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[ CAS No. 848133-35-7 ] {[proInfo.proName]}

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Chemical Structure| 848133-35-7
Chemical Structure| 848133-35-7
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Product Details of [ 848133-35-7 ]

CAS No. :848133-35-7 MDL No. :MFCD03695466
Formula : C6H12ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :UUHNQHFOIVLAQX-BJILWQEISA-N
M.W : 165.62 Pubchem ID :45358758
Synonyms :

Safety of [ 848133-35-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 848133-35-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 848133-35-7 ]

[ 848133-35-7 ] Synthesis Path-Downstream   1~8

  • 1
  • (E)-4-(dimethylamino)-2-butenoic acid hydrochloride [ No CAS ]
  • [ 698387-09-6 ]
  • 2
  • [ 848139-78-6 ]
  • (E)-4-(dimethylamino)-2-butenoic acid hydrochloride [ No CAS ]
  • [ 698387-09-6 ]
YieldReaction ConditionsOperation in experiment
52% Preparation of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide free base. A solution of 4-N,N-dimethylaminocrotonic acid hydrochloride (22.3 g, 0.135 mol, 2.0 eq.) in tetrahydrofuran (0.225 L) and a catalytic amount of dimethylformamide (0.5 mL) was cooled to 0-5 C. Oxalyl chloride (11.4 mL, 0.131 mol, 1.95 eq) was added dropwise over 15 min. The mixture was then warmed to 25-30 C. and stirred for 2 h then cooled to 0-5 C. N-Methyl-2-pyrrolidinone (15 ml) was added. A filtered solution of warm (30 C.) 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)]anilino-3-cyano-7-ethoxy-quinoline (30 g, 0.067 mole, 1.0 eq.) in N-methyl-2-pyrrolidinone (0.27 L) was added dropwise over 30 min keeping the temperature 0-10 C. The mixture was stirred for a minimum of 20 h. Upon completion, the reaction was quenched with water (0.36 L), held for 30 min and then warmed to 40-45 C. Aqueous sodium hydroxide (19 g in 0.15 L water) was added over 30 min to bring the pH to 9-10 followed by adding water (0.39 L). The mixture was stirred for 1 hr, then cooled to room temperature. The resulting precipitates were filtered and washed with water (3×60 mL) until the pH of the washes were 7-8. The wet solids were heated to reflux (70-75 C.) in 1.5:1 acetonitrile:tetrahydrofuran (0.33 L) and the solution cooled over 2 h to room temperature. The product was filtered and washed with cold 1.5:1 acetonitrile:tetrahydrofuran (3×0.01 L). The product was dried (60 C., 10 mm Hg, 24 h) to give the titled compound (19.4 g, 52% uncorrected for strength). 1H NMR: delta (DMSO-d6) 9.59 (s, 1H, NH), 9.47 (s, 1H, NH), 8.96 (s, 1H, Ar), 8.60 (dd, 1H, Ar), 8.47 (s, 1H, Ar), 7.87 (dd, 1H, Ar), 7.58 (d, 1H, Ar), 7.39-7.34 (m, 3H, Ar), 7.27-7.20 (m, 2H, Ar), 6.81-6.73 (m, 1H, CH2-CHCH-), 6.59 (d, 1H, CH2-CHCH-), 5.28 (s, 2H, OCH2Pyr), 4.31 (q, 2H, OCH2CH3), 3.09 (d, 2H, N-(CH2), 2.18 (s, 6H, N(CH3)2), 1.47 (t, 3H, OCH2CH3).
