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Chemical Structure| 354813-15-3 Chemical Structure| 354813-15-3

Structure of 354813-15-3

Chemical Structure| 354813-15-3

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Product Details of [ 354813-15-3 ]

CAS No. :354813-15-3
Formula : C12H17ClN2O2
M.W : 256.73
SMILES Code : O=C(O)C1=CC=C(N2CCN(C)CC2)C=C1.[H]Cl

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Application In Synthesis of [ 354813-15-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 354813-15-3 ]

[ 354813-15-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 910543-72-5 ]
  • [ 354813-15-3 ]
  • N-(5-bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-4-(4-methylpiperazin-1-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
35.7% With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 12h;Inert atmosphere; Heating; 4.1.49 N-(5-Bromo-1-methyl-2-oxo-1,2-dihydropyridin-3-yl)-4-(4-methylpiperazin-1-yl)benzamide (12e) A solution of 4-(4-methylpiperazin-1-yl)benzoic acid (100 mg, 0.45 mmol), <strong>[910543-72-5]3-amino-5-bromo-1-methylpyridin-2(1H)-one</strong> (92 mg, 0.45 mmol), DIPEA (118 mg, 0.9 mmol) and HATU (349 mg, 0.9 mmol) in anhydrous DMF (10 mL) was degassed with nitrogen for 12 h at 90 C. After addition of water (10 mL) and extraction with EtOAc (30 mL), the organic phases were washed with saturated brine. The combined organic layer was dried over Na2SO4, and the solvent was removed in vacuo. The crude product was purified on a silica gel column using hexane/EtOAc (1:1, v/v) as eluent to afford compound 12e (65 mg, 35.7%) as a white solid. MS (ESI) m/z 406.1 [M+H]+; 1H NMR (400 MHz, CDCl3): delta 9.12 (s, 1H), 8.67 (d, J = 2.48 Hz, 1H), 7.84 (d, J = 8.92 Hz, 2H), 7.15 (d, J = 2.48 Hz, 1H), 6.93 (d, J = 9.00 Hz, 2H), 3.62 (s, 3H), 3.78 (t, J = 4.84 Hz, 4H), 2.59 (s, 4H), 2.38 (s, 3H).
 

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