Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 35387-93-0 | MDL No. : | MFCD00052925 |
Formula : | C9H9IO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | GHNGBFHLUOJHKP-UHFFFAOYSA-N |
M.W : | 292.07 | Pubchem ID : | 316980 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper at 260℃; | ||
With copper at 220 - 230℃; | ||
Multi-step reaction with 2 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / 20 - 90 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 14 h / 20 - 90 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28% | With copper at 220℃; for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95.1% | With aluminium trichloride In dichloromethane; ethanethiol for 6.5h; temp. 0 deg C -> RT; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(i) 1-iodo-2,4-dimethoxy-benzene, Cu, (ii) NaOH, EtOH; Multistep reaction; | ||
(i) Cu, (ii) NaOH, EtOH; Multistep reaction; | ||
Multi-step reaction with 2 steps 1: copper-powder / 260 °C 2: aq.-ethanolic KOH-solution |
Multi-step reaction with 3 steps 1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 16 h / 20 - 90 °C 2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / 1,4-dioxane / 14 h / 20 - 90 °C 3: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With pyrrolidine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran a) 60 deg C, 1 h, b) 20 deg C, 15 h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With sodium hydrogen telluride; acetic acid In ethanol for 4h; Heating; Yields of byproduct given; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With indium(III) triflate; N-iodo-succinimide In acetonitrile at 23℃; for 36h; Inert atmosphere; Darkness; | |
91% | With N-iodo-succinimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In dichloromethane; toluene at 40℃; for 14h; | General Procedure: General procedure: To a stirred solution of the substrate (1 mmol) in CH2Cl2 or (CH2Cl)2 (0.1 M) were added Ph3PAuNTf2 (0.025 mmol, 19 mg; complex Ph3PAuNTf2 toluene, 2:1) followed by N-iodosuccinimide (1.1 mmol, 248 mg). The resulting solution was stirred at r.t. or under reflux until complete conversion of the starting material. After removal of the solvent under reduced pressure, the crude material was purified by flash column chromatography using different gradients of hexanes and EtOAc to obtain the pure desired products. |
85% | With iodine; 1-(p-methylbenzenesulfonyloxy)-1,2-benziodoxol-3-(1H)-one In acetonitrile for 16h; Ambient temperature; |
85% | With sodium percarbonate; sulfuric acid; iodine at 45 - 50℃; for 2h; | |
67% | With sodium iodate; iodine In sulfuric acid at 25 - 30℃; for 1h; | |
67% | With sodium periodate; sulfuric acid; potassium iodide at 25 - 30℃; for 0.25h; | |
58% | Stage #1: methyl 4-methoxybenzoate With iodine In tetrachloromethane for 0.166667h; Stage #2: With nitric acid In tetrachloromethane for 3.5h; Heating / reflux; | 8 Example 8; Methyl 3-iodo-4-methoxybenzoate To a solution of methyl 4-methoxybenzoate (29.7 g, 0.18 mol) in CCl4 (110 mL) iodine (22.7 g, 0.89 mol) was added and the mixture was stirred for 10 min. Nitric acid (58%, 50 mL) was added dropwise wiwhin 30 min and the mixture was refluxed for 3 h. The mixture was cooled to room temperature and precipitate formed was filtered off. The organic layer was separated, washed with 5% Na2SO3 (100 mL), dried over CaCl2 and evaporated. The residue was combined with the precipitate and recrystallized twice from EtOH. Yield 30.4 g (58%). |
58% | Stage #1: methyl 4-methoxybenzoate With iodine In tetrachloromethane for 0.166667h; Stage #2: With nitric acid In tetrachloromethane; water Reflux; | |
