Home Cart 0 Sign in  

[ CAS No. 346721-91-3 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 346721-91-3
Chemical Structure| 346721-91-3
Structure of 346721-91-3 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 346721-91-3 ]

Related Doc. of [ 346721-91-3 ]

Alternatived Products of [ 346721-91-3 ]

Product Details of [ 346721-91-3 ]

CAS No. :346721-91-3 MDL No. :MFCD00592553
Formula : C11H12BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 254.12 Pubchem ID :-
Synonyms :

Safety of [ 346721-91-3 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 346721-91-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 346721-91-3 ]

[ 346721-91-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 123-75-1 ]
  • [ 1711-09-7 ]
  • [ 346721-91-3 ]
YieldReaction ConditionsOperation in experiment
100% In dichloromethane at 0 - 20℃; for 4h; 229 [0442] A solution of 3-bromo-benzoyl chloride (2.7 g, 12 mmol) in DCM (40 mL) was chilled to zero degrees and treated with pyrrolidine (3 mL, 36.8 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (3.1g, 100%).
82% In dichloromethane at 20℃; Cooling with ice; 3 INTERMEDIATE 3(3-Bromophenv0(pyrrolidin- 1 -vDmethanone 3-Bromobenzoyl chloride (658 mg, 3 mmol) was added to a stirred solution of pyrrolidine (1 mL) in DCM (10 mL), pre-cooled in an ice- water bath. The reaction mixture was stirred, then allowed to warm to r.t. After 3 h the mixture was partitioned between water and DCM (10 mL each), and the aqueous phase further extracted with DCM (20 niL). The combined organic phases were dried (MgSO4) and the solvent removed in vacuo. The residue was purified by column chromatography (SiO2, 20-100% EtOAc in heptane) to give the title compound (625 mg, 82%) as a colourless oil. 6H (CDCl3) 8.66 (t, IH), 7.55 (m, IH), 7.44 (m, IH), 7.28 (t, IH), 3.64 (t, 2H), 3.41 (t, 2H), 2.03-1.84 (m, 4H). LCMS (ES+) 254 (M+H)+, RT 3.01 minutes.
With triethylamine In dichloromethane at 20℃; for 2h;
  • 2
  • [ 346721-91-3 ]
  • [ 14394-70-8 ]
  • [ 936092-82-9 ]
YieldReaction ConditionsOperation in experiment
53% With caesium carbonate;tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160℃; for 0.3h;Microwave irradiation; [0443] A mixture of <strong>[14394-70-8]2-chloro-5-methyl-pyrimidin-4-ylamine</strong> (0.22 g, 1.5 mmol), intermediate 81 (0.46 g, 1.8 mmol), Pd2(dba)3 (0.14 g, 0.15 mmol), Xantphos (0.17 g, 0.3 mmol) and cesium carbonate (1.5 g, 4.5 mmol) were suspended in dioxane (8 mL) microwaved at 160 0C for 18 min. Reaction vessel was then centrifuged down and decanted. Solvents then evaporated and resulting residue was purified by flash chromatography on silica gel to afford title compound as white solids (0.25 g, 53%).
  • 3
  • [ 346721-91-3 ]
  • [ 99586-31-9 ]
Same Skeleton Products
Historical Records