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Chemical Structure| 35857-66-0 Chemical Structure| 35857-66-0

Structure of 35857-66-0

Chemical Structure| 35857-66-0

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Product Details of [ 35857-66-0 ]

CAS No. :35857-66-0
Formula : C9H7Cl3O
M.W : 237.51
SMILES Code : O=C(C1=CC=C(Cl)C(Cl)=C1)CCCl
MDL No. :MFCD09878797
InChI Key :ULARDXFALKMJAJ-UHFFFAOYSA-N
Pubchem ID :12371341

Safety of [ 35857-66-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 35857-66-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 35857-66-0 ]

[ 35857-66-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 35857-66-0 ]
  • [ 124-40-3 ]
  • [ 75144-12-6 ]
YieldReaction ConditionsOperation in experiment
81.9% General procedure: A reaction mixture of the halogenated aralkyl-ketone (II) (0.1 mol) and the amine (VIII) (0.5 mol) as a starting material dissolved in anhydrous ethanol (100 mL) is reacted under reflux for 3 h. TLC (dichloromethane: methanol=20:1) indicates a complete consumption of the starting material (II). The solvent is concentrated down till dry. To the residue, dichloromethane (100 mL) and saturated NaCl solution (40 mL) are added, followed by a 20-min stirring. The organic phase is separated and washed with 5 wt % dilute HCl solution (30 mL). After dried over anhydrous MgSO4, the organic phase is filtered and then concentrated to give the crude product which is then dissolved in ethyl acetate (30 mL) and formed a hydrochloride by adding hydrochloric acid alcohol to the mixture. The intermediate (III) is thus obtained with a yield of 70-95% based on the intermediate (II).
 

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Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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