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Chemistry
Heterocyclic Building Blocks
Imidazoles
5-Chloro-1-methyl-1H-imidazole-2-carbaldehyde
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Imidazoles
Chlorides Aldehydes

[ CAS No. 37050-18-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
Chemical Structure| 37050-18-3
Chemical Structure| 37050-18-3
Structure of 37050-18-3 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 37050-18-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification
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Product Details of [ 37050-18-3 ]

CAS No. :37050-18-3 MDL No. :MFCD22052499
Formula : C5H5ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 144.56 Pubchem ID :-
Synonyms :

Safety of [ 37050-18-3 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 37050-18-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37050-18-3 ]

[ 37050-18-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 80-65-9 ]
  • [ 37050-18-3 ]
  • [ 36948-15-9 ]
Reference： [1]Bollettino Chimico Farmaceutico,1971,vol. 110,p. 645 - 652
  • 2
  • [ 431-67-4 ]
  • [ 37050-18-3 ]
  • [ 111851-99-1 ]
YieldReaction ConditionsOperation in experiment
With sodium acetate; In methanol; water; EXAMPLE 27 4'-(Trifluoromethyl)-5-chloro-1-methyl-2,2'-bi-1H-imidazole A mixture of 7.6 g (0.028 moles) <strong>[431-67-4]1,1-dibromo-3,3,3-trifluoroacetone</strong>, 2.5 g (0.3 moles) sodium acetate and 15 ml water was heated on a steam bath for one-half hour. This cooled solution was added to 3.4 g (0.0235 moles) 5-chloro-1-methylimidazole-2-carboxaldehyde in 100 ml methanol. Finally, 25 ml concentrated ammonium hydroxide was added slowly. After stirring for 5 hours the reaction was concentrated and then extracted with ethyl acetate (2 x 75 ml). After drying (anhydrous sodium sulfate) and concentration, 5.3 g gummy tan solid was obtained. Recrystallization (toluene) gave 2.16 g (36.7%) light tan crystals, mp 217-219C. Nmr (dimethyl sulfoxide-d6 delta 3.15-3.80 (br s, 1H), 4.05 (s, 3H), 7.19 (s, 1H), 7.86 (s, H); ms (70 EV, electron impact) m/e 250 (molecular ion), 231 (M+F), 215 (M+Cl). Anal. Calcd. for C863lN4 C, 38.34; H, 2.41; N, 22.36. Found: C, 38.43; H, 2.44; N, 22.17.
Reference： [1]Journal of Medicinal Chemistry,1990,vol. 33,p. 317 - 327
[2]Patent: EP229922,1992,B1
  • 3
  • [ 1450-76-6 ]
  • [ 37050-18-3 ]
  • (E)-3-(5-Chloro-1-methyl-1H-imidazol-2-yl)-1-(2-hydroxy-5-nitro-phenyl)-propenone [ No CAS ]
YieldReaction ConditionsOperation in experiment
93% With sodium hydroxide In ethanol Ambient temperature;
Reference： [1]Khilya, V.P.; Grishko, L.G.; Golubushina, G.M.; Arkhipova, N.N.; Turov, A.V. [Chemistry of Heterocyclic Compounds, 1994, vol. 30, # 8, p. 916 - 922][Khimiya Geterotsiklicheskikh Soedinenii, 1993, # 8, p. 1063 - 1070]
  • 4
  • [ 334893-99-1 ]
  • [ 37050-18-3 ]
YieldReaction ConditionsOperation in experiment
98% With Dess-Martin periodane; In dichloromethane; at 0 - 20℃; for 4.0h; A Dess-Martin reagent (1.04 g, 2.46 mmol) was added to a solution of <strong>[334893-99-1](5-chloro-1-methyl-1H-imidazol-2-yl)methanol</strong> (0.300 g, 2.05 mmol) in dichloromethane (20.0 mL) at 0 C. The reaction liquid was stirred at room temperature for 4 hours. The reaction liquid was filtered through Celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, n-hexane/ethyl acetate) to obtain 5-chloro-1-methyl-1H-imidazole-2-carbaldehyde (0.289 g, 2.00 mmol, 98%) as a white solid. (0157) 1H-NMR (400 MHz, CDCl3) delta: 3.97 (3H, s), 7.24 (1H, s), 9.70 (1H, s).
Reference： [1]Patent: US2018/72701,2018,A1 .Location in patent: Paragraph 0155-0158
  • 5
  • [ 53473-85-1 ]
  • [ 37050-18-3 ]
  • N-((5-chloro-1-methyl-1H-imidazol-2-yl)methyl)benzo[d]-isothiazol-5-amine [ No CAS ]
Reference： [1]Journal of Medicinal Chemistry,2021,vol. 64,p. 5931 - 5955

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