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Chemical Structure| 37454-51-6 Chemical Structure| 37454-51-6

Structure of 37454-51-6

Chemical Structure| 37454-51-6

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Product Details of [ 37454-51-6 ]

CAS No. :37454-51-6
Formula : C6H9N3O2
M.W : 155.15
SMILES Code : O=C(N1)NC=C(N(C)C)C1=O
MDL No. :MFCD09702477
InChI Key :UUJYJQMSFALWBX-UHFFFAOYSA-N
Pubchem ID :255552

Safety of [ 37454-51-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 37454-51-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 37454-51-6 ]

[ 37454-51-6 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 51-20-7 ]
  • [ 124-40-3 ]
  • [ 37454-51-6 ]
  • 3
  • [ 37454-51-6 ]
  • [ 76513-69-4 ]
  • [ 592527-84-9 ]
  • 5
  • [ 37454-51-6 ]
  • 5-dimethylamino-3-(3-{4-[4-fluoro-2-(2,2,2-trifluoro-ethoxy)-phenyl]-piperazin-1-yl}-propyl)-1<i>H</i>-pyrimidine-2,4-dione [ No CAS ]
  • 7
  • [ 51-20-7 ]
  • [ 124-40-3 ]
  • [ 37454-51-6 ]
YieldReaction ConditionsOperation in experiment
69% In tetrahydrofuran; at 100.0℃; for 16.0h;Autoclave; A solution of 5-bromopimidine-2,4(1H,3H)-dione 1 (1.5 g, 7.85 mmol) in Me2NH (15 mL, 2 M in THF) was stirred in autoclave at 100 C for 16 h. Theresulting mixture was cooled down to room temperature and concentrated in vacuum, the residue was washed with water and dried to give 5- (dimethylamino)pyrimidine-2,4(1H,3H)-dione 2 (840 mg, 69%) as a yellow solid. LRMS (M + H) m/z: calcd 156.07; found 156. ‘H NMR (300 MHz, DMSO) 5: 11.00 (s, 1H), 10.41 (s, 1H), 6.65 (s, 1H), 2.52 (s, 6H).
  • 8
  • [ 37454-51-6 ]
  • 1-(4-(benzylamino)-5-(dimethylamino)pyrimidin-2-yl)-2-methyl-1H-indole-4-carboxamide [ No CAS ]
  • 9
  • [ 37454-51-6 ]
  • [ 5298-50-0 ]
YieldReaction ConditionsOperation in experiment
68% With trichlorophosphate; for 2.0h;Reflux; A solution of the aforementioned intermediate 2 (400 mg, 2.58 mmol) in POd3 (10 mL) was heated to reflux and stirred for 2 h. The mixture was cooled to room temperature and poured slowly into ice-water (100 mL). The aqueous phase was extracted with DCM (50 mL x 3). The organic layers were combined and dried over Na2SO4. The Na2SO4 was removed by filtration, and the volatileswere removed under reduced pressure, and the residue was purified by flashchromatography using a mixture of DCM and THF to give 2,4-dichloro-N,N-dimethylpyrimidin-5-amine 3 (340 mg, 68%) as a yellow oil. LRMS (M + H)m/z: calcd 192.00; found 192.
  • 10
  • [ 37454-51-6 ]
  • N<SUP>4</SUP>-benzyl-2-chloro-N<SUP>5</SUP>,N<SUP>5</SUP>-dimethylpyrimidine-4,5-diamine [ No CAS ]
  • 11
  • [ 37454-51-6 ]
  • 1-(4-(benzylamino)-5-(dimethylamino)pyrimidin-2-yl)-2-methyl-1H-indole-4-carbonitrile [ No CAS ]
 

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