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Chemical Structure| 37143-54-7 Chemical Structure| 37143-54-7

Structure of 37143-54-7

Chemical Structure| 37143-54-7

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Product Details of [ 37143-54-7 ]

CAS No. :37143-54-7
Formula : C4H11NO
M.W : 89.14
SMILES Code : CC(N)COC
MDL No. :MFCD00008084

Safety of [ 37143-54-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H302-H314-H412
Precautionary Statements:P210-P273-P280-P305+P351+P338-P310
Class:3(8)
UN#:2733
Packing Group:

Application In Synthesis of [ 37143-54-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37143-54-7 ]

[ 37143-54-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 42237-85-4 ]
  • [ 37143-54-7 ]
  • [ 1562518-73-3 ]
YieldReaction ConditionsOperation in experiment
1.07 g With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; at 20℃;Cooling with ice; Intermediate D5: (S)-3-Amino-5- pan-2-yl)benzamide. A stirred mixture of <strong>[42237-85-4]3-amino-5-bromobenzoic acid</strong> (900 mg, 4.04 mmol), (S)-1- methoxypropan-2-amine (860 mu, 8.14 mmol) and triethylamine (1.7 mL, 12.20 mmol) in DCM (15 mL) was cooled in an ice bath. 50 wt% T3P in EtOAc (3.6 mL, 6.05 mmol) was added dropwise, the ice bath was removed and the reaction mixture allowed to warm to rt. DMF (2 mL) was added to aid solubility and the reaction stirred at rt overnight. The reaction mixture was partitioned between sat. aq. NaHC03 (50 mL) and DCM (50 mL). The aqueous phase was back extracted with fresh DCM (50 mL). The combined organic extracts were washed with water (100 mL), brine (100 mL), dried (MgS04), filtered and concentrated in vacuo to afford an orange oil. The crude product was purified by chromatography on silica gel (40 g column, 0-5% MeOH in DCM) to afford Intermediate D5 (1.07 g) as an orange oil. H NMR (DMSO-d6) 400 MHz, delta: 8.11 (d, 1 H), 7.08 (t, 1 H), 6.99-6.98 (m, 1 H), 6.84 (t, 1 H), 5.56 (s, 2H), 4.18-4.08 (m, 1 H), 3.39-3.35 (m, 1 H), 3.26-3.22 (m, 1 H), 3.25 (s, 3H), 1.09 (d, 3H). LCMS m/z 287/289 (M+H)+ (ES+)
  • 2
  • [ 2105-96-6 ]
  • [ 37143-54-7 ]
  • (S)-4-((1-methoxypropan-2-yl)amino)-3-nitrophenol [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% Intermediate 250: (S)-4-((1-methoxypropan-2-yl)amino)-3-nitrophenol A mixture of <strong>[2105-96-6]4-<strong>[2105-96-6]fluoro-3-nitrophenol</strong></strong> (1.0 g, 6.37 mmol), (S)-1-methoxypropan-2-amine (1.13 g, 1.35 mL, 12.73 mmol) and diisopropylethylamine (1.65 g, 2.22 mL, 12.73 mmol) in dioxan (10 mL) was refluxed for 2 hours. The solvent was evaporated, the residue was dissolved in N-methyl-2- pyrrolidone (10 mL). The mixture was heated in a microwave at 180C for 4 hours. The cooled reaction mixture was partitioned between ethyl acetate (50 mL) and water (25 mL). The organic phase was separated, washed with water (2x25 mL), dried and evaporated. The residue was chromatographed [10-40percent ethyl acetate/cyclohexane] to give the title compound (1.31 g, 5.79 mmol, 91 percent yield), as an orange solid. LCMS (System A): tRET = 0.89 min; MH+ 227.
  • 3
  • [ 6311-37-1 ]
  • [ 37143-54-7 ]
  • (S)-4-amino-3-bromo-N-(1-methoxypropan-2-yl)benzamide [ No CAS ]
 

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