Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 3590-48-5 Chemical Structure| 3590-48-5

Structure of 3590-48-5

Chemical Structure| 3590-48-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Khatua, Kaustav ; Alugubelli, Yugendar R. ; Yang, Kai S. ; Vulupala, Veerabhadra R. ; Blankenship, Lauren R. ; Coleman, Demonta D. , et al.

Abstract: Main protease (MPro) of SARS-CoV-2, the viral pathogen of COVID-19, is a crucial nonstructural protein that plays a vital role in the replication and pathogenesis of the virus. Its protease function relies on three active site pockets to recognize P1, P2, and P4 amino acid residues in a substrate and a catalytic cysteine residue for catalysis. By converting the P1 Cα atom in an MPro substrate to nitrogen, we showed that a large variety of azapeptide inhibitors with covalent warheads targeting the MPro catalytic cysteine could be easily synthesized. Through the characterization of these inhibitors, we identified several highly potent MPro inhibitors. Specifically, one inhibitor, MPI89 that contained an aza-2,2-dichloroacetyl warhead, displayed a 10 nM EC50 value in inhibiting SARS-CoV-2 from infecting ACE2+ A549 cells and a selectivity index of 875. The crystallog. analyses of MPro bound with 6 inhibitors, including MPI89, revealed that inhibitors used their covalent warheads to covalently engage the catalytic cysteine and the aza-amide carbonyl oxygen to bind to the oxyanion hole. MPI89 represents one of the most potent MPro inhibitors developed so far, suggesting that further exploration of the azapeptide platform and the aza-2,2-dichloroacetyl warhead is needed for the development of potent inhibitors for the SARS-CoV-2 MPro as therapeutics for COVID-19.

Alternative Products

Product Details of [ 3590-48-5 ]

CAS No. :3590-48-5
Formula : C5H5ClN2O2
M.W : 160.56
SMILES Code : O=C(N1)NC=C(CCl)C1=O
MDL No. :MFCD00218445
InChI Key :UCDUBKRXOPMNGH-UHFFFAOYSA-N
Pubchem ID :236125

Safety of [ 3590-48-5 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8
UN#:3261
Packing Group:
 

Historical Records

Categories

Related Functional Groups of
[ 3590-48-5 ]

Chlorides

Chemical Structure| 66947-91-9

A488744 [66947-91-9]

5-(Chloromethyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Similarity: 0.89

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Amides

Chemical Structure| 66947-91-9

A488744 [66947-91-9]

5-(Chloromethyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Similarity: 0.89

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Related Parent Nucleus of
[ 3590-48-5 ]

Pyrimidines

Chemical Structure| 66947-91-9

A488744 [66947-91-9]

5-(Chloromethyl)-6-methylpyrimidine-2,4(1H,3H)-dione

Similarity: 0.89

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85

Chemical Structure| 38009-10-8

A381057 [38009-10-8]

1,3-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl chloride

Similarity: 0.85