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Chemical Structure| 349-57-5 Chemical Structure| 349-57-5

Structure of 349-57-5

Chemical Structure| 349-57-5

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Product Details of [ 349-57-5 ]

CAS No. :349-57-5
Formula : C7H4F3NO3
M.W : 207.11
SMILES Code : OC1=CC(=CC(=C1)C(F)(F)F)[N+]([O-])=O
MDL No. :MFCD04973779
InChI Key :JDIAMHNYAPDMRB-UHFFFAOYSA-N
Pubchem ID :2756251

Safety of [ 349-57-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 349-57-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 349-57-5 ]

[ 349-57-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 13220-33-2 ]
  • [ 349-57-5 ]
  • [ 1529769-19-4 ]
YieldReaction ConditionsOperation in experiment
67% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20℃; for 15h;Cooling with ice; Add 3-nitro-5-(trifluoromethyl)phenol (1.6 g, 7.7 mmol), l-methylpyrrolidin-3-ol (940 9.3 mmol), triphenylphosphine (3.4 g, 11.6 mmol) in THF (20 mL), stir on ice bath, then add diethyl azodicarboxylate (DEAD, 2.0 g, 11.6 mmol). Stir the mixture at ambient temperature for 15 hrs. Add water (100 mL), then extract the mixture with ethyl acetate (100 mLx3), combine the organic layers and dry over anhydrous sodium sulfate. Filter and concentrate the filtrate to get the crude product. Purify by flash chromatography (silica gel, DCM:MeOH=20:l) to afford the target product (1.5 g, 67percent). MS: (M+l): 291.1.
67% With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 25℃; for 15h;Cooling with ice; Add 3-nitro-5-(trifluoromethyl)phenol (1.6 g, 7.7 mmol), 1-methylpyrrolidin-3-ol (940 mg, 9.3 mmol), triphenylphosphine (3.4 g, 11.6 mmol) in THF (20 mL), stir on ice bath, then add diethyl azodicarboxylate (DEAD, 2.0 g, 11.6 mmol). Stir the mixture at ambient temperature for 15 hrs. Add water (100 mL), then extract the mixture with ethyl acetate (100 mL*3), combine the organic layers and dry over anhydrous sodium sulfate. Filter and concentrate the filtrate to get the crude product. Purify by flash chromatography (silica gel, DCM:MeOH=20:1) to afford the target product (1.5 g, 67percent). MS: (M+1): 291.1.
  • 2
  • [ 13220-33-2 ]
  • [ 349-57-5 ]
  • [ 1529769-20-7 ]
 

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