  • 3
  • [ CAS Unavailable ]
  • [ 848133-35-7 ]
  • [ 1508250-71-2 ]
YieldReaction ConditionsOperation in experiment
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide hydrochloride With triethylamine In N,N-dimethyl-formamide for 120h; 5 Example 5(R,E)-N-(7-chloro- 1 -(1 -(4-(dimethylamino)but-2-enoyl)azepan-3 -yl)- 1H-benzo[dlimidazol-2-yl)-2-methylisonicotinamide A mixture of (E)-4-(dimethylamino)but-2-enoic acid hydrochloride (58 mg, 0.35 mmol) and 1 -ethyl-3 -(3 -dimethylaminopropyl)carbodiimide hydrochloride (67 mg, 0.35 mmol) in DMF (2 mL) was treated with hydroxybenzotriazole (54 mg, 0.35 mmol) andstirred at room temperature for 1 h. The resulting mixture was added to a solution of 1-27 (100 mg, 0.22 mmol) in DMF (2 mL). Triethylamine (199 mg, 1.97 mmol) was then added and the mixture was stirred for 5 days. Water (2 mL) was added and the mixture was concentrated under reduced pressure. The residue was diluted with iN NaOH (20 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washedwith water (50 mL) and brine (2 x 50 mL), dried over Na2504, and concentrated under reduced pressure. The crude was purified by column chromatography (9:1:0. 175N CH2C12/MeOHJNH3 in CH2C12, 0% to 100%) to afford the title compound (Example 5). 1H NMR (400 MHz, DMSO-d6) 5 8.59 (d, J = 4.8 Hz, 1H), 7.89 (s, 1H), 7.79 (d, J = 4.8 Hz, 1H), 7.60 (d, J= 7.5 Hz, 1H), 7.30-7.22 (m, 2H), 6.71-6.65 (m, 1H), 6.57-6.54 (m,1H), 5.54 (br. s, 1H), 4.54 (br. s, 1H), 4.20 (br s, 1H), 3.95 (br s, 1H), 3.48 (br s, 1H), 2.98(br s, 2H), 2.72 (d, J = 12.0 Hz, 1H), 2.58 (s, 3H), 2.14 (br s, 6H), 2.05 (d, J = 6.7 Hz,3H), 1.88 (br s, 1H), 1.46 (d, J=11.3 Hz, 1H); MS calculated for C26H32C1N602 (M+H)495.22, found 495.10. Melting point (114.6 °C).
  • 4
  • [ 1508259-70-8 ]
  • [ 848133-35-7 ]
  • [ 1508250-71-2 ]
YieldReaction ConditionsOperation in experiment
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide With triethylamine In N,N-dimethyl-formamide for 120h; 1 (R,E-N-(7-chloro- 1 -(1 -(4-(dimethylaminobut-2-enoyflazeran-3-yl- 1 H-benzo [dlimidazol-2-yfl-2 -methylisonicotinamide A mixture of(E)-4-(dimethylamino)but-2-enoic acid hydrochloride (58 mg, 0.35 mmol)and 1 -ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (67 mg, 0.35 mmol) inDMF (2 mL) was treated with hydroxybenzotriazole (54 mg, 0.35 mmol) and stirred at room temperature for 1 h. The resulting mixture was added to a solution of 1-27 (100 mg, 0.22 mmol) in DMF (2 mL). Triethylamine (199 mg, 1.97 mmol) was then added and the mixture was stirred for 5 days. Water (2 mL) was added and the mixture was concentrated underreduced pressure. The residue was diluted with iN NaOH (20 mL) and extracted with EtOAcx 50 mL). The combined organic layers were washed with water (50 mL) and brine (2 x 50 mL), dried over Na2504, and concentrated under reduced pressure. The crude was purified by column chromatography (9:1 :0.175N CH2C12/MeOH/NH3 in CH2C12, 0% to 100%) to afford the title compound. ‘H NMR (400 MHz, DMSO-d6) ö 8.59 (d, J 4.8 Hz, 1H), 7.89 (s, 1H),7.79 (d, J= 4.8 Hz, 1H), 7.60 (d, J= 7.5 Hz, 1H), 7.30-7.22 (m, 2H), 6.7 1-6.65 (m, 1H),6.57-6.54 (m, 1H), 5.54 (br. s, 1H), 4.54 (br. s, 1H), 4.20 (br s, 1H), 3.95 (br s, 1H), 3.48 (br s,1H), 2.98 (br s, 2H), 2.72 (d, J= 12.0 Hz, 1H), 2.58 (s, 3H), 2.14 (br s, 6H), 2.05 (d, J= 6.7Hz, 3H), 1.88 (br s, 1H), 1.46 (d, J=1 1.3 Hz, 1H); MS calculated for C26H32C1N602 (M+H)495.22, found 495.10. Melting point (114.6 °C).
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide With triethylamine In N,N-dimethyl-formamide for 120h; 1 (R,E)-N-(7-chloro- 1 -(1 -(4-(dimethylamino)but-2-enoyl)azepan-3 -yl)- 1 H-benzo [dl imidazol-2-yl)-2-methylisonicotinamide A mixture of (E)-4-(dimethylamino)but-2-enoic acid hydrochloride (58 mg, 0.35 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (67 mg, 0.35 mmol) inDIVIF (2 mL) was treated with hydroxybenzotriazole (54 mg, 0.35 mmol) and stirred at room temperature for 1 h. The resulting mixture was added to a solution of 1-27 (100 mg, 0.22 mmol) in DIVIF (2 mL). Triethylamine (199 mg, 1.97 mmol) was then added and the mixture was stirred for 5 days. Water (2 mL) was added and the mixture was concentrated under reduced pressure. The residue was diluted with iN NaOH (20 mL) and extracted with EtOAc(3 x 50 mL). The combined organic layers were washed with water (50 mL) and brine (2 x 50 mL), dried over Na2504, and concentrated under reduced pressure. The crude was purified by column chromatography (9:1:0.1 75N CH2C12/MeOH/NH3 in CH2C12, 0% to 100%) to afford the title compound. ‘H NIVIR (400 IVIHz, DMSO-d6) ö 8.59 (d, J= 4.8 Hz, 1H), 7.89 (s, 1H), 7.79 (d, J 4.8 Hz, 1H), 7.60 (d, J 7.5 Hz, 1H), 7.30-7.22 (m, 2H), 6.71-6.65 (m, 1H),6.57-6.54 (m, 1H), 5.54 (br. s, 1H), 4.54 (br. s, 1H), 4.20 (br s, 1H), 3.95 (br s, 1H), 3.48 (br s, 1H), 2.98 (br s, 2H), 2.72 (d, J= 12.0 Hz, 1H), 2.58 (s, 3H), 2.14 (br s, 6H), 2.05 (d, J=6.7 Hz, 3H), 1.88 (br s, 1H), 1.46 (d, J=11.3 Hz, 1H); MS calculated for C26H32C1N602 (M+H) 495.22, found 495.10. Melting point (114.6 °C).
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide With triethylamine In N,N-dimethyl-formamide for 120h; 1 (R,E)-N-(7-chloro- 1 -(1 -(4-(dimethylamino)but-2-enoyl)azepan-3-yl)- 1 H-benzo[dlimidazol-2-yl)-2-methylisonicotinamide A mixture of(E)-4-(dimethylamino)but-2-enoic acid hydrochloride (58 mg, 0.35 mmol) and 1 -ethyl-3 -(3 -dimethylaminopropyl)carbodiimide hydrochloride (67 mg, 0.35 mmol) in DMF (2 mL) was treated with hydroxybenzotriazole (54 mg, 0.35 mmol) and stirred at room temperature for 1 h. The resulting mixture was added to a solution of 1-27 (100 mg, 0.22mmol) in DMF (2 mL). Triethylamine (199 mg, 1.97 mmol) was then added and the mixture was stirred for 5 days. Water (2 mL) was added and the mixture was concentrated under reduced pressure. The residue was diluted with iN NaOH (20 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water (50 mL) and brine (2 x 50 mL), dried over Na2SO4, and concentrated under reduced pressure. The crude was purified bycolumn chromatography (9:1:0.175N CH2C12/MeOH/NH3 in CH2C12, 0% to 100%) to afford the title compound. ‘H NMR (400 MHz, DMSO-d6) ö 8.59 (d, J 4.8 Hz, 1H), 7.89 (s, 1H), 7.79 (d, J 4.8 Hz, 1H), 7.60 (d, J 7.5 Hz, 1H), 7.30-7.22 (m, 2H), 6.7 1-6.65 (m, 1H),6.57-6.54 (m, 1H), 5.54 (br. s, 1H), 4.54 (br. s, 1H), 4.20 (br s, 1H), 3.95 (br s, 1H), 3.48 (br s, 1H), 2.98 (br s, 2H), 2.72 (d, J= 12.0 Hz, 1H), 2.58 (s, 3H), 2.14 (br s, 6H), 2.05 (d, J6.7 Hz, 3H), 1.88 (br s, 1H), 1.46 (d, J=1 1.3 Hz, 1H); MS calculated for C26H32C1N602 (M+H) 495.22, found 495.10. Melting point (114.6 °C).
  • 5
  • [ 848133-35-7 ]
  • [ 1702864-43-4 ]
  • [ 1472797-69-5 ]
YieldReaction ConditionsOperation in experiment
12.5 g Stage #1: (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride; (S)-N-(5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)-2-(methylamino)propanamide dihydrochloride With 4-methyl-morpholine In N,N-dimethyl-formamide at 20℃; for 0.166667h; Stage #2: With isobutyl chloroformate In N,N-dimethyl-formamide at 20℃; for 1.5h; 7 10203] To a solution of (S)-N-(5-(2-((4-cyanophenyl) amino)-4-(propylamino)pyrimidin-5-yl-4-pentyn-1 -yl-2-(methylamino)propanamide (A6) dihydrochloride (19.0 g) and 4-dimethylaminocrotonic acid hydrochloride (22.3 g) in N,N-dimethylformamide (550 mE), N-methylmorpholine (42.4 mE) was added at room temperature, and the mixture was stirred at the same temperature for 10 minutes. Then, isobutyl chioroformate (15.2 mE) was added dropwise to the mixture under ice cooling, and the mixture was stirred at the same temperature for 1 hour and 30 minutes. Saturated aqueous sodium hydrogencarbonate (200 mE) was added to the reaction mixture, and the solvent was evaporated under reduced pressure. Water and ethyl acetate were added to the obtained residue. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. Acetonitrile was added to the obtained residue, and the solid was collected by filtration and purified by basic silica gel colunm chromatography (eluent, 95% ethyl acetate/5% methanol) to obtain (S,E)-N-(1 -(5-(2-((4-cy- anophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1 -yl)amino)-1 -oxopropan-2-yl)-4-(dimethylamino)-N- methylbut-2-enamide (compound A, 12.5 g).10204] MS mlz (M+H): 531.510205] MS mlz (M-H): 529.510206] ‘H-NMR (CDC13) ö: 8.05 (1H, s), 7.97 (1H, s), 7.79 (2H, d, J=8.6 Hz), 7.56 (2H, d, J=9.2 Hz), 6.94 (1H, dt, J=15.2, 5.3 Hz), 6.71 (1H, t, J=5.6 Hz), 6.44-6.42 (2H, m), 5.20 (1H, q, J=7.3 Hz), 3.49-3.45 (4H, m), 3.11 (2H, d, J=5.3 Hz), 3.01 (3H, s), 2.45 (2H, t, AJ=6.6 Hz), 2.27 (6H, s), 1.77-1.66 (4H, m), 1.36 (3H, d, J=7.3 Hz), 1.00 (3H, t, J=7.3 Hz)
  • 6
  • [ 1508258-36-3 ]
  • [ 848133-35-7 ]
  • [ 1508250-71-2 ]
YieldReaction ConditionsOperation in experiment
56% Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide hydrochloride With triethylamine In N,N-dimethyl-formamide for 24h;
Stage #1: (E)-4-(dimethylamino)-2-butenoic acid hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: (R)-N-(1-(azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide hydrochloride With triethylamine In N,N-dimethyl-formamide for 120h; 5.1 A mixture of (E)-4-(dimethylamino)but-2-enoic acid hydrochloride (58 mg, 0.35 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (67 mg, 0.35 mmol) in DMF (2mL) was treated with hydroxybenzotriazole (54 mg, 0.35 mmol) and stirred at roomtemperature forl h. The resulting mixture was added to a solution of 1-27 (100 mg, 0.22mmol) in DMF (2 mL). Triethylamine (199 mg, 1.97 mmol) was then added and the mixture was stirred for 5 days. Water (2 mL) was added and the mixture was concentrated under reduced pressure. The residue was diluted with 1 N NaOH (20 mL) and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water (50 mL) and brine (2 x 50 mL), dried over Na2SO4, and concentrated under reduced pressure. The crude was purifiedby column chromatography (9:1:0.175N CH2CI2/MeOH/NH3 in CH2CI2, 0% to 100%) to affordthe title compound. 1H NMR (400 MHz, DMSO-d6) O 8.59 (d, J = 4.8 Hz, 1 H), 7.89 (5, 1 H),7.79 (d, J= 4.8 Hz, 1H), 7.60 (d, J= 7.5 Hz, 1H), 7.30-7.22 (m, 2H), 6.71-6.65 (m, 1H), 6.57-6.54 (m, 1H), 5.54 (br. s, 1H), 4.54 (br. s, 1H), 4.20 (brs, 1H), 3.95 (brs, 1H), 3.48 (brs, 1H),2.98 (brs, 2H), 2.72 (d, J= 12.0 Hz, 1H), 2.58 (5, 3H), 2.14 (brs, 6H), 2.05 (d, J= 6.7 Hz,3H), 1.88 (brs, 1H), 1.46 (d, J=11.3 Hz, 1H); MS calculated f0rC26H32CIN6O2 (M+H) 495.22, found 495.10. Melting point (114.6°C).
  • 7
  • [ 848139-78-6 ]
  • (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride [ No CAS ]
  • [ 698387-09-6 ]
YieldReaction ConditionsOperation in experiment
95% (E)-4-(dimethylamino)but-2-enoic acid hydrochloride (8.92 g; 53.82 mmoL) was charged to glass reactor (250 mL) inertized with nitrogen. Dichloromethane (85 mL) and dimethylformamide (DMF; 318 tL; 4.12 mmoL) were added. Suspension was cooled to 0- 5 C and oxalyl chloride (4.0 mL; 45.76 mL) was added dropwise during 5 - 10 mm. Dropping funnel was washed with dichloromethane (5 mL). Reaction mixture was stirred for 8- 9 h in nitrogen atmosphere and monitored by HPLC. After finish of reaction, solution of 6- amino-4-((3 -chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3 -carbonitrile (12.0 g; 26.91 mmoL) in N-methyl-2-pyrrolidone (NMP, 120 mL) was added dropwise during 15 - 30 mm while maintaining the temperature below 10 C. Reaction mixture was heated to 20 - 25 C and stirred for 2 - 16 h (reaction was monitored by HPLC until NRT-3 was below0.2 Area %). After completion of reaction, water (120 mL) was added and layers separated.Into water layer NMP (48 mL) and THF (96 mL) were added and pH was adjusted to 10.0 -10.5 by addition of 2 M NaOH while maintaining the temperature at 20 -25 C. Mixture wasstirred at 20 - 25 C for 2 h, cooled to 0 - 5 C duringi h, stirred for 2 h and filtered. Crystalswere washed with THF/water mixture (1:2; 2 x 15 mL) and dried under vacuum at 50 C for16 h at 10 mbar to obtain Neratinib base form Bi (Y: 95%).
  • 8
  • [ 848133-35-7 ]
  • [ 1474036-76-4 ]
  • [ 1472797-69-5 ]
YieldReaction ConditionsOperation in experiment
43.1 g With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In N,N-dimethyl acetamide at 10 - 15℃; for 5.75h; 11 Example 11 25.3 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 18.7 g of ethyl(hydroxyimino)cyanoacetate, and 40.0 g of 4-methylmorpholine were sequentially added to 200 mL of N,N-dimethylacetamide, and then the mixture was cooled to 10° C. 40.0 g of (S)-N-(5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)-2-(meth ylamino)propanamide dihydrate and 21.8 g of 4-dimethylaminocrotonic acid hydrochloride were added to the mixture, and the mixture was stirred for 5 hours and 45 minutes at a temperature of 10° C. to 15° C. 400 mL of 4-methyl-2-pentanone was added to the reaction mixture, and then 400 mL of a 15% aqueous sodium chloride solution was added thereto. The reaction mixture was left to stand overnight at room temperature, 48 mL of a 25% aqueous sodium hydroxide solution was then added thereto, and the mixture was stirred for 20 minutes at a temperature of 30° C. to 40° C. The organic layer was fractionated and washed with a 10% aqueous sodium chloride solution. 400 mL of water and 17.2 mL of acetic acid were sequentially added to the obtained organic layer. The water layer was fractionated, 400 mL of methanol was added thereto, and the mixture was cooled to 30° C. Then, 35.1 mL of a 25% aqueous sodium hydroxide solution was added thereto, and the mixture was stirred for 2 hours at a temperature of 20° C. to 30° C. The reaction mixture was cooled to 10° C. and stirred for 2 hours at a temperature of 0° C. to 10° C. The solid content was collected by filtration, thereby obtaining 43.1 g of (S,E)-N-(1-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)-4-pentyn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methyl-2-butenamide as a pale yellow solid.
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