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Chemical Structure| 352553-60-7 Chemical Structure| 352553-60-7

Structure of 352553-60-7

Chemical Structure| 352553-60-7

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Product Details of [ 352553-60-7 ]

CAS No. :352553-60-7
Formula : C12H13ClN2
M.W : 220.70
SMILES Code : NC1C(NC2=C3C=C(Cl)C=C2)=C3CCC1
MDL No. :MFCD01241897

Safety of [ 352553-60-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 352553-60-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 352553-60-7 ]

[ 352553-60-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 352553-60-7 ]
  • [ 402-69-7 ]
  • [ 125700-67-6 ]
  • [ 913961-51-0 ]
YieldReaction ConditionsOperation in experiment
61% With N-ethyl-N,N-diisopropylamine; In dichloromethane; water; Example 60 N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-6-fluoro-2-pyridinecarboxamide To a solution of 6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine (0.15 g, 0.68 mmol), DIPEA (0.165 mL, 0.123 g, 0.95 mmol) and 2-fluoro-6-pyridine carboxylic acid (0.115 g, 0.816 mmol) in dichloromethane (5 mL) was added O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU, 0.26 g, 0.81 mmol) and the mixture was stirred at ambient temperature for 2 h. Water was added and after 10 min, the organic phase was separated and washed with saturated NaHCO3/water, dried (Na2SO4), evaporated, and chromatographed (Silica gel, EtOAc/hexanes, 0-30percent) to provide the title compound as an off-white solid (0.13 g, 61percent yield). 1H-NMR (DMSO-d6): delta 10.92 (s, 1H), 8.8 (d, 1H), 8.2 (quartet, 1H), 8.04 (dd, 1H), 7.43 (m, 2H), 7.28 (d, 1H), 7.0 (dd, 1H), 5.37 (quartet, 1H), 2.62 (m, 2H), 2.0 (m, 3H), 1.8 (m, 1H); MS m/z 365 (M+Na).
  • 2
  • [ 352553-60-7 ]
  • [ 1072-84-0 ]
  • N-(6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-1H-imidazole-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
4% Example 50 N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-1H-imidazole-4-carboxamide N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-1H-imidazole-4-carboxamide was prepared from 4-imidazole carboxylic acid and 6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine in a similar manner as described above to give a white solid (4percent yield). 1H-NMR (CDCl3): delta 9.19 (s, 1H), 7.62 (s, 1H), 7.57 (s, 1H), 7.41 (s, 1H), 7.37 (d, 1H), 7.17 (d, 1H), 7.05 (dd, 1H), 6.60 (d, 1H), 5.25 (m, 1H), 2.62 (m, 2H), 2.21 (m, 1H), 1.91 (m, 3H); MS m/z 313 (M-1).
 

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