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CAS No. : | 36293-05-7 | MDL No. : | MFCD09903682 |
Formula : | C10H11ClO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XSKYEGXKYATCRE-UHFFFAOYSA-N |
M.W : | 182.65 | Pubchem ID : | 12369086 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501 | UN#: | 3265 |
Hazard Statements: | H314 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With thionyl chloride; benzene | ||
With thionyl chloride | ||
With phosphorus trichloride |
With thionyl chloride for 1h; | ||
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 4h; | ||
With phosphorus pentachloride | ||
With thionyl chloride for 3h; Heating; | ||
With oxalyl dichloride In dichloromethane for 2h; | ||
With thionyl chloride In toluene for 1h; Heating / reflux; | ||
With oxalyl dichloride | ||
With oxalyl dichloride; N,N-dimethyl-formamide In hexane | ||
With oxalyl dichloride | ||
With oxalyl dichloride In dichloromethane at 0℃; for 3h; | 208.A 5-chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-dimethylamino-1,1-dimethylethyl)benzylamino]benzamide Step A. To a solution of 2-methyl-2-phenylpropionic acid (5.0 g, 30.49 mmol) inCH2C12 at 0 C was added oxalyl chloride (4.0 ml, 45.7 mmol). The mixture was stirred at 0 C for 3 hr. Solvent was evaporated and the residue was dried. The above residue was dissolved inCH2Cl2, and dimethylamine was purged for 20 min. or until saturated. The mixture was stirred rt for lhr. The reaction mixture was washed with water, 1N HC1, sat'dNaHC03, and brine. Chromatography purification gave N, N-dimethyl-2-phenyl-isobutyramide as white solid. MS found:(M+1) +=192. 2. | |
With oxalyl dichloride In dichloromethane for 2h; | B6; B9 2,2-dimethylphenyl acetic acid (CAS 826-55-1) (2.5 g, 15 mmol) was dissolved in dry CH2C12 (50 mL), oxalyl chloride (1.5 mL, 0.017 mol) was added and one drop of DMF. After stirring for two hours, the solution was evaporated till dryness, redissolved in 50 mL of CH2C12, and added to a solution of 2-amino adamantane (CAS 13074-39-0) (2.5 g, 15 mmol) and triethylamine (3. 0 g, 30 mmol) in CH2C12 (50 mL). The mixture was stirred overnight, extracted with 15% citric acid, SAT. NAHCO3 and brine, dried over MGS04, and evaporated in vacuo. The residue was chromatographed over silicagel (eluens 3-5% MEOH in CH2C12), yielding the title compounds. 1.8 g of trans-, NMR : (CDC13) 8 1.2-1. 85 (m, CH), 1.59 (s, 6H, (CH3) 2), 1.95-2. 00 (m, 2H, CH), 3.91 (dt, 1H, CH), 5.32 (d, 1H, NH), 7.25-7. 47 (m, 5H, Ar-H). And 1.8 g of cis isomer. NMR: (CDC13) 5 1.2-1. 7 (m, CH), 1.56 (s, 6H, (CH3) 2), 2.05-2. 10 (m, 2H, CH), 3.83 (dt, 1H, CH), 5.32 (d, 1H, NH), 7.25-7. 50 (m, 5H, Ar-H) | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; Inert atmosphere; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; Inert atmosphere; | ||
With thionyl chloride for 3h; Inert atmosphere; Reflux; | ||
With thionyl chloride for 1h; Reflux; | 4 A solution of α,α dimethyl phenylacetic acid (2 g, 12.18 mmol) in thionyl chloride (20 ml) is heated to reflux for 1 hour after which time all of the starting acid has been consumed. The reaction mixture is concentrated in vacuo and the resulting acid chloride is used directly for the synthesis of [(tert-butoxy)carbonyl]amino 2-methyl-2-phenylpropanoate, which is prepared from the described acid chloride and N-tert-butoxycarbonyl hydroxylamine according to Scheme 1. (2.76 g, 81%), 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 7.64 (1H, s), 7.29 (4H, dt, 15.6, 7.8 Hz), 7.12-7.23 (1H, m), 1.60 (6H, s), 1.38 (9H, s). | |
With thionyl chloride at 85℃; for 3h; Inert atmosphere; | ||
With thionyl chloride for 5h; Reflux; | ||
