0.5g, 0.00268mo1e), pyridine hydrochloride ( 1.24g, 0.OlO7mole) in 5m1 NMPO was heated at 110 CC for 24h. Progress of the reaction was monitored by TLC. Reaction mixture was then cooled and diluted with water. The product was exctracted to ethyl acetate, dried over anhydrous sodium sulphate and distilled. The crude product was then purifiedthrough silica gel column using dichloromethane and methanol ( 1-5percent) as eluent. Yield: 0.23g; Purity: 99.8percent; ‘H-NMR(CDCI3): 7.25 (dd, 2H, ArH), 7.7(d, 1H, ArH), 7.8(dd, 2H, ArH), 8.3 (d, 1H, ArH), 10.1(s, 1H, CHO); MS: 173 (M+1)
Reference: [1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 5, p. 1819 - 1828
[2] Patent: WO2013/48832, 2013, A1, . Location in patent: Page/Page column 46
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