Home Cart 0 Sign in  
X

[ CAS No. 35691-20-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 35691-20-4
Chemical Structure| 35691-20-4
Chemical Structure| 35691-20-4
Structure of 35691-20-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

* Shipping: {[proInfo.prShipping]}

Quality Control of [ 35691-20-4 ]

Related Doc. of [ 35691-20-4 ]

Alternatived Products of [ 35691-20-4 ]
Product Citations

Product Details of [ 35691-20-4 ]

CAS No. :35691-20-4 MDL No. :MFCD09475891
Formula : C8H10ClN3 Boiling Point : -
Linear Structure Formula :- InChI Key :OSBZWNGXKCNMHM-UHFFFAOYSA-N
M.W : 183.64 Pubchem ID :10773821
Synonyms :

Safety of [ 35691-20-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 35691-20-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 35691-20-4 ]
  • Downstream synthetic route of [ 35691-20-4 ]

[ 35691-20-4 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 123-75-1 ]
  • [ 3934-20-1 ]
  • [ 35691-20-4 ]
YieldReaction ConditionsOperation in experiment
75% With triethylamine In ethanol at 20℃; for 0.25 h; General procedure: To a solution of absolute ethanol (5 mL) and dichlorodiazine (3.36 mmol) in a 50mL round-bottom flaskwas added triethylamine (5.03 mmol), followed by the amine (5.03 mmol). The mixture was stirred either under reflux of ethanol (for dichloropyridazine and for dichloropyrazine) or at room temperature (for dichloropyrimidines). The reaction was monitored by GC. Once the starting dichlorodiazinewas completely consumed, the mixture was poured into a saturated NH4Cl solution (20 mL), then extracted with CH2Cl2 (320 mL). The combined organic layers were dried over Na2SO4, filtered, and evaporated under vacuum. The crude solid was triturated in petroleum ether, filtered through a Buchner to afford the pure product.
70% at 20℃; for 12 h; General procedure: To a stirred solution of 2,4-dichloropyrimidine in EtOH was added a solution of the corresponding amine (1.2 equiv) in EtOH. After stirring for 12 h at the same temperature, the reaction mixture was concentrated in vacuo. The residue was quenched with H2O and then extracted with EtOAc. The combined organic layers were dried over MgSO4 and then concentrated in vacuo. The residue was purified by flash column chromatography on silica gel.
Reference: [1] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[2] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[3] Bioorganic and Medicinal Chemistry Letters, 2018,
[4] European Journal of Medicinal Chemistry, 1991, vol. 26, # 7, p. 729 - 733
[5] Patent: WO2009/29617, 2009, A1, . Location in patent: Page/Page column 86-87
  • 2
  • [ 123-75-1 ]
  • [ 3934-20-1 ]
  • [ 35691-20-4 ]
  • [ 33852-01-6 ]
Reference: [1] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 1089 - 1104
[2] Journal of Labelled Compounds and Radiopharmaceuticals, 1998, vol. 41, # 7, p. 577 - 584
Recommend Products
Same Skeleton Products
Historical Records

Related Functional Groups of
[ 35691-20-4 ]

Chlorides

Chemical Structure| 5429-00-5

[ 5429-00-5 ]

2-Chloro-4-(piperidin-1-yl)pyrimidine

Similarity: 0.95

Chemical Structure| 66229-56-9

[ 66229-56-9 ]

N-Butyl-2-chloropyrimidin-4-amine

Similarity: 0.91

Chemical Structure| 62968-41-6

[ 62968-41-6 ]

2-Chloro-4-(diethylamino)pyrimidine

Similarity: 0.91

Chemical Structure| 1420874-27-6

[ 1420874-27-6 ]

(1-(2-Chloropyrimidin-4-yl)piperidin-4-yl)methanamine hydrochloride

Similarity: 0.90

Chemical Structure| 138609-96-8

[ 138609-96-8 ]

2-Chloro-N-cyclopropyl-N-methylpyrimidin-4-amine

Similarity: 0.89

Related Parent Nucleus of
[ 35691-20-4 ]

Pyrrolidines

Chemical Structure| 1083089-94-4

[ 1083089-94-4 ]

(R)-1-(2-Chloropyrimidin-4-yl)pyrrolidin-3-ol

Similarity: 0.88

Chemical Structure| 1379439-07-2

[ 1379439-07-2 ]

(S)-1-(2-Chloropyrimidin-4-yl)pyrrolidin-3-ol

Similarity: 0.88

Chemical Structure| 954228-36-5

[ 954228-36-5 ]

1-(2-Chloropyrimidin-4-yl)pyrrolidin-3-ol

Similarity: 0.88

Pyrimidines

Chemical Structure| 5429-00-5

[ 5429-00-5 ]

2-Chloro-4-(piperidin-1-yl)pyrimidine

Similarity: 0.95

Chemical Structure| 66229-56-9

[ 66229-56-9 ]

N-Butyl-2-chloropyrimidin-4-amine

Similarity: 0.91

Chemical Structure| 62968-41-6

[ 62968-41-6 ]

2-Chloro-4-(diethylamino)pyrimidine

Similarity: 0.91

Chemical Structure| 1420874-27-6

[ 1420874-27-6 ]

(1-(2-Chloropyrimidin-4-yl)piperidin-4-yl)methanamine hydrochloride

Similarity: 0.90

Chemical Structure| 138609-96-8

[ 138609-96-8 ]

2-Chloro-N-cyclopropyl-N-methylpyrimidin-4-amine

Similarity: 0.89