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Chemical Structure| 34551-17-2 Chemical Structure| 34551-17-2

Structure of 34551-17-2

Chemical Structure| 34551-17-2

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Product Details of [ 34551-17-2 ]

CAS No. :34551-17-2
Formula : C8H7ClN2S
M.W : 198.67
SMILES Code : CNC1=NC2=CC(Cl)=CC=C2S1
MDL No. :MFCD04111218

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Application In Synthesis of [ 34551-17-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34551-17-2 ]

[ 34551-17-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 34551-17-2 ]
  • [ 618910-07-9 ]
  • C21H22N4OS [ No CAS ]
YieldReaction ConditionsOperation in experiment
15% With chloro-(2-dicyclohexylphosphino-2?,6?-diisopropoxy-1,1?-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; lithium hexamethyldisilazane; ruphos; In tetrahydrofuran; for 2.0h;Reflux; General procedure: To degassed tetrahydrofuran (5 mL) was added chloro-(2-dicyclohexylphosphino-2',6'-diisopropoxy-1 ,1 '-biphenyl)[2-(2-aminoethyl)phenyl]palladium(ll)-methyl-f-butyl ether adduct (PdRuPhos G1 ) (0.017 g, 0.024 mmol), 2-dicyclohexylphosphino-2?,6'-diisopropoxybiphenyl (RuPho) (0.011 g, 0.024 mmol), the title compound from Preparative Example 2 (0.05 g, 0.024 mmol), and the commercially available 4-(6-bromobenzo[d]thiazol-2-yl)morpholine (0.073 g, 0.029 mmol). Then, a 1 M solution of lithium bis(trimethylsilyl)amide (LiHMDS) in tetrahydrofuran (1 mL, 1 mmol) was added. The resulting reaction mixture was heated at reflux for 2 hours. The reaction mixture was cooled to room temperature, dissolved in dichloromethane (100 mL). The organic phase was washed with water and brine and dried over Na2S04. The solvent was removed under reduced pressure. The crude product was purified on a silica gel column using a Biotage Isolera One purification system employing an ethyl acetate/n-heptane gradient (80/20 => 100/0) to afford the title compound (0.070 g, 69 %).
 

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