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[ CAS No. 372118-01-9 ]

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Chemical Structure| 372118-01-9
Chemical Structure| 372118-01-9
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CAS No. :372118-01-9 MDL No. :MFCD09953612
Formula : C6H4Cl2N2O2 Boiling Point : 345.2°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :207.01 g/mol Pubchem ID :17848322
Synonyms :

Safety of [ 372118-01-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 372118-01-9 ]

  • Upstream synthesis route of [ 372118-01-9 ]
  • Downstream synthetic route of [ 372118-01-9 ]

[ 372118-01-9 ] Synthesis Path-Upstream   1~3

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YieldReaction ConditionsOperation in experiment
72% at 95℃; for 5 h; Step 3
4,6-Dichloro-pyridazine-3-carboxylic acid methyl ester
A mixture of 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester (10.5 g, 61.7 mmol) and POCl3 (70 mL) was heated to 95° C. for 5 h.
The excess POCl3 was removed under reduced pressure, then the crude residue was added to ice-water (250 mL) and extracted with ethyl acetate (3*100 mL).
The combined extracts were dried then concentrated to give a crude residue which was purified by chromatography (silica, 100-200 mesh, 30percent ethyl acetate in hexane) to give 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (9.2 g, 72percent) as an off white solid. LC-MS: 207.0 [M+H]+.
Reference: [1] Patent: US2013/178478, 2013, A1, . Location in patent: Paragraph 0301;0302
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1, . Location in patent: Page 18
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Reference: [1] Patent: US2013/178478, 2013, A1,
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1,
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Reference: [1] Patent: US2013/178478, 2013, A1,
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2683 - 2691
[3] Patent: US2004/77653, 2004, A1,
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