47% | With Iron(III) nitrate nonahydrate; carbon dioxide; iodine; oxygen In ethylene glycol at 100℃; for 10h; Autoclave; Green chemistry; regioselective reaction; | |
42% | With dihydrogen peroxide; iodine; acetic anhydride; urea In acetic acid at 10 - 15℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With copper(l) iodide; triethylamine In tetrahydrofuran | ||
With bis-triphenylphosphine-palladium(II) chloride; triethylamine In N,N-dimethyl-formamide at 60℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With Ti2CO3 In tetrahydrofuran for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With Ti2CO3 In benzene for 30h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With Ti2CO3 In benzene for 30h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 45% 2: 19% | With TlOH In benzene Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With silver carbonate In benzene Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
11% | With Ti2CO3 In benzene for 168h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Et3N; CuI / (Ph3P)2PdCl2 / tetrahydrofuran 2: MnO2 / CH2Cl2 / 8 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: Et3N; CuI / (Ph3P)2PdCl2 / tetrahydrofuran 2: MnO2 / CH2Cl2 / 8 h / 20 °C 3: 85 percent / toluene; CHCl3 / 4 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C 2: H2 / Pd/C / ethyl acetate / 1 h / 1551.49 Torr 3: PPh3; CBr4 / CH2Cl2 / 0.5 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C 2: H2 / Pd/C / ethyl acetate / 1 h / 1551.49 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C 2: H2 / Pd/C / ethyl acetate / 1 h / 1551.49 Torr 3: PPh3; CBr4 / CH2Cl2 / 0.5 h / 0 °C 4: NaH; NaI / dimethylformamide 5: NaBH4 / methanol; CH2Cl2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C 2: H2 / Pd/C / ethyl acetate / 1 h / 1551.49 Torr 3: PPh3; CBr4 / CH2Cl2 / 0.5 h / 0 °C 4: NaH; NaI / dimethylformamide |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: (PPh3)2Pd(Cl)2; Et3N / dimethylformamide / 60 °C 2: H2 / Pd/C / ethyl acetate / 1 h / 1551.49 Torr 3: PPh3; CBr4 / CH2Cl2 / 0.5 h / 0 °C 4: NaH; NaI / dimethylformamide 5: NaBH4 / methanol; CH2Cl2 6: aq. NaOH / dioxane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 100 percent / pyrrolidine, Pd(PPh3)4, CuI / tetrahydrofuran / a) 60 deg C, 1 h, b) 20 deg C, 15 h 2: aq. NaOH / tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 100 percent / pyrrolidine, Pd(PPh3)4, CuI / tetrahydrofuran / a) 60 deg C, 1 h, b) 20 deg C, 15 h 2: 59 percent / H2 / 5percent Pd/C / methanol / 120 h / 2585.7 Torr |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 100 percent / pyrrolidine, Pd(PPh3)4, CuI / tetrahydrofuran / a) 60 deg C, 1 h, b) 20 deg C, 15 h 2: 59 percent / H2 / 5percent Pd/C / methanol / 120 h / 2585.7 Torr 3: 93 percent / aq. NaOH / tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 100 percent / pyrrolidine, Pd(PPh3)4, CuI / tetrahydrofuran / a) 60 deg C, 1 h, b) 20 deg C, 15 h 2: 59 percent / H2 / 5percent Pd/C / methanol / 120 h / 2585.7 Torr 3: 93 percent / aq. NaOH / tetrahydrofuran 4: 20 percent / EDCI, Et3N, 4-(dimethylamino)pyridine / tetrahydrofuran; CH2Cl2 / 12 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 100 percent / pyrrolidine, Pd(PPh3)4, CuI / tetrahydrofuran / a) 60 deg C, 1 h, b) 20 deg C, 15 h 2: aq. NaOH / tetrahydrofuran 3: 45 percent / EDCI, Et3N, 4-(dimethylamino)pyridine / tetrahydrofuran; CH2Cl2 / 72 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