With oxalyl dichloride In dichloromethane | 10 Compound 1-236[00516] To a solution of 2-methyl-2-phenylpropanoic acid (11 equiv) in dichloromethane was added oxalyl chloride (33 equiv) and catalytic N,N-dimethylformamide. Once gas evolution ceased, this solvent was removed in vacuo. The crude acid chloride was redissolved in dichloromethane and added portion- wise to a suspension of Compound 1-107 (1 equiv) in dichloromethane/pyridine (2:1) until the absence of starting material was observed by LC/MS. Following an aqueous ammonium chloride and dichloromethane workup, purification via silica gel chromatography (0-10% methanol in dichloromethane) did not provide sufficiently pure material. Repurification using ethyl acetate in hexanes as an eluent provided the desired compound as a white solid (57%). 1H NMR (400 MHz, CD3OD) δ 8.74 (m, IH), 8.03 (s, IH), 7.48-7.46 (m, 2H), 7.41-7.36 (m, 3H), 7.30-7.21 (m, 2H), 7.09-7.04 (m, IH), 7.01 (t, IH), 6.85-6.79 (m, 2H), 5.93 (s, 2H), 1.67 (s, 6H). | |
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 3h; Inert atmosphere; | ||
With thionyl chloride In tetrahydrofuran at 25℃; for 1h; Inert atmosphere; | ||
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 25 - 45℃; for 12h; | 2 Example-2: Preparation of 2-methyl-2-phenylpropanoyl chloride (FormuIa-4) Example-2: Preparation of 2-methyl-2-phenylpropanoyl chloride (FormuIa-4) Thionyl chloride (217.2 gm) was slowly added to a mixture of 2-methyl-2- phenylpropanoic acid compound of formula-3 (100 gm), dichloromethane (500 ml) and dimethylformamide (8.9 gm) at 25-30°C. Heated the reaction mixture to 40-45°C and stirred for 12 hrs at the same temperature. Distilled off the solvent completely form the reaction mixture under reduced pressure and the obtained compound is utilized in the next step. | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 17h; | ||
With thionyl chloride for 3h; Reflux; | ||
With oxalyl dichloride | ||
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 17h; Inert atmosphere; Schlenk technique; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere; | ||
With oxalyl dichloride | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 17h; Inert atmosphere; Schlenk technique; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; | 207E 207E N-methoxy-N-methyl-2-phenyl-isobutyramide To a solution of 2-methyl-2-phenyl-propionic acid (24.06g, 150 mmoles) in CH2Cl2 (150 mL) is added oxalyl chloride(21 g, 0.165 mmoles) and 5 drops of DMF. The reactionmixture is stirred overnight at room temperatures (reactionvessel connected to a bubbler to remove gases formed duringthe reaction). The solvent and volatiles are removed underreduced pressure to afford the acylchloride.A part of the residual oil (16 g, 87.6 mmoles) is dissolvedin CH2Cl2 (20 ml) and N,O-dimethylhydroxylamine.hydrochloride(9.0 g, 90 mmoles) and NEt3 (22.7 g, 219 mmoles)are added. The reaction mixture is stirred overnight at roomtemperature. CH2Cl2 is added to dilute the mixture and theorganic phase is washed with water, O.lN HCl, brine, driedover MgS04 , filtered and the solvent is removed underreduced pressure to give N-methoxy-N-methyl-2-phenylisobutyramide. | |
With thionyl chloride In toluene for 2h; Reflux; | 2.6 Example 6 500 mL reaction flask, 63 g of 2-methyl-2-phenylpropionic acid (II), 250 mL of toluene and 150 g of thionyl chloride were added, Heating reflux reaction 2h, HPLC monitoring reaction is complete, Vacuum dry solvent and excess of thionyl chloride, Plus 100mL toluene dissolved, Cooling to 0 ~ 5 , A solution of cesium carbonate (375 g) / water (180 g) was slowly added dropwise, Add insulation for 10min, A solution of N, O-dimethylhydroxylamine hydrochloride (40 g) in water (80 g) was added dropwise, Plus, Natural temperature to room temperature reaction 2h, HPLC monitoring reaction is complete, Separate the organic layer, The aqueous layer was extracted with dichloromethane 200 mL * 2, Combined organic layer, Were washed with 1N hydrochloric acid, saturated sodium bicarbonate solution and saturated brine, respectively, Dried over anhydrous sodium sulfate, Filtered to give an oil, Vacuum distillation, The bp: 112 ~ 115 ° C / 3 mmHg fraction was collected, To give 75 g of N-methoxy-N, 2-dimethyl-2-phenylpropionamide (III) Purity 98%, yield 94.3%. among them, 2-methyl-2-phenylpropionic acid (II), N, O-dimethylhydroxylamine hydrochloride, the molar ratio of base is 1: 1.1: 3. | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; | ||
