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Chemical Structure| 35139-67-4 Chemical Structure| 35139-67-4

Structure of Minoxidil Impurity A
CAS No.: 35139-67-4

Chemical Structure| 35139-67-4

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Product Details of [ 35139-67-4 ]

CAS No. :35139-67-4
Formula : C4H5ClN4O
M.W : 160.56
SMILES Code : [O-][N+]1=C(N)C=C(Cl)N=C1N
MDL No. :MFCD00134274
InChI Key :DOYINGSIUJRVKA-UHFFFAOYSA-N
Pubchem ID :1551525

Safety of [ 35139-67-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 35139-67-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35139-67-4 ]

[ 35139-67-4 ] Synthesis Path-Downstream   1~2

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  • [ 110-89-4 ]
  • [ 35139-67-4 ]
  • [ 38304-91-5 ]
  • 2
  • [ 35139-67-4 ]
  • [ 38304-91-5 ]
YieldReaction ConditionsOperation in experiment
80% at 106.0℃; for 2.0h; In a round-bottom flask equipped with magnetic stirrer and condenser, a mixture of piperidine (1.8 mL, 1.55g, 18.2 mmol) and 2,6-diamino-4-chloro-pyrimidine N -oxide (0.16 g, 1 mmol) was placed and then stirred inboiling piperidine (106 C) for 120 min. Progress of the reaction was monitored by TLC. After the reaction wascompleted, the excess amount of piperidine was removed by evaporation under reduced pressure. The resultingsolid material was washed with water, recrystallized from hot water affording minoxidil as a colorless crystallinesolid (80% yield, 0.17g, mp. 258?260 C). 1 H NMR (d6 -DMSO) (ppm) 6.83 (bs, 4H, 2NH2) , 5.35 (s, 1H,Ar-H), 3.36 (t, J = 5.32 Hz, 4H, 2CH2 -N), 1.62-1.44 (m, 6H, 3CH2) ; 13 C NMR (d6 -DMSO) (ppm) 155.52,153.47, 152.27, 73.52, 45.39, 25.36, 24.58; FT-IR (max , cm1 , neat) 3307, 2932, 2853, 2261, 2140, 1651, 1611,1475, 1445, 1374, 1287, 1249, 1228, 1150, 1124, 1083, 1023, 1004, 876, 820, 761, 481.
 

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