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Chemical Structure| 354812-10-5 Chemical Structure| 354812-10-5

Structure of 354812-10-5

Chemical Structure| 354812-10-5

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Product Details of [ 354812-10-5 ]

CAS No. :354812-10-5
Formula : C6H6BrN3O2S
M.W : 264.10
SMILES Code : O=C(C1=C(NC(N)=O)SC(Br)=C1)N
MDL No. :MFCD26394864

Safety of [ 354812-10-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 354812-10-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 354812-10-5 ]

[ 354812-10-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 354812-10-5 ]
  • [ 214360-70-0 ]
  • 5-ureido-[2,3'-bithiophene]-4-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% With tetrakis(triphenylphosphine) palladium(0); caesium carbonate; In 1,4-dioxane; water; at 75℃; for 18h;Inert atmosphere; General procedure: To a mixture of 1-(5-bromo-3-carbamoylthiophen-2-yl)urea 8 (53.3 mg, 0.202 mmol) in 1,4-dioxane-H2O (7:1) were added tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxabororan-2-yl)benzylcarbamate 9a (100.9 mg, 0.303 mmol) and Cs2CO3 (263.1 mg, 0.807 mmol) and the mixture was degassed. To the mixture was added tetrakis(triphenylphosphino)palladium (23.3 mg, 0.0202 mmol) and the mixture was stirred at 75 C for 18 h and concentrated. Purification of chromatography (SiO2-amine 20 g, CHCl3: MeOH = 30:1) gave compound 7a (37.9 mg, 0.0972 mmol, 48%) as a white solid.
 

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