With N,N-dimethyl-formamide In chloroform at 80℃; for 3h; | ||
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 17h; Schlenk technique; Inert atmosphere; | ||
With thionyl chloride for 5h; Heating / reflux; | 24 Synthesis 24 3-(-1 -Phenyl-1 -methylethyl)-8-carbamoylimidazotetrazin-4-one (BB-006); Thionyl chloride (1.33 ml_, 18.27 mmol) was added drop wise to α,α-dimethylphenylacetic acid (Alfa Lancaster) (2.0 g, 12.18 mmol) and the mixture heated at reflux. After 5 hours, the thionyl chloride was removed by distillation at 78°C, then by co-evaporation with toluene at 1100C. The residue (α,α-dimethylphenylacetyl chloride) was used in the next step without further purification. | |
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 25 - 30℃; for 2h; Inert atmosphere; Large scale; | 13.1 Step-1 A mixture of 2-methyl-2-phenylpropanoic acid (50 Kg) and dichloromethane (250 Lt) was stirred for 15 min at 25-30°C. N,N-dimethylformamide (2.5 Lt) was added to the obtained solution at 25-30°C. Thionyl chloride (54.5 Kg) was slowly added to the reaction mixture at 25-30°C under nitrogen atmosphere and stirred the reaction mixture for 2 hrs at the same temperature. Distilled off the solvent completely from the reaction mixture and co-distilled with dichloromethane. | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 3h; Inert atmosphere; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 17h; | General procedure: Oxalyl chloride (1.75 mL, 20 mmol) was added dropwise to a stirred solution of thecarboxylic acid in CH2Cl2 (20 mL) and DMF (0.1 mL) at 0 C. The mixture wasstirred for 1 h at 0 C and another 16 h at room temperature, and evaporated in vacuoto give the crude acid chloride IV, which was used directly for the next step withoutfurther purification. | |
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 23℃; for 2h; | ||
With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 17h; | ||
With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 2h; Inert atmosphere; | ||
With thionyl chloride at 65℃; for 1h; | 63.A Step A: Preparation of Diethyl 2-(2-methyl-2- phenylpropanoyl)malonate; [0766] EtOH (31.9 mL) and CCl4 (0.441 mL) were added to magnesium(2.22 g, 91.3 mmol) and diethyl malonate (13.8 mL, 91.3 mmol) at ambient temperature. THF (91.3 mL) was added slowly to control the reaction and maintain the temperature under reflux. The reaction mixture was then heated to 700C for 2 hours and cooled to room temperature. Meanwhile, the acid chloride of alpha^lpha-dimethylphenylacetic acid (10.0 g, 60.9 mmol) was formed by addition of thionyl chloride (3OmL) followed by heating to 65°C for 1 hour. The mixture was cooled, concentrated and redissolved in ether (2OmL). The resulting acid chloride solution was added dropwise via addition funnel to the magnesium enolate as prepared above. The reaction mixture was stirred for 1 hour and then quenched with IN HCl, diluted with 200 mL of diethyl ether, added to a separatory funnel, partitioned with water, washed 2 times with 50 mL of water, separated, dried over Na2SC^, and concentrated in vacuo to give the title compound (22.1 1 g). MS (m/z) = 307 (M+H)+. | |
