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Chemical Structure| 35161-71-8 Chemical Structure| 35161-71-8

Structure of 35161-71-8

Chemical Structure| 35161-71-8

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Product Details of [ 35161-71-8 ]

CAS No. :35161-71-8
Formula : C4H7N
M.W : 69.11
SMILES Code : C#CCNC
MDL No. :MFCD00008573
InChI Key :HQFYIDOMCULPIW-UHFFFAOYSA-N
Pubchem ID :96160

Safety of [ 35161-71-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H314
Precautionary Statements:P210-P235-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P370+P378-P403+P235-P405-P501
Class:3(8)
UN#:2733
Packing Group:

Application In Synthesis of [ 35161-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35161-71-8 ]

[ 35161-71-8 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 35161-71-8 ]
  • [ 54589-54-7 ]
  • [ 138591-68-1 ]
  • 2
  • [ 35161-71-8 ]
  • [ 87901-81-3 ]
  • 2-(6-Methoxy-naphthalen-1-yl)-N-methyl-N-prop-2-ynyl-acetamide [ No CAS ]
  • 3
  • [ 35161-71-8 ]
  • [ 10241-97-1 ]
  • [ 1250829-38-9 ]
  • 4
  • [ 35161-71-8 ]
  • [ 151229-84-4 ]
  • [ 1335032-42-2 ]
  • [ 1335032-43-3 ]
YieldReaction ConditionsOperation in experiment
66%; 21% With triethylamine; In tetrahydrofuran; ethanol; for 1.5h;Reflux; General procedure: The corresponding 2-amino-6-chloropyridine-3,5-dicarbonitrile (12 [36]-13 [37]) or <strong>[151229-84-4]2,6-dichloropyridine-3,5-dicarbonitrile</strong>s (14 [27]-15 [28]) were suspended in a mixture of THF/EtOH (2:1, v:v). Then, the corresponding amine, followed by triethylamine, was added, and the mixture heated under reflux. After cooling, the solvent was removed in vacuo and the resulting crude submitted to flash column chromatography, to give compounds 16-19.
  • 5
  • [ 35161-71-8 ]
  • [ 76-09-5 ]
  • [ 51323-43-4 ]
  • C17H24BNO2 [ No CAS ]
  • 6
  • [ 35161-71-8 ]
  • [ 5683-31-8 ]
  • N-methyl-N-(prop-2-ynyl)-3-(trimethylsilyl)propiolamide [ No CAS ]
  • 7
  • [ 35161-71-8 ]
  • [ 41014-43-1 ]
  • N-(benzo[d]oxazol-2-ylmethyl)-N-methylprop-2-yn-1-amine [ No CAS ]
  • 8
  • [ 35161-71-8 ]
  • [ 40299-87-4 ]
  • 2-(methyl(prop-2-yn-1-yl)amino)-1-morpholinoethan-1-one [ No CAS ]
  • 9
  • [ 35161-71-8 ]
  • [ 24078-12-4 ]
  • N-(4-bromo-2-methylbenzyl)-N-methylprop-2-yn-1-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
85% General procedure: Aldehyde (3 mmol) was taken up in dry DCM (10 mL) in an oven dried round bottomed flask under an atmosphere of nitrogen. Acetic acid (1 mmol) was added and the reaction stirred at room temperature for 5 minutes. Amine (1 mmol) was then added and the reaction stirred at room temperature for 1 hour. The reaction was cooled to 0 C using an ice bath, then sodium triacetoxyborohydride (3 mmol) was added and the reaction warmed to room temperature and stirred until TLC indicated complete consumption of the amine. The reaction was quenched with saturated aqueous sodium bicarbonate solution. The organic layer was washed with three portions of saturated sodium bicarbonate, then acidified with concentrated hydrochloric acid. The organic layer was then washed with three portions of 2 M aqueous hydrochloric acid. The pH of the acidic washes was then adjusted to pH 10 using 4 M aqueous sodium hydroxide and the aqueous extracted with three portions of diethyl ether. The combined ether washes were dried with magnesium sulfate, filtered and concentrated to give crude product. The residue was then purified by flash column chromatography and sent to NKI for biological testing.
  • 10
  • [ 35161-71-8 ]
  • [ 13421-00-6 ]
  • 5-chloro-2-iodo-N-methyl-N-(prop-2-yn-1-yl)benzamide [ No CAS ]
 

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