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[ CAS No. 374538-03-1 ]

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Chemical Structure| 374538-03-1
Chemical Structure| 374538-03-1
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Product Details of [ 374538-03-1 ]

CAS No. :374538-03-1 MDL No. :MFCD02179452
Formula : C8H9BO4 Boiling Point : 359°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :179.97 g/mol Pubchem ID :2773496
Synonyms :

Safety of [ 374538-03-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 374538-03-1 ]

  • Upstream synthesis route of [ 374538-03-1 ]
  • Downstream synthetic route of [ 374538-03-1 ]

[ 374538-03-1 ] Synthesis Path-Upstream   1~5

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  • [ 67-56-1 ]
  • [ 149105-19-1 ]
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YieldReaction ConditionsOperation in experiment
96.7% at 40 - 55℃; Autoclave; Industrial scale In a 20 L autoclave, 7.5 g of anhydrous methanol and 1.66 Kg (10 mol) of o-carboxyphenylboronic acid were added and the reaction was stirredThe kettle is warmed to 40 ° C,Temperaturewise 40 to 55 ° C To the reaction kettle, thionyl chloride (1.31 Kg, 11 mol) was added dropwise,After the drop, the temperature was raised to reflux reaction for 2-3 hours.After confirming that the reaction was complete (TLC: n-heptane: ethyl acetate = 2: 1)The reaction solution was cooled,The solvent was distilled off under reduced pressure, cooled to -10 ° C to 10 ° C, stirred for 1 hour, filtered at 80 ° C under reduced pressure until HNMR confirmed no impurities (HNMR: DMS 0-c / 6 at 3.21 ppm Peak) to stop drying. After stirring at room temperature, the mixture was filtered and dried at room temperature to give 1.74 Kg of white solid, 96.7percent yield, 19.8percent water content and 140.5percent for Karl Fischer.
Reference: [1] Patent: CN106188117, 2016, A, . Location in patent: Paragraph 0014
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Reference: [1] Organic Letters, 2006, vol. 8, # 2, p. 305 - 307
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Reference: [1] Journal of the American Chemical Society, 2012, vol. 134, # 28, p. 11667 - 11673
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Reference: [1] Journal of the American Chemical Society, 2012, vol. 134, # 28, p. 11667 - 11673
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  • [ 653589-95-8 ]
Reference: [1] Synthesis (Germany), 2012, vol. 44, # 14, p. 2173 - 2180
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