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[ CAS No. 372120-54-2 ] {[proInfo.proName]}

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Chemical Structure| 372120-54-2
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Product Details of [ 372120-54-2 ]

CAS No. :372120-54-2 MDL No. :MFCD13185397
Formula : C8H6BrF3O Boiling Point : -
Linear Structure Formula :- InChI Key :JYYKPISNWWYHOY-UHFFFAOYSA-N
M.W : 255.03 Pubchem ID :11391180
Synonyms :

Safety of [ 372120-54-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 372120-54-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 372120-54-2 ]

[ 372120-54-2 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 372120-51-9 ]
  • [ 372120-54-2 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; sodium nitrite;copper(I) bromide; In water; hydrogen bromide; EXAMPLE 63A [3-bromo-4-(trifluoromethyl)phenyl]methanol The product from Example 62B (0.76 g, 4 mmol) in water (8 mL) at 0 C. was treated with concentrated H2SO4 (3 mL) and then treated dropwise with an aqueous solution of sodium nitrite (0.41 g, 6 mmol) keeping the temperature below 10 C. After stirring for 1 hour, this solution was added to a solution of copper(I) bromide (0.85 g, 5 mmol) in 48% hydrobromic acid (50 mL). The reaction mixture was heated at 60 C. for 3 hours, cooled to ambient temperature and partitioned between water and ethyl acetate. The organic layer was washed with aqueous sodium carbonate, dried over MgSO4 and concentrated to provide the title compound contaminated with approximately 30% of 2-bromo-4-(bromomethyl)-1-(trifluoromethyl)benzene.
  • 2
  • [ 372120-54-2 ]
  • [ 372120-55-3 ]
YieldReaction ConditionsOperation in experiment
With manganese dioxide; In chloroform; EXAMPLE 63B 3-bromo-4-(trifluoromethyl)benzaldehyde The product from Example 63A in chloroform (100 mL) was treated with manganese dioxide (1.1 g, 12.6 mmol) and stirred overnight. The mixture was filtered and the filtrate was concentrated. The residue was chromatographed on silica gel eluding with 15% ethyl acetate/hexanes to rovide the title compound (0.28 g). 1H NMR (CDCl3) delta 7.9 (m, 2H), 8.2 (s, 1H), 10.02 (s, 1H).
  • 3
  • [ 557-21-1 ]
  • [ 372120-54-2 ]
  • 5-(hydroxymethyl)-2-(trifluoromethyl)benzonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
47% With bis(tri-t-butylphosphine)palladium(0); In N,N-dimethyl-formamide; at 130.0℃; for 2.0h;Microwave irradiation; 3-Bromo-4-trifluoromethylphenyl methanol (0.300g, 1.17mmol), zinc cyanide (0.276 g, 2.35mmol), palladium bis tributylphosphine (60.2mg, 0.118mmol) were mixed in N, N- dimethylformamide (2.5mL), and at 130 in the use of microwave stirred for 2 hours. The obtained reaction mixture was added to the water, and extracted with ethyl acetate. Utilizing organic layer was dried over anhydrous sodium sulfate, filtered, then concentrated. Utilizing silica column chromatography (n-hexane / ethyl acetate) The residue obtained was purified, thereby obtaining the title compound (0.112g, 47%).
  • 4
  • [ 372120-54-2 ]
  • 5-formyl-2-(trifluoromethyl)benzonitrile [ No CAS ]
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