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Chemical Structure| 372-41-8 Chemical Structure| 372-41-8

Structure of 372-41-8

Chemical Structure| 372-41-8

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Product Details of [ 372-41-8 ]

CAS No. :372-41-8
Formula : C6H7FN2
M.W : 126.13
SMILES Code : FC1=CC(N)=CC(N)=C1
MDL No. :MFCD12763398

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Application In Synthesis of [ 372-41-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 372-41-8 ]

[ 372-41-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6914-79-0 ]
  • [ 372-41-8 ]
  • [ 947689-80-7 ]
YieldReaction ConditionsOperation in experiment
58% Example 8A; N-(3-Amino-5-fluorophenyl)-1-cyanocyclopropanecarboxamide; 1,1-Carbonyldiimidazole (3.29 g) is added to 1-cyanocyclopropanecarboxylic acid (2.05 g) in THF and the resulting solution is stirred at room temperature for 45 min. 5-Fluoro-1,3-aminobenzene (3.00 g) is added and the mixture is stirred for a further 2.5 h. Subsequently, the reaction solution is concentrated, the residue is taken up in DCM (150 ml) and washed with water. The aqueous phase is extracted twice with DCM. The organic extracts are pooled, dried over sodium sulfate and concentrated. The residue is chromatographed on silica gel (eluent DCM to DCM-methanol 50:1). After concentrating the relevant fraction 2.35 g (58percent of theory) of product are isolated.LC-MS (Method 1): Rt=1.31 minMS (ESI): m/z=220 [M+H]+
 

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