[00381] In a reaction tube under nitrogen, a mixture of PdCl2(dppf)CH2Cl2 (21 mg; 0.026 mmol) and triethylamine (0.34 ml; 2.44 mmol) in dioxane (2.5 ml; dried over 4 A sieves) was sealed and stirred at 80 C. overnight (18 h). After cooling to room temperature, HB(pin) (0.19 ml; 1.31 mmol) was added followed by methyl 3-iodo-4-methoxybenzoate (251 mg; 0.859 mmol) in dioxane (2.5 ml; dried over 4 A sieves) the reaction mixture was stirred at 80 C. GC analysis after 18 hours showed the desired borate compound at 13.0 minutes. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrogenchloride; lithium hydroxide; In THF-MeOH-water; | 3-Iodo-4-methoxybenzoic acid (26). Lithium hydroxide (72 mg, 1.71 mmol) was added to a mixture of methyl 3-iodo-4-methoxybenzoate (100 mg, 0.342 mmol) in 3.0 mL of a 3:1:1 THF-MeOH-water solution at room temperature. The mixture was stirred for eight hours in the dark and than diluted with H2O (2 mL). The solution was acidified to pH=2 by the dropwise addition of concentrated HCl. The solution was extracted twice with EtOAc (10 mL portions) and the combined organic layers dried (Na2SO4), filtered, and concentrated to afford acid 26 (95 mg, 100%) as a yellow solid that was suitable for use without further purification: 1H NMR (400 MHz, DMSO) delta 8.24 (d, J=2.0 Hz, 1H), 7.92 (dd, J=2.0, 8.7 Hz, 1H), 7.07 (d, J=8.7 Hz, 1H), 3.88 (s, 3H). |
96.7% | With ethanol; sodium hydroxide; In tetrahydrofuran; at 55℃; for 1h; | Compound 37 (3.0 g, 10.27 mmol) was dissolved in THF (10 mL) and ethanol (10 mL). 2M sodium hydroxide solution (20 mL) was added. The resulting mixture was stirred at 55 C for 1 hour. About half of the solvent was distilled off under reduced pressure. Water (60 mL) was added. Adjust the pH value with dilute hydrochloric acid to 1 ~ 2. Extraction with ethyl acetate (40 mL x 3). The combined organic phases were washed with saturated brine (20 mL). Dried over anhydrous sodium sulfate.. The solvent was distilled off under reduced pressure to give 3-iodo-4-methoxybenzoic acid (38) (2.76 g). The yield was 96.7%. |
76% | With methanol; lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20℃; | Methyl 3-iodo-4-methoxybenzoate (2.92 g, 10 mmol) was dissolved in a mixture of THF (80 ml_), MeOH (10 ml_), and H2O (20 ml.) and treated with lithium hydroxide monohydrate (840 mg, 20 mmol). The reaction was stirred at room temperature overnight and then concentrated at reduced pressure. The remaining residue was diluted with 50 ml. of H2O and acidified to pH 4.0 with 1 N HCI. The resulting precipitate was collected by suction filtration. The collected precipitate was dried in a vacuum oven at 5O0C for 3 hours to yield 2.77 g (76%) of the carboxylic acid as a white solid. No additional purification of the carboxylic acid was required. |
Methyl 3-iodo-4-methoxybenzoate (29.2 g, 0.1 mol) was suspended in EtOH (150 mL), the solution of NaOH (4.4 g, 0.11 mol) was added in one portion. The mixture was stirred and heated at 40C overnight, then cooled, diluted with water (400 mL). 3-Iodo-4-methoxybenzoic acid was precipitated with conc. HCl, filtered off, washed with cold water, and dried over P4O10. The acid was suspended in CHCl3 (150 mL), and SOCl2 (9.5 mL, 0.13 mmol) was added. The mixture was stirred overnight, then evaporated and the residue was distilled under reduced pressure to give the desired acid chloride as a solid (mp ca. 50C, bp 145-150C/1 Torr). Yield 18.2 g (61%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 3-iodo-4-methoxy-benzoic acid methyl ester With isopropyl magnesium chloride In tetrahydrofuran; diethyl ether at -50 - -40℃; for 1.08333h; Stage #2: With zinc(II) chloride In tetrahydrofuran; diethyl ether at 0℃; for 0.666667h; | 34 Preparation 34; 3-(2-Chloro-4-nitro-benzoyl)-4-methoxy-benzoic acid methyl ester (Compound 434) A dry flask was charged with 3-iodo-4-methoxy-benzoic acid methyl ester (8. 9 G, 30.5 MMOL) and the flask was evaporated and then filled with argon and this process repeated twice. Dry THF (50 mL) was added, and the solution cooled to-50 °C ; then ISOPROPYLMAGNESIUM chloride (15.2 mL, 2.0 M in diethyl ether, 30.5 MMOL) was added slowly over 20 min keeping the temperature below-40 °C. On completion of the addition the reaction mixture was stirred at-40 °C for 45 min. A THF solution of ZINC12 (5.19 G, 38. 1 mmol, 1.0 M) was added dropwise over 20 min. The reaction mixture was stirred at 0 °C for 20 min; then 2-chloro-4-nitro-benzoyl chloride (7.04 G, 32.0 MMOL) and Cu (OAc) 2 (122 mg, 0.61 MMOL) were added and the reaction mixture was allowed to warm to room temperature. After 16 h the reaction mixture was poured into a mixture of EtOAc/water, then shaken and separated. The aqueous phase was extracted with more EtOAc. The organic phases were combined, dried (MGS04), filtered, and concentrated in vacuo to afford the crude product. The crude product was purified by flash chromatography using ETOAC/PETROLEUM ether (40-60) 1: 6 followed by 1: 3 as the eluent to give the title compound as yellow solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium pentane-2,4-dionate In diethyl ether reaction of Zn(iPr)2 with IC6H4(OMe)COOMe in presence of Li(acac) in mixt. of Et2O and N-methylpyrrolidinone; detn. by gas chromy.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate; copper(l) chloride In N,N-dimethyl-formamide; acetonitrile at 120℃; for 12h; solid phase reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 3-iodo-4-methoxy-benzoic acid methyl ester With isopropyl magnesium chloride In tetrahydrofuran at -50℃; for 0.5h; Stage #2: 4-Bromo-2-chloro-thiobenzoic acid S-pyridin-2-yl ester In tetrahydrofuran at 20℃; for 2h; | 41 Preparation 41; 3-(4-Bromo-2-chloro-benzoyl)-4-methoxy-benzoic acid methyl ester (Compound 441) To a solution of 3-iodo-4-methoxy-benzoic acid methyl ester (6.31 G, 21. 6 MMOL) in THF (20 ml) was added 2 M solution of isopropylmagnesium chloride in THF (11.0 ML, 22.00 MMOL) AT-50°C. The reaction mixture was stirred at the same temperature for 30 min. Then compound 440 (5.91 G, 18 MMOL) was added. The solution was warmed- to room temperature and stirred for 2 h at the same temperature. Afterwards, the solution was quenched with saturated aqueous solution of NH4CL. The aqueous phase was extracted twice with diethyl ether. The combined organic phases were dried over MGS04 and concentrated in vacuo. The crude material was dissolved in ethyl acetate and silica gel added. The mixture was concentrated in vacuo. The residue was purified by chromatography (petroleum ether/ethyl acetate 5: 1) to provide title compound as oil, which was solidified to a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With copper(l) iodide; triethylamine In toluene at 110℃; for 6h; Inert atmosphere; | 15.1 Methyl 3-iodo-4-methoxybenzoate (6.0 g, 20.4 mmol), 2-ethynylpyridine (3.14 ml_, 31.1 mmol), and triethylamine (6.2 ml_, 44.7 mmol) were dissolved in 100 ml. of toluene and purged with nitrogen. Then CuI (0.78 g, 3.9 mmol) and Pd(Ph3P)2CI2 (2.9 g, 4.1 mmol) were added and the resulting suspension was stirred at 100 0C for 6 hours. The reaction was concentrated at reduced pressure and purified by flash chromatography on silica (20:1 CH2CI2/Et0Ac) to yield 5.3 g (96%) of product as a brown solid. |
96% | With copper(l) iodide; triethylamine In toluene at 100℃; for 6h; Inert atmosphere; | 1.1 Methyl 3-iodo-4-methoxybenzoate (6.0 g, 20.4 mmol), 2-ethynylpyridine (3.14 ml_, 31.1 mmol), and triethylamine (6.2 ml_, 44.7 mmol) were dissolved in 100 ml. of toluene and purged with nitrogen. Then, CuI (0.78 g, 3.9 mmol) and Pd(Ph3P)2CI2 (2.9 g, 4.1 mmol) were added and the resulting suspension was stirred at 1000C for 6 hours. The reaction was concentrated at reduced pressure and purified by flash chromatography on silica (20:1 CH2CI2/Et0Ac) to yield 5.3 g (96%) of product as a brown solid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81.5% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine at 20℃; for 48h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With copper(l) iodide; triethylamine In toluene at 100℃; for 6h; Inert atmosphere; | 82.1 Methyl 3-iodo-4-methylbenzoate (5.52 g, 20 mmol), 2-ethynylpyridine (3.2 ml_, 31 mmol), and triethylamine (6.2 ml_, 44.7 mmol) were dissolved in 100 ml. of toluene and purged with nitrogen. Then CuI (0.78 g, 3.9 mmol) and Pd(Ph3P)2CI2 (2.9 g, 4.1 mmol) were added and the resulting suspension was stirred at 1000C for 6 hours. The reaction was concentrated at reduced pressure and purified by flash chromatography on silica (40:1 CH2CI2/Et0Ac) to yield 2.63 g (52%) of the product as a greenish solid. HRMS (+ESI): m/z 252.1019 [M+H]+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | Stage #1: cyclohexylmagnesiumchloride With zinc(II) chloride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: 3-iodo-4-methoxy-benzoic acid methyl ester In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 100℃; for 0.666667h; | 3 Preparation of 3-cyclohexyl-4-methoxy-benzoic acid methyl ester 1.2 Preparation of 3-cyclohexyl-4-methoxy-benzoic acid methyl ester 1.2 To 63 mL 0.5M ZnCl2 solution in THF was added 15 mL 2M cyclohexyl-magnesium chloride at room temperature. The mixture was stirred for 20 minutes and then 22 mL NMP was added and the stirring was continued for 5 more minutes. 3-Iodo-4-methoxy-benzoic acid methyl ester 1.1 (2.92 g, 10 mmol) and 102 mg Pd(P(tBu)3)2 were added. The mixture was heated at 100° C. for 40 minutes. The solvent was evaporated and the residue was purified on silica gel using hexane-toluene gradient to yield 1.9 g (70%) 1.2. H1-NMR (DMSO-d6): δ(ppm) 7.78 (dd, 1H, J=8.4 and 2.4 Hz), 7.73 (d, 1H, J=2.4 Hz), 7.03 (d, 1H, J=8.7 Hz), 3.84 (s, 3H), 3.78 (s, 3H), 2.87 (m, 1H), 1.75 (m, 5H), 1.34 (m, 5H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran for 20h; Inert atmosphere; Sealed tube; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With tetrakis(triphenylphosphine) palladium(0); sodium methylate In N,N-dimethyl-formamide at 20℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 60℃; for 6h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: potassium carbonate; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0) / water; 1,4-dioxane 2: lithium hydroxide / tetrahydrofuran; water; methanol 3: pyridine 4: thionyl chloride / tetrahydrofuran 5: pyridine / tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water at 110℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In water at 110℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
36.2% | With tetrabutyl-ammonium chloride; palladium diacetate; triethylamine In N,N-dimethyl-formamide at 120℃; for 12h; Sealed tube; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: ammonia; iodine; potassium iodide / water / 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C 2.2: 20 °C | ||
Multi-step reaction with 2 steps 1: iodine; potassium iodide; ammonia / water / 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
8.4 g | A stirred solution of 4-hydroxybenzoic acid (5.0 g, 36 mmol) inammonia (200 mL) was treated with iodine (9.2 g, 36 mmol) andKI (29.4 g, 180 mmol) in water (100 mL) dropwise at r.t. After theaddition, the mixture was stirred overnight at the same temperature.Then, hydrochloric acid (2.0 mol L-1) was added to adjust the pH ofthe mixture to pH 2.0 and a white solid precipitated. After filtration,the filter cake was washed with water. The white solid was dried andthen dissolved in DMF (100 mL). Next, K2CO3 (5.0 g, 18 mmol) wasadded to the mixture, and it was stirred for 1 h at r.t. Then MeI (2.5 mL,36 mmol) was added and the mixture was stirred overnight. The mixture was diluted with water and extracted with ethyl acetate (2 ×120 mL). The organic layer was washed with water and then dried withanhydrous sodium sulfate. After concentration under reduced pressure,the crude product was purified by column chromatography to givecompound 2b as: White solid17; yield 7.5 g (75%); 1H NMR (400 MHz,DMSO-d6): delta 11.30 (s, 1H), 8.23 (d, J = 2.1 Hz, 1H), 7.82 (dd, J = 8.5,2.1 Hz, 1H), 6.96 (d, J = 8.5 Hz, 1H), 3.80 (s, 3H); 13C NMR (100 MHz,DMSO-d6): delta 164.8, 161.1, 140.2, 131.1, 122.2, 114.6, 84.4, 51.9. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane at 120℃; for 0.5h; Inert atmosphere; Microwave irradiation; | (iii).a Methyl 4-methoxy-3-(pyrimidin-5-yi)benzoate A mixture of methyl 3-iodo-4-methoxybenzoate (500 mg, 1 .71 mmol), pyrimidin-5-ylboronic acid (318 mg, 2.57 mmol), PdCI2(dppf)DCM complex (71 mg, 5 mol%), 1.4-dioxane (10 mL) and aqueous 1 .0 M CS2CO3 (3.42 mL, 3.42 mmol) was degassed with bubbling nitrogen and heated in the microwave (120 C/30 min). The mixture was added to water (100 mL) and EtOAc (100 mL) and the mixture was filtered through Celite. The filtrate was separated and the aqueous phase was extracted with further EtOAc (100 mL). The pooled organic phases were washed with brine (100 mL), dried over Na2SO4 and concentrated. Chromatography (0- 80% EtOAc in petroleum benzine 40-60 C) gave the title product as a white solid (321 mg, 77%). 1H NMR (400 MHz, d6-DMSO) δ 9.18 (s, 1 H), 8.96 (s, 2H), 8.07 (dd, J = 8.7, 2.2 Hz, 1 H), 7.97 (d, J = 2.2 Hz, 1 H), 7.32 (d, J = 8.7 Hz, 1 H), 3.89 (s, 3H), 3.84 (s, 3H). LCMS-B rt 3.45 min; m/z 245.1 [M+H] ' |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; bis(dibenzylideneacetone)-palladium(0) In 1,4-dioxane at 110℃; for 20h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88.4% | With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 2h; | Methyl 3-iodo-4-hydroxybenzoate (4.1 g, 14.75 mmol) was dissolved in DMF (25 mL). Potassium carbonate (2.65 g, 19.20 mmol) and methyl iodide (3.14 g, 22.12 mmol) were added. The resulting mixture was stirred at 60 C for 2 hours. Cooled to room temperature. Water (80 mL) was added. Extraction with ethyl acetate (40 mL x 3). The combined organic phases were washed successively with water (30 mL x 2) and saturated brine (20 mL). Dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The product was recrystallized from petroleum ether to give methyl 3-iodo-4-methoxybenzoate (37) (3.81 g). The yield was 88.4%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | Stage #1: 3-iodo-4-methoxy-benzoic acid methyl ester With isopropylmagnesium bromide In tetrahydrofuran at -40℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: 15-acetoxy-labda-8(9),13E-diene With dilithium tetrachlorocuprate(II) In tetrahydrofuran at -40 - 20℃; Inert atmosphere; Schlenk technique; regioselective reaction; | 15-(2-Methoxyl-5-carbomethoxy)phenyl-labda-8(9),13E-diene (6a) i-PrMgBr (1.05 mmol, 1.56 M in THF) was added to a solution of thearomatic iodide 2c (103 mg, 0.35 mmol) in THF (1.0 mL) at -40 °C andthen stirred for 2 h at this temperature. The solution was thentransferred over 2 min via a syringe to a round-bottom flask containingCuLi2Cl4 (0.023 mmol, 0.05 mol L-1) and the acetate 3c (79 mg, 0.23mmol) in anhydrous THF (1.0 mL) at -40 °C. The reaction was stirredfor 1 h at -40 °C before being warmed to r.t. and stirred overnight. Thereaction was quenched with saturated NH4Cl solution, diluted withwater and extracted with ethyl acetate. The combined organic extractswere washed with brine and dried over Na2SO4. Evaporation of theorganic solvent gave a crude product, which was purified on silica gelto give compound 6a as: Colourless liquid; yield 62.5 mg (62%); α22D =+42.4° (c = 0.5, CHCl3); 1H NMR (400 MHz, CDCl3): δ 7.89 (dd,J = 8.8, 2.2 Hz, 1H), 7.83 (d, J = 2.0 Hz, 1H), 6.85 (d, J = 8.8 Hz, 1H),5.31 (t, J = 7.2 Hz, 1H), 3.88 (s, 3H), 3.87 (s, 3H), 3.33 (d, J = 8 Hz, 2H),2.16-1.76 (m, 8H), 1.73 (s, 3H), 1.72-1.61 (m, 2H), 1.58 (s, 3H),1.50-1.34 (m, 4H), 1.30-1.10 (m, 4H), 0.94 (s, 3H), 0.88 (s, 3H), 0.83(s, 3H); 13C NMR (100 MHz, CDCl3): d 166.7, 160.7, 140.1, 137.3,130.3, 129.7, 128.9, 128.6, 127.3, 125.3, 121.7, 120.6, 109.1, 55.1, 51.5,51.3, 41.4, 40.1, 38.6, 36.6, 33.2, 32.9, 27.7, 26.8, 21.3, 19.7, 19.1, 18.7,15.7. HRMS (NSI) m/z calcd for C29H43O3 [M + H]+: 439.3207; found:439.3201. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions | ||
Multi-step reaction with 2 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C 2.2: pH 4 / Acidic aqueous solution |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h 3.2: 5 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C 4.1: potassium hexamethylsilazane / N,N-dimethyl-formamide; toluene / 0.03 h / -50 °C 4.2: -50 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h 3.2: 5 h 4.1: acetyl chloride / methanol / 0 °C 5.1: triethylamine / isopropyl alcohol / 85 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 110 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate; water / tetrahydrofuran; methanol / 20 °C 2.2: pH 4 / Acidic conditions 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h 3.2: 5 h 4.1: acetyl chloride / methanol / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere 2: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere 2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 20 °C 2.2: pH 4 / Acidic aqueous solution 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h 3.2: 5 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere 2.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C 3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C 3.2: 0.08 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere 2.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C 3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 20 °C 3.2: 0.08 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1.1: methanol; lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C 2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.25 h 2.2: 5 h 3.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / toluene / 100 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | With potassium phosphate; trifuran-2-yl-phosphane; C9H13NO; 2-hydroxy-5-(trifluoromethyl)pyridine; isopropyl alcohol; palladium(II) iodide In 1,4-dioxane; toluene at 100℃; for 16h; Glovebox; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; 2-hydroxy-5-(trifluoromethyl)pyridine; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; C9H13NO / 1,4-dioxane; toluene / 16 h / 100 °C / Glovebox; Inert atmosphere 2: Wilkinson's catalyst / toluene; benzonitrile / 12 h / 130 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With bis(η3-allyl-μ-chloropalladium(II)); C9H13NO; potassium carbonate; 2-hydroxy-5-(trifluoromethyl)pyridine; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine In 1,4-dioxane; toluene at 100℃; for 16h; Glovebox; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: diisobutylaluminium hydride / tetrahydrofuran / 12 h / -78 - 20 °C 2: triethylamine / 2 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 12 h 4: caesium carbonate; 2-hydroxy-5-(trifluoromethyl)pyridine; dichloro bis(acetonitrile) palladium(II); 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine; C9H13NO / 1,4-dioxane; toluene / 16 h / 100 °C / Glovebox; Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diisobutylaluminium hydride In tetrahydrofuran at -78 - 20℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: diisobutylaluminium hydride / tetrahydrofuran / 12 h / -78 - 20 °C 2: triethylamine / 2 h / 20 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: diisobutylaluminium hydride / tetrahydrofuran / 12 h / -78 - 20 °C 2: triethylamine / 2 h / 20 °C / Inert atmosphere 3: potassium carbonate / N,N-dimethyl-formamide / 12 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 49% 2: 29% | With dichloro bis(acetonitrile) palladium(II); C9H13NO; potassium carbonate; 2-hydroxy-5-(trifluoromethyl)pyridine; 2′-(diphenylphosphino)-N,N′-dimethyl-(1,1′-biphenyl)-2-amine In 1,4-dioxane; toluene at 100℃; for 16h; Glovebox; Inert atmosphere; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With triphenyl-arsane; palladium diacetate; silver trifluoroacetate In 1,4-dioxane at 120℃; for 1h; Inert atmosphere; Sealed tube; Schlenk technique; diastereoselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine In tetrahydrofuran at 50℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | Stage #1: 3-iodo-4-methoxy-benzoic acid methyl ester With TurboGrignard In tetrahydrofuran at -30℃; for 1h; Stage #2: 1-bromo-3-methylbuta-1,2-diene With copper(l) iodide In tetrahydrofuran at -30 - 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 70℃; for 12h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; triethylamine / 12 h / 70 °C 2: sodium hydroxide / tetrahydrofuran; methanol / 12 h / 60 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; Bathocuproine at 120℃; for 24h; Inert atmosphere; Sealed tube; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; potassium carbonate In 1,4-dioxane at 130℃; for 16h; |
Tags: 35387-93-0 synthesis path| 35387-93-0 SDS| 35387-93-0 COA| 35387-93-0 purity| 35387-93-0 application| 35387-93-0 NMR| 35387-93-0 COA| 35387-93-0 structure
[ 100725-29-9 ]
Methyl 3-iodo-4-phenoxybenzoate
Similarity: 0.98
[ 1131588-13-0 ]
Methyl 4-ethoxy-3-iodobenzoate
Similarity: 0.98
[ 4253-10-5 ]
Methyl 3,5-diiodo-4-methoxybenzoate
Similarity: 0.98
[ 35387-92-9 ]
Methyl 4-iodo-3-methoxybenzoate
Similarity: 0.98
[ 1131614-03-3 ]
Methyl 4-acetoxy-3-iodobenzoate
Similarity: 0.96
[ 100725-29-9 ]
Methyl 3-iodo-4-phenoxybenzoate
Similarity: 0.98
[ 1131588-13-0 ]
Methyl 4-ethoxy-3-iodobenzoate
Similarity: 0.98
[ 4253-10-5 ]
Methyl 3,5-diiodo-4-methoxybenzoate
Similarity: 0.98
[ 35387-92-9 ]
Methyl 4-iodo-3-methoxybenzoate
Similarity: 0.98
[ 100725-29-9 ]
Methyl 3-iodo-4-phenoxybenzoate
Similarity: 0.98
[ 1131588-13-0 ]
Methyl 4-ethoxy-3-iodobenzoate
Similarity: 0.98
[ 4253-10-5 ]
Methyl 3,5-diiodo-4-methoxybenzoate
Similarity: 0.98
[ 35387-92-9 ]
Methyl 4-iodo-3-methoxybenzoate
Similarity: 0.98
[ 1131614-03-3 ]
Methyl 4-acetoxy-3-iodobenzoate
Similarity: 0.96
[ 100725-29-9 ]
Methyl 3-iodo-4-phenoxybenzoate
Similarity: 0.98
[ 1131588-13-0 ]
Methyl 4-ethoxy-3-iodobenzoate
Similarity: 0.98
[ 4253-10-5 ]
Methyl 3,5-diiodo-4-methoxybenzoate
Similarity: 0.98
[ 35387-92-9 ]
Methyl 4-iodo-3-methoxybenzoate
Similarity: 0.98
[ 1131614-03-3 ]
Methyl 4-acetoxy-3-iodobenzoate
Similarity: 0.96
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :