362703-34-2|1-tert-Butyl 4-methyl 4-cyanopiperidine-1,4-dicarboxylate| Ambeed

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Quality Control of [ 362703-34-2 ] Purity: 97% SDS Specification

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Product Details of [ 362703-34-2 ]

CAS No. :	362703-34-2
Formula :	C₁₃H₂₀N₂O₄
M.W :	268.31
SMILES Code :	O=C(N1CCC(C(OC)=O)(C#N)CC1)OC(C)(C)C
MDL No. :	MFCD18711601
InChI Key :	BNHQNHASKIVGOW-UHFFFAOYSA-N
Pubchem ID :	60082456

Safety of [ 362703-34-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Application In Synthesis of [ 362703-34-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 362703-34-2 ]

[ 362703-34-2 ] Synthesis Path-Downstream 1~35

1
[ 362703-34-2 ]
[ 362703-35-3 ]

Yield	Reaction Conditions	Operation in experiment
81%	With hydrogen;platinum(IV) oxide; In ethyl acetate; under 2585.81 Torr; for 2.0h;	A solution of the piperidine (1.07 g, 3.98 mmol) from reaction (24b) and a catalytic amount of platinum oxide in acetic acid (20 mL) was pressurized with 50 psi of hydrogen for 2 hr. The mixture was filtered through Celite and concentrated. The residue was dissolved in ethyl acetate (20 mL) and washed with saturated sodium bicarbonate solution (2×20mL) and brine (2×20 mL). The organic layer was dried and concentrated to give the desired amine (880 mg, 81%). MS found: (M+H)+=273.
60%	With hydrogen; nickel; triethylamine; In methanol; under 2068.65 Torr;	To a solution of intermediate 3 (10 g, 37.3 mmol) and triethylamine (1 mL) in MeOH (200 mL) was added Raney-Ni carefully. The resulting mixture was hydrogenated (40 psi H2) overnight. The reaction was filtered through celite, concentrated under vacuum, and purified by preparative HPLC to give intermediate 4 (6 g, 60% yield) as a colorless oil.

References: [1]Patent: US2004/72802,2004,A1 .Location in patent: Page/Page column 47.
[2]Bioorganic and Medicinal Chemistry Letters,2011,vol. 21,p. 5910 - 5915.
[3]Patent: WO2015/150337,2015,A1 .Location in patent: Page/Page column 34; 35.
[4]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

2
[ 105-34-0 ]
[ 159635-50-4 ]
[ 362703-34-2 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

3
[ 362703-34-2 ]
[ 362703-37-5 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

4
[ 362703-34-2 ]
N-hydroxy-4-[[[4-[(2-methyl-4-quinolinyl)methoxy]benzoyl]amino]methyl]-4-piperidinecarboxamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

5
[ 362703-34-2 ]
1-methanesulfonyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-methyl}-piperidine-4-carboxylic acid methyl ester [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

6
[ 362703-34-2 ]
[ 362703-41-1 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

7
[ 362703-34-2 ]
[ 362703-39-7 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

8
[ 362703-34-2 ]
N-hydroxy-4-[({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)methyl]-1-propyl-4-piperidinecarboxamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

9
[ 362703-34-2 ]
N-hydroxy-4-[({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)methyl]-1-(methylsulfonyl)-4-piperidinecarboxamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

10
[ 362703-34-2 ]
[ 362703-36-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

11
[ 362703-34-2 ]
1-[2,2-dimethylpropionyl]-N-hydroxy-4-[[[4-[(2-methyl-4-quinolinyl)methoxy]benzoyl]amino]methyl]-4-piperidinecarboxamide [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

12
[ 362703-34-2 ]
[ 362697-41-4 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2006,vol. 16,p. 2699 - 2704.

13
[ 362703-33-1 ]
[ 24424-99-5 ]
[ 362703-34-2 ]