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Chemical Structure| 3524-43-4 Chemical Structure| 3524-43-4

Structure of 3524-43-4

Chemical Structure| 3524-43-4

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Product Details of [ 3524-43-4 ]

CAS No. :3524-43-4
Formula : C10H18N4
M.W : 194.28
SMILES Code : NC1=CC(C)=NN1C2CCN(C)CC2
MDL No. :MFCD03627790

Safety of [ 3524-43-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 3524-43-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3524-43-4 ]

[ 3524-43-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21080-80-8 ]
  • [ 3524-43-4 ]
  • [ 1354822-49-3 ]
YieldReaction ConditionsOperation in experiment
76% In toluene; at 70℃; for 5h; Intermediate 39Ethyl 6-cyclopropyl-3-methyl-l-(l-methyl-4-piperidinyl)-lH-pyrazolo[3,4-6]pyridine-4-carbox late3 -Methyl- l-(l-methyl-4-piperidinyl)-lH-pyrazol-5 -amine (500 mg, 2.57 mmol) and <strong>[21080-80-8]ethyl 4-cyclopropyl-2,4-dioxobutanoate</strong> (474 mg, 2.57 mmol) were suspended in Toluene (10 mL) and heated at 70 °C for 5 h. The solvent was removed in vacuo and the crude residue was purified via silica gel chromatography (eluent: gradient of 0 to 10percent MeOH:DCM). The final product was collected as a solid, 0.722 g (76percent). LCMS E-S (M+H) = 343.1 1H NMR (400 MHz, DMSO-d6) delta ppm 1.03 - 1.11 (m, 4 H), 1.38 (t, J=7.07 Hz, 3 H), 1.83 (d, J=6.06 Hz, 2 H), 2.12 - 2.22 (m, 4 H), 2.27 (s, 3 H), 2.35 (m, J=7.83, 7.83, 5.05, 4.80 Hz, 1 H), 2.54 (s, 3 H), 2.94 (d, J=6.57 Hz, 2 H), 4.42 (q, J=7.16 Hz, 2 H), 4.57 - 4.73 (m, 1 H), 7.46 (s, 1 H).
 

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