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 20℃; | 3.1.1. 2-(4-(2-Chloroacetyl)phenyl)-N-Methoxy-N,2-Dimethylpropanamide (19) To a stirred solution of 2-methoxy-2-phenylpropionic acid (1.0 Kg, 6.1 mol) in dichloromethane (5 L) and dimethyl formamide (50 mL) was slowly added thionylchloride (1.08 Kg, 9.1 mol) at ambient temperature. The mixture was stirred at that temperature for 10-12h and after completion of reaction,the reaction mass was distilled and added with dichloromethane (5 L) to make 2-methoxy-2-phenylpropionyl chloridesolution (X). In another RBF N-methyl-O-methyl hydroxylamine hydrochloride (0.66 Kg, 7.3 mol) was added tothe stirred solution of sodium carbonate (0.77 Kg, 7.3 mol) and water (5 L) at 0°C. At the same temperature acid chloride solution (X) was added to reaction mixture and stirred for 2-3 h. After completion of reaction, organic layer was separated from reaction mass and distilled to get N-methoxy-N,2-dimethylpropanamide as residue. This residue was dissolved in dichloromethane (2.5 L) and added to the stirred solution of aluminium trichloride (1.62 Kg, 12.1 mol), dichloromethane (3.7 L) and chloroacetyl chloride (0.82 Kg, 7.3 mol) at 0°C. The mixture was stirred at ambient temperature for 4-5 h. After completion of reaction, chilled water (5 L) was added to mass and extracted the organic mass withdichloromethane (5 L). The organic layer was washed with5% brine solution (5 L) and solvent was evaporated under reduced pressure. The obtained residue was dissolved in ethyl acetate (100 mL). Cyclohexane was added to the resulting mass and stirred at 0°C for 1 hr. The precipitated solid was filtered and washed with cyclohexane (1 L) and dried inthe oven to afford title compound 19 as a white solid (1.06 Kg, 61%). | |
With phosphorus pentachloride In chloroform-d1 at 20℃; for 2h; | ||
With phosphorus pentachloride In dichloromethane at 20℃; for 2h; Inert atmosphere; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere; | ||
With thionyl chloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 2h; | ||
With chlorinating agent In dichloromethane at 0℃; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; | ||
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 3h; | ||
With thionyl chloride at 85℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In diethyl ether |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; triethylamine In ethanol; dichloromethane; water | 19.h Step h Step h and step 1: 2-(4-Cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid, 2-ethylhexyl ester Mix methylene chloride (50 mL), 2-ethylhexyl alcohol (130 g, 1 mol) and triethylamine (50 g, 0.5 mol). Add, by dropwise addition, ethyl dimethylphenylacetyl chloride (91 g, 0.5 mol). Heat the reaction mixture to 68C for 1 hour, add methylene chloride (100 mL) and stir overnight. Remove the solids by filtration, wash with methylene chloride (50 mL), combine with the liquid organics, wash with aqueous 5% HCl, (50 mL), water (50 mL) and dry over MgSO4. Evaporate the solvent in vacuo and purify by distillation (119 C at 1 mmHg) (105 g, 76%). Place aluminum chloride (29.3 g) and methylene chloride (30 mL) in a 250 mL round bottom flask with an overhead stirrer, temperature control, condenser, additonal funnel and nitrogen atmosphere. Add, by dropwise addition, chlorobutyryl chloride (16.9 g), keeping the temperature below 10C. After addition is complete, warm the reaction mixture to 36C and hold for 24 hours. Quench the reaction mixture into ice/water (200 g) and extract with methylene chloride (50 mL). Wash the organics with water (50 mL) and dry (MgSO4). Evaporate the solvent in vacuo to give an oil (30 g). Place the oil in a 250 mL flask equipped with an overhead stirrer, gas inlet, condenser and thermometer. Add 2B ethanol (150 mL) followed by anhydrous HCl (5 g). Heat the reaction mixture to 76C for 2.5 hours then add additional HCl (5 g). Heat the reaction mixture at 76C for 22 hours, evaporate the solvent in vacuo to give an oil. | |
With hydrogenchloride; triethylamine In ethanol; dichloromethane; water | 2-(4-Cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid, 2-ethylhexyl ester 2-(4-Cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid, 2-ethylhexyl ester Mix methylene chloride (50 mL), 2-ethylhexyl alcohol (130 g, 1 mol) and triethylamine (50 g, 0.5 mol). Add, by dropwise addition, ethyl dimethylphenylacetyl chloride (91 g, 0.5 mol). Heat the reaction mixture to 68 C. for 1 hour, add methylene chloride (100 mL) and stir overnight. Remove the solids by filtration, wash with methylene chloride (50 mL), combine with the liquid organics, wash with aqueous 5% HCl, (50 mL), water (50 mL) and dry over MgSO4. Evaporate the solvent in vacuo and purify by distillation (119 C. at 1 mmHg) (105 g, 76%). Place aluminum chloride (29.3 g) and methylene chloride (30 mL) in a 250 mL round bottom flask with an overhead stirrer, temperature control, condenser, additonal funnel and nitrogen atmosphere. Add, by dropwise addition, chlorobutyryl chloride (16.9 g), keeping the temperature below 10 C. After addition is complete, warm the reaction mixture to 36 C. and hold for 24 hours. Quench the reaction mixture into ice/water (200 g) and extract with methylene chloride (50 mL). Wash the organics with water (50 mL) and dry (MgSO4). Evaporate the solvent in vacuo to give an oil (30 g). Place the oil in a 250 mL flask equipped with an overhead stirrer, gas inlet, condenser and thermometer. Add 2B ethanol (150 mL) followed by anhydrous HCl (5 g). Heat the reaction mixture to 76 C. for 2.5 hours then add additional HCl (5 g). Heat the reaction mixture at 76 C. for 22 hours, evaporate the solvent in vacuo to give an oil. | |
Stage #1: 2-Ethylhexyl alcohol; 2-methyl-2-phenylpropanoyl chloride With triethylamine In dichloromethane at 68℃; Stage #2: 2-chlorobutyryl chloride In dichloromethane at 10 - 36℃; | 19.hl EXAMPLE 19 Step h and Step 1 2-(4-Cyclopropanecarbonyl-phenyl)-2-methyl-propionic acid, 2-ethylhexyl Ester Mix methylene chloride (50 mL), 2-ethylhexyl alcohol (130 g, 1 mol) and triethylamine (50 g, 0.5 mol). Add, by dropwise addition, ethyl dimethylphenylacetyl chloride (91 g, 0.5 mol). Heat the reaction mixture to 68 C. for 1 hour, add methylene chloride (100 mL) and stir overnight. Remove the solids by filtration, wash with methylene chloride (50 mL), combine with the liquid organics, wash with aqueous 5% HCl, (50 mL), water (50 mL) and dry over MgSO4. Evaporate the solvent in vacuo and purify by distillation (119 C. at 1 mmHg) (105 g, 76%). Place aluminum chloride (29.3 g) and methylene chloride (30 mL) in a 250 mL round bottom flask with an overhead stirrer, temperature control, condenser, additonal funnel and nitrogen atmosphere. Add, by dropwise addition, chlorobutyryl chloride (16.9 g), keeping the temperature below 10 C. After addition is complete, warm the reaction mixture to 36 C. and hold for 24 hours. Quench the reaction mixture into ice/water (200 g) and extract with methylene chloride (50 mL). Wash the organics with water (50 mL) and dry (MgSO4). Evaporate the solvent in vacuo to give an oil (30 g). Place the oil in a 250 mL flask equipped with an overhead stirrer, gas inlet, condenser and thermometer. Add 2B ethanol (150 mL) followed by anhydrous HCl (5 g). Heat the reaction mixture to 76 C. for 2.5 hours then add additional HCl (5 g). Heat the reaction mixture at 76 C. for 22 hours, evaporate the solvent in vacuo to give an oil. Dissolve the oil in 2B ethanol (100 mL), treat with solid KOH (10 g) and heat at reflux for 2 hours. |
Tags: 36293-05-7 synthesis path| 36293-05-7 SDS| 36293-05-7 COA| 36293-05-7 purity| 36293-05-7 application| 36293-05-7 NMR| 36293-05-7 COA| 36293-05-7 structure